WormBase Tree Display for Gene: WBGene00003068
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| WBGene00003068 | Evidence | Person_evidence | WBPerson1068 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | T27C10 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | lrk-1 | Person_evidence | WBPerson1315 | |||||
| Sequence_name | T27C10.6 | ||||||||
| Molecular_name | T27C10.6 | ||||||||
| T27C10.6.1 | |||||||||
| CE41939 | |||||||||
| Other_name | LRRK2 | Paper_evidence | WBPaper00045582 | ||||||
| CELE_T27C10.6 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | lrk-1 | ||||||||
| DB_info | Database (14) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lrk | ||||||||
| Allele (160) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (28) | |||||||||
| Ortholog (36) | |||||||||
| Paralog (12) | |||||||||
| Structured_description | Concise_description | lrk-1 encodes the sole C. elegans homolog of the leucine-rich repeat kinases, LRRK1 and the familial Parkinsonism gene PARK8/LRRK2; in C. elegans, lrk-1 is required for polarized localization of synaptic vesicle proteins to presynaptic regions; LRK-1 functions antagonistically to PINK-1 to regulate oxidative and endoplasmic reticulum stress response as well as neurite outgrowth; LRK-1 is widely expressed and localizes to the Golgi apparatus. | Paper_evidence | WBPaper00029175 | |||||
| WBPaper00032949 | |||||||||
| WBPaper00034758 | |||||||||
| WBPaper00036154 | |||||||||
| WBPaper00040114 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 14 Sep 2011 00:00:00 | ||||||||
| Automated_description | Predicted to enable metal ion binding activity; protein kinase activity; and purine ribonucleoside triphosphate binding activity. Involved in several processes, including axon extension involved in axon guidance; cellular localization; and negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. Located in Golgi apparatus and neuronal cell body. Expressed in hermaphrodite distal tip cell; neurons; pharynx; and vulva. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in osteosclerotic metaphyseal dysplasia. Is an ortholog of human LRRK1 (leucine rich repeat kinase 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:14330 | Homo sapiens | Paper_evidence | WBPaper00035592 | ||||
| WBPaper00034758 | |||||||||
| Accession_evidence | OMIM | 607060 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 19 Jan 2018 00:00:00 | ||||||||
| Potential_model | DOID:0081111 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:18608) | |||||
| Disease_relevance | Mutations in human PARK8/LRRK2 (a GTPase regulated kinase) are the most common cause of inherited Parkinson''s disease (PD); C. elegans is used as a model system to study the genetic interactions and molecular functions of PARK protein orthologs; overexpression of either wild-type or mutant (G2019S) LRRK2 enhanced dopaminergic neuron degeneration, while knockdown of the elegans lrk-1 increased toxicity in the nematode to rotenone, a broad spectrum pesticide that interferes with the mitochondrial electron-transport chain; lrk-1/LRRK2 may act together with sek-1/MKK6 and pmk-1/p38 and antagonistic to pink-1/PINK1, another PD-related gene, the loss-of-function of which results in dopaminergic neurons, to modulate the cellular stress response. | Homo sapiens | Paper_evidence | WBPaper00035592 | |||||
| WBPaper00035922 | |||||||||
| WBPaper00032949 | |||||||||
| Accession_evidence | OMIM | 607060 | |||||||
| 609007 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 08 Jan 2014 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000208 | ||||||||
| Models_disease_asserted | WBDOannot00000473 | ||||||||
| Molecular_info | Corresponding_CDS | T27C10.6 | |||||||
| Corresponding_CDS_history | T27C10.6:wp94 | ||||||||
| T27C10.6:wp173 | |||||||||
| T27C10.6:wp185 | |||||||||
| Corresponding_transcript | T27C10.6.1 | ||||||||
| Other_sequence (12) | |||||||||
| Associated_feature | WBsf664892 | ||||||||
| WBsf717574 | |||||||||
| WBsf985118 | |||||||||
| WBsf985119 | |||||||||
| WBsf985120 | |||||||||
| WBsf985121 | |||||||||
| WBsf220297 | |||||||||
| WBsf220298 | |||||||||
| WBsf220299 | |||||||||
| Experimental_info | RNAi_result (14) | ||||||||
| Expr_pattern | Expr4597 | ||||||||
| Expr8648 | |||||||||
| Expr12733 | |||||||||
| Expr1026978 | |||||||||
| Expr1031445 | |||||||||
| Expr1157834 | |||||||||
| Expr2013267 | |||||||||
| Expr2031498 | |||||||||
| Drives_construct | WBCnstr00005648 | ||||||||
| WBCnstr00012104 | |||||||||
| WBCnstr00013419 | |||||||||
| WBCnstr00036251 | |||||||||
| Construct_product | WBCnstr00005648 | ||||||||
| WBCnstr00012104 | |||||||||
| WBCnstr00013419 | |||||||||
| WBCnstr00022702 | |||||||||
| WBCnstr00036251 | |||||||||
| Antibody | WBAntibody00002686 | ||||||||
| Microarray_results (24) | |||||||||
| Expression_cluster (96) | |||||||||
| Interaction (40) | |||||||||
| Map_info | Map | I | Position | 5.69269 | |||||
| Positive | Positive_clone | T27C10 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4480 | |||||||
| Pseudo_map_position | |||||||||
| Reference (54) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| [140923 pad] Modified Map position as it was a reverse physical that could not be fixed by automated methods. | |||||||||
| Method | Gene |
