WormBase Tree Display for Gene: WBGene00003112
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| WBGene00003112 | SMap | S_parent | Sequence | F35G12 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | mab-21 | Person_evidence | WBPerson261 | |||||
| Sequence_name | F35G12.6 | ||||||||
| Molecular_name | F35G12.6 | ||||||||
| F35G12.6.1 | |||||||||
| CE32651 | |||||||||
| Other_name | CELE_F35G12.6 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | mab-21 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mab | ||||||||
| Allele (30) | |||||||||
| Legacy_information | [Chow KL] Transformation of thick ray 6 to a thin ray, which is anteriorly displaced and fuses with ray 4 (>95%). A tenth ray derived from hypodermal cell T.apapa is found in about 50% of the sides scored in all three alleles. mab-21(bx53)/yDf10 is embryonic lethal. Both males and hermaphrodites have slightly shorter body length (~85% of wild type) | ||||||||
| [C.elegansII] bx53 : transformation of thick ray 6 to a thin ray, which is anteriorly displaced and fuses with ray 4 (>95%). Tenth ray derived from T.apapa, between rays 5 and 7, is found in ~50% of sides scored. Both males and hermaphrodites have slightly shorter body length (~85% of wild type); reduced brood size; males backward Unc, reduced mating efficiency. Mosaic focus cell autonomous for R6, non-autonomous for T.apapa. Probable hypomorph, bx53/Df is embryonic lethal. OA2: bx41, sy155 (similar). Cloned: encodes predicted 386 aa novel protein. [Baird et al. 1991; Chow et al. 1995; KC; EM; PS] | |||||||||
| Complementation_data | [Chow KL] complements emb-1(hc57), emb-2(hc58), emb-5(hc61), emb-7(hc66), emb-8(hc69), emb-13(g6), emb-32(g58) | ||||||||
| Strain | WBStrain00002152 | ||||||||
| WBStrain00030819 | |||||||||
| WBStrain00007160 | |||||||||
| WBStrain00007166 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00066952 | ||||||||
| 00066953 | |||||||||
| 00066954 | |||||||||
| 00066955 | |||||||||
| Ortholog (38) | |||||||||
| Structured_description | Concise_description | mab-21 encodes a novel protein that is a member of a highly conserved family of proteins with Drosophila and vertebrate orthologs; MAB-21 is cell-autonomously required for specifying the identity of sensory ray 6 in the male tail, and also for backward locomotion, normal body morphology, fecundity, and embryonic morphogenesis; MAB-21 expression begins in embryonic hypodermal cells and continues in larval and adult animals in hypodermis, anterior and ventral cord neurons, some body wall muscles, and ray cells. | Paper_evidence | WBPaper00002335 | |||||
| WBPaper00004801 | |||||||||
| WBPaper00013240 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Involved in cell fate commitment; embryo development; and nematode male tail mating organ morphogenesis. Expressed in several structures, including PVC; VA2; hyp7 syncytium; ray 6; and sensory neurons. Human ortholog(s) of this gene implicated in coloboma and syndromic microphthalmia 14. Is an ortholog of human MAB21L1 (mab-21 like 1) and MAB21L2 (mab-21 like 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0111802 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6758) | ||||
| DOID:12270 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6758) | ||||||
| Molecular_info | Corresponding_CDS | F35G12.6 | |||||||
| Corresponding_transcript | F35G12.6.1 | ||||||||
| Other_sequence (37) | |||||||||
| Associated_feature | WBsf645104 | ||||||||
| WBsf645105 | |||||||||
| WBsf224765 | |||||||||
| Experimental_info | RNAi_result (26) | ||||||||
| Expr_pattern (12) | |||||||||
| Drives_construct | WBCnstr00002911 | ||||||||
| WBCnstr00004455 | |||||||||
| WBCnstr00010357 | |||||||||
| WBCnstr00012531 | |||||||||
| WBCnstr00021618 | |||||||||
| WBCnstr00036224 | |||||||||
| Construct_product | WBCnstr00010357 | ||||||||
| WBCnstr00021618 | |||||||||
| WBCnstr00036224 | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (150) | |||||||||
| Interaction (17) | |||||||||
| Map_info | Map | III | Position | -3.02765 | Error | 0.006765 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | C56A8 | |||||||
| F35G12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Negative | Negative_clone | F10F2 | |||||||
| W03D1 | |||||||||
| Mapping_data | 2_point | 4694 | |||||||
| 4696 | |||||||||
| 6035 | |||||||||
| 6036 | |||||||||
| 6037 | |||||||||
| 6038 | |||||||||
| Multi_point (15) | |||||||||
| Pos_neg_data | 4695 | ||||||||
| 6012 | |||||||||
| 6013 | |||||||||
| 6014 | |||||||||
| 6015 | |||||||||
| 6016 | |||||||||
| 6017 | |||||||||
| 6018 | |||||||||
| Reference (55) | |||||||||
| Method | Gene |
