WormBase Tree Display for Gene: WBGene00003133
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WBGene00003133 | SMap | S_parent | Sequence | CHROMOSOME_II | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||||
Name | CGC_name | apc-1 | Person_evidence | WBPerson29989 | |||||
Sequence_name | W10C6.1 | ||||||||
Molecular_name | W10C6.1 | ||||||||
W10C6.1.1 | |||||||||
CE54528 | |||||||||
Other_name | pod-3 | ||||||||
evl-22 | |||||||||
mat-2 | Person_evidence | WBPerson205 | |||||||
apc-17 | Person_evidence | WBPerson1816 | |||||||
WBPerson205 | |||||||||
CELE_W10C6.1 | Accession_evidence | NDB | BX284602 | ||||||
Public_name | apc-1 | ||||||||
DB_info | Database (11) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
2 | 03 Jan 2022 22:40:49 | WBPerson1983 | Event | Acquires_merge | WBGene00007501 | ||||
Name_change | CGC_name | apc-1 | |||||||
Other_name | mat-2 | ||||||||
Acquires_merge | WBGene00007501 | ||||||||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | apc | ||||||||
Allele (171) | |||||||||
Legacy_information | [Shakes DC] Mutation is defective in metaphase to anaphase transition. | ||||||||
[C.elegansII] ar104 : everted vulva, sterile, no L4 vulval invagination; no uterine cavity; no sperm or oocytes. NA1. [Seydoux et al., 1993] | |||||||||
Strain (11) | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (18) | |||||||||
Contained_in_operon | CEOP2516 | ||||||||
Ortholog (47) | |||||||||
Structured_description | Concise_description | mat-2 encodes a subunit of the anaphase-promoting complex or cyclosome (APCC) which is a multi-subunit E3 ubiquitin ligase that targets proteins for degradation during the metaphase-to-anaphase transition of the cell cycle; mat-2 is required for chromosome segregation during meiosis I and is involved in polarity specification of the anterior/posterior axis in the developing embryo. | Paper_evidence (4) | ||||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
Automated_description | Predicted to enable molecular adaptor activity. Involved in several processes, including establishment of meiotic spindle localization; metaphase/anaphase transition of cell cycle; and polarity specification of anterior/posterior axis. Part of anaphase-promoting complex. Human ortholog(s) of this gene implicated in Rothmund-Thomson syndrome. Is an ortholog of human ANAPC1 (anaphase promoting complex subunit 1). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:2732 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:19988) | ||||
Molecular_info | Corresponding_CDS | W10C6.1 | |||||||
Corresponding_CDS_history | W10C6.1:wp197 | ||||||||
W10C6.1:wp282 | |||||||||
Corresponding_transcript | W10C6.1.1 | ||||||||
Other_sequence | Oden_isotig19802 | ||||||||
CBC06189_1 | |||||||||
EX553911.1 | |||||||||
MP00954 | |||||||||
Acan_isotig09044 | |||||||||
Tcol_isotig14030 | |||||||||
JI236511.1 | |||||||||
ACC09101_1 | |||||||||
EX553361.1 | |||||||||
Dviv_isotig23131 | |||||||||
Associated_feature | WBsf658222 | ||||||||
WBsf989629 | |||||||||
WBsf989630 | |||||||||
WBsf222095 | |||||||||
WBsf222096 | |||||||||
WBsf222097 | |||||||||
Experimental_info | RNAi_result (13) | ||||||||
Expr_pattern | Expr1013593 | ||||||||
Expr1026786 | |||||||||
Expr1031478 | |||||||||
Expr1033226 | |||||||||
Expr1144328 | |||||||||
Expr1158612 | |||||||||
Expr2009353 | |||||||||
Expr2013391 | |||||||||
Expr2027589 | |||||||||
Expr2031623 | |||||||||
Microarray_results (37) | |||||||||
Expression_cluster (169) | |||||||||
Interaction (120) | |||||||||
Map_info | Map | II | Position | 3.31638 | Error | 0.004741 | |||
Positive | Positive_clone | W10C6 | Inferred_automatically | From CDS info | |||||
From sequence, transcript, pseudogene data | |||||||||
Mapping_data | Multi_point | 3923 | |||||||
3466 | |||||||||
4551 | |||||||||
4599 | |||||||||
Pos_neg_data | 10567 | ||||||||
10568 | |||||||||
10569 | |||||||||
10570 | |||||||||
Reference (38) | |||||||||
Method | Gene |