WormBase Tree Display for Gene: WBGene00003052
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WBGene00003052 | SMap | S_parent | Sequence | DY3 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | lmn | ||||||
Allele (48) | |||||||
Strain | WBStrain00026339 | ||||||
WBStrain00026341 | |||||||
WBStrain00026343 | |||||||
WBStrain00040720 | |||||||
WBStrain00002790 | |||||||
WBStrain00026345 | |||||||
WBStrain00034808 | |||||||
Component_of_genotype | WBGenotype00000131 | ||||||
WBGenotype00000150 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (36) | |||||||
Ortholog (49) | |||||||
Paralog (12) | |||||||
Structured_description | Concise_description | lmn-1 encodes the sole C. elegans nuclear lamin; lmn-1 is an essential gene that is required for a number of nuclear processes, including chromatin organization, cell cycle progression, chromosome segregation, and nuclear pore complex spacing; LMN-1 is also required for nuclear envelope localization of EMR-1/Emerin during early development; LMN-1 localizes to the nuclear periphery of all cell types except sperm, and in embryonic and some adult cells is visible in the nuclear interior; LMN-1 binds mitotic chromosomes and histone H2A in a manner that requires its predicted nuclear localization signal, KRRR. | Paper_evidence | WBPaper00004416 | |||
WBPaper00005158 | |||||||
WBPaper00028870 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 24 Feb 2009 00:00:00 | ||||||
Automated_description | Enables histone binding activity; identical protein binding activity; and structural molecule activity. Involved in several processes, including cellular localization; determination of adult lifespan; and regulation of cell cycle. Located in nuclear envelope and nuclear periphery. Expressed in several structures, including ventral cord blast cell. Used to study Emery-Dreifuss muscular dystrophy; congenital muscular dystrophy; and progeria. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2B1; autosomal dominant Emery-Dreifuss muscular dystrophy 2; autosomal recessive Emery-Dreifuss muscular dystrophy 3; brain disease (multiple); congenital muscular dystrophy due to LMNA mutation; and intrinsic cardiomyopathy (multiple). Is an ortholog of human LMNA (lamin A/C). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:3911 | Homo sapiens | Paper_evidence | WBPaper00032926 | ||
Curator_confirmed | WBPerson38202 | ||||||
Date_last_updated | 24 May 2018 00:00:00 | ||||||
DOID:11726 | Homo sapiens | Paper_evidence | WBPaper00040258 | ||||
WBPaper00038510 | |||||||
Accession_evidence | OMIM | 181350 | |||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 26 Jul 2023 00:00:00 | ||||||
DOID:0050557 | Homo sapiens | Paper_evidence | WBPaper00040268 | ||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 04 Feb 2013 00:00:00 | ||||||
Potential_model | DOID:0111450 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6638) | |||
DOID:0110156 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) | ||||
DOID:0060785 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6637) | ||||
DOID:0111584 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) | ||||
DOID:0070370 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) | ||||
DOID:6713 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) | ||||
DOID:0070296 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6637,HGNC:6638) | ||||
DOID:11712 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) | ||||
DOID:0070202 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) | ||||
DOID:0050431 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) | ||||
DOID:0070247 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) | ||||
DOID:0110425 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) | ||||
DOID:0050440 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) | ||||
DOID:0070248 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) | ||||
DOID:0081128 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) | ||||
DOID:9352 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) | ||||
DOID:0110640 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) | ||||
DOID:5688 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) | ||||
DOID:3911 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) | ||||
DOID:11726 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) | ||||
DOID:0080334 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) | ||||
DOID:0050820 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) | ||||
DOID:12930 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) | ||||
DOID:811 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) | ||||
DOID:0080299 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6638) | ||||
Models_disease_in_annotation | WBDOannot00000297 | ||||||
Models_disease_asserted | WBDOannot00000298 | ||||||
WBDOannot00000531 | |||||||
WBDOannot00000541 | |||||||
WBDOannot00001395 | |||||||
Molecular_info | Corresponding_CDS | DY3.2 | |||||
Corresponding_transcript | DY3.2.1 | ||||||
Other_sequence (14) | |||||||
Associated_feature (18) | |||||||
Experimental_info | RNAi_result (42) | ||||||
Expr_pattern (13) | |||||||
Drives_construct (13) | |||||||
Construct_product (17) | |||||||
Regulate_expr_cluster | WBPaper00050182:lmn-1(L535P)_downregulated | ||||||
WBPaper00050182:lmn-1(L535P)_upregulated | |||||||
WBPaper00059378:lmn-1(Y59C)_downregulated | |||||||
WBPaper00059378:lmn-1(Y59C)_upregulated | |||||||
Antibody (13) | |||||||
Microarray_results (23) | |||||||
Expression_cluster (148) | |||||||
Interaction (170) | |||||||
Map_info | Map | I | Position | 3.07104 | Error | 0.005882 | |
Positive | Positive_clone | DY3 | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Mapping_data | Multi_point | 4741 | |||||
Pseudo_map_position | |||||||
Reference (67) | |||||||
Remark | Sequence connection based on email from Wen | ||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |