WormBase Tree Display for Gene: WBGene00003052
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| WBGene00003052 | SMap | S_parent | Sequence | DY3 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | lmn-1 | |||||||
| Sequence_name | DY3.2 | ||||||||
| Molecular_name | DY3.2 | ||||||||
| DY3.2.1 | |||||||||
| CE15746 | |||||||||
| Other_name | Lam1 | Accession_evidence | EMBL | X74027 | |||||
| CELE_DY3.2 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | lmn-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lmn | ||||||||
| Allele (48) | |||||||||
| Strain | WBStrain00026339 | ||||||||
| WBStrain00026341 | |||||||||
| WBStrain00026343 | |||||||||
| WBStrain00040720 | |||||||||
| WBStrain00002790 | |||||||||
| WBStrain00026345 | |||||||||
| WBStrain00034808 | |||||||||
| Component_of_genotype | WBGenotype00000131 | ||||||||
| WBGenotype00000150 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (36) | |||||||||
| Ortholog (49) | |||||||||
| Paralog (12) | |||||||||
| Structured_description | Concise_description | lmn-1 encodes the sole C. elegans nuclear lamin; lmn-1 is an essential gene that is required for a number of nuclear processes, including chromatin organization, cell cycle progression, chromosome segregation, and nuclear pore complex spacing; LMN-1 is also required for nuclear envelope localization of EMR-1/Emerin during early development; LMN-1 localizes to the nuclear periphery of all cell types except sperm, and in embryonic and some adult cells is visible in the nuclear interior; LMN-1 binds mitotic chromosomes and histone H2A in a manner that requires its predicted nuclear localization signal, KRRR. | Paper_evidence | WBPaper00004416 | |||||
| WBPaper00005158 | |||||||||
| WBPaper00028870 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 24 Feb 2009 00:00:00 | ||||||||
| Automated_description | Enables histone binding activity; identical protein binding activity; and structural molecule activity. Involved in several processes, including cellular localization; determination of adult lifespan; and regulation of cell cycle. Located in nuclear envelope and nuclear periphery. Expressed in several structures, including ventral cord blast cell. Used to study Emery-Dreifuss muscular dystrophy; congenital muscular dystrophy; and progeria. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2B1; autosomal dominant Emery-Dreifuss muscular dystrophy 2; autosomal recessive Emery-Dreifuss muscular dystrophy 3; brain disease (multiple); congenital muscular dystrophy due to LMNA mutation; and intrinsic cardiomyopathy (multiple). Is an ortholog of human LMNA (lamin A/C). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:3911 | Homo sapiens | Paper_evidence | WBPaper00032926 | ||||
| Curator_confirmed | WBPerson38202 | ||||||||
| Date_last_updated | 24 May 2018 00:00:00 | ||||||||
| DOID:11726 | Homo sapiens | Paper_evidence | WBPaper00040258 | ||||||
| WBPaper00038510 | |||||||||
| Accession_evidence | OMIM | 181350 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 26 Jul 2023 00:00:00 | ||||||||
| DOID:0050557 | Homo sapiens | Paper_evidence | WBPaper00040268 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 04 Feb 2013 00:00:00 | ||||||||
| Potential_model (25) | |||||||||
| Models_disease_in_annotation | WBDOannot00000297 | ||||||||
| Models_disease_asserted | WBDOannot00000298 | ||||||||
| WBDOannot00000531 | |||||||||
| WBDOannot00000541 | |||||||||
| WBDOannot00001395 | |||||||||
| Molecular_info | Corresponding_CDS | DY3.2 | |||||||
| Corresponding_transcript | DY3.2.1 | ||||||||
| Other_sequence (14) | |||||||||
| Associated_feature (18) | |||||||||
| Experimental_info | RNAi_result (42) | ||||||||
| Expr_pattern (13) | |||||||||
| Drives_construct (13) | |||||||||
| Construct_product (17) | |||||||||
| Regulate_expr_cluster | WBPaper00050182:lmn-1(L535P)_downregulated | ||||||||
| WBPaper00050182:lmn-1(L535P)_upregulated | |||||||||
| WBPaper00059378:lmn-1(Y59C)_downregulated | |||||||||
| WBPaper00059378:lmn-1(Y59C)_upregulated | |||||||||
| Antibody (13) | |||||||||
| Microarray_results (23) | |||||||||
| Expression_cluster (148) | |||||||||
| Interaction (170) | |||||||||
| Map_info | Map | I | Position | 3.07104 | Error | 0.005882 | |||
| Positive | Positive_clone | DY3 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4741 | |||||||
| Pseudo_map_position | |||||||||
| Reference (67) | |||||||||
| Remark (2) | |||||||||
| Method | Gene |
