WormBase Tree Display for Gene: WBGene00003052

WBGene00003052 SMap: S_parent: Sequence: DY3
  Identity: Version: 1
    Name: CGC_name: lmn-1
      Sequence_name: DY3.2
      Molecular_name: DY3.2
        DY3.2.1
        CE15746
      Other_name: Lam1 Accession_evidence: EMBL X74027
        CELE_DY3.2 Accession_evidence: NDB BX284601
      Public_name: lmn-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:30 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: lmn
    Allele (48)
    Strain: WBStrain00026339
      WBStrain00026341
      WBStrain00026343
      WBStrain00040720
      WBStrain00002790
      WBStrain00026345
      WBStrain00034808
    Component_of_genotype: WBGenotype00000131
      WBGenotype00000150
    RNASeq_FPKM (74)
    GO_annotation (36)
    Ortholog: WBGene00060006 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00033322 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00151028 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00128699 Caenorhabditis japonica From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00223334 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g9223 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g7430 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g10144 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g1596 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g9586 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g7740 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g5538 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g8715 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g6155 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g24248 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00584.g12487 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cang_2012_03_13_08783.g21705 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-lmn-1 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold630.g20533 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_01731.g22780 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_05073 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_002532 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g12020 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g23257 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_10124610 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrI_pilon.g1669 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00237498 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00204950 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00261595 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00262017 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00287782 Trichuris muris From_analysis: WormBase-Compara
      WBGene00296617 Trichuris muris From_analysis: WormBase-Compara
      WBGene00297750 Trichuris muris From_analysis: WormBase-Compara
      WBGene00300747 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0002525 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      FB:FBgn0010397 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-990630-13 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-020424-3 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            OMA
            OrthoFinder
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-020424-2 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-020424-4 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            OMA
            OrthoFinder
            Panther
            SonicParanoid
      HGNC:6636 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:6637 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:6638 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:96794 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:96795 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:96796 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:620456 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:620522 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1563803 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
    Paralog (12)
    Structured_description: Concise_description: lmn-1 encodes the sole C. elegans nuclear lamin; lmn-1 is an essential gene that is required for a number of nuclear processes, including chromatin organization, cell cycle progression, chromosome segregation, and nuclear pore complex spacing; LMN-1 is also required for nuclear envelope localization of EMR-1/Emerin during early development; LMN-1 localizes to the nuclear periphery of all cell types except sperm, and in embryonic and some adult cells is visible in the nuclear interior; LMN-1 binds mitotic chromosomes and histone H2A in a manner that requires its predicted nuclear localization signal, KRRR. Paper_evidence (3)
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 24 Feb 2009 00:00:00
      Automated_description: Enables histone binding activity; identical protein binding activity; and structural molecule activity. Involved in several processes, including cellular localization; determination of adult lifespan; and regulation of cell cycle. Located in nuclear envelope and nuclear periphery. Expressed in several structures, including ventral cord blast cell. Used to study Emery-Dreifuss muscular dystrophy; congenital muscular dystrophy; and progeria. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2B1; autosomal dominant Emery-Dreifuss muscular dystrophy 2; autosomal recessive Emery-Dreifuss muscular dystrophy 3; brain disease (multiple); congenital muscular dystrophy due to LMNA mutation; and intrinsic cardiomyopathy (multiple). Is an ortholog of human LMNA (lamin A/C). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:3911 Homo sapiens Paper_evidence: WBPaper00032926
          Curator_confirmed: WBPerson38202
          Date_last_updated: 24 May 2018 00:00:00
      DOID:11726 Homo sapiens Paper_evidence (2)
          Accession_evidence: OMIM 181350
          Curator_confirmed: WBPerson324
          Date_last_updated: 26 Jul 2023 00:00:00
      DOID:0050557 Homo sapiens Paper_evidence: WBPaper00040268
          Curator_confirmed: WBPerson324
          Date_last_updated: 04 Feb 2013 00:00:00
    Potential_model (25)
  Models_disease_in_annotation: WBDOannot00000297
  Models_disease_asserted: WBDOannot00000298
    WBDOannot00000531
    WBDOannot00000541
    WBDOannot00001395
  Molecular_info: Corresponding_CDS: DY3.2
    Corresponding_transcript: DY3.2.1
    Other_sequence (14)
    Associated_feature (18)
  Experimental_info: RNAi_result (42)
    Expr_pattern (13)
    Drives_construct (13)
    Construct_product (17)
    Regulate_expr_cluster: WBPaper00050182:lmn-1(L535P)_downregulated
      WBPaper00050182:lmn-1(L535P)_upregulated
      WBPaper00059378:lmn-1(Y59C)_downregulated
      WBPaper00059378:lmn-1(Y59C)_upregulated
    Antibody (13)
    Microarray_results (23)
    Expression_cluster (148)
    Interaction (170)
  Map_info: Map: I Position: 3.07104 Error: 0.005882
    Positive: Positive_clone: DY3 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4741
    Pseudo_map_position
  Reference (67)
  Remark: Sequence connection based on email from Wen
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene