WBGene00003052 | SMap | S_parent | Sequence | DY3 |
| Identity | Version | 1 |
| | Name | CGC_name | lmn-1 |
| | | Sequence_name | DY3.2 |
| | | Molecular_name | DY3.2 |
| | | | DY3.2.1 |
| | | | CE15746 |
| | | Other_name | Lam1 | Accession_evidence | EMBL | X74027 |
| | | | CELE_DY3.2 | Accession_evidence | NDB | BX284601 |
| | | Public_name | lmn-1 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | lmn |
| | Allele (48) |
| | Strain | WBStrain00026339 |
| | | WBStrain00026341 |
| | | WBStrain00026343 |
| | | WBStrain00040720 |
| | | WBStrain00002790 |
| | | WBStrain00026345 |
| | | WBStrain00034808 |
| | Component_of_genotype | WBGenotype00000131 |
| | | WBGenotype00000150 |
| | RNASeq_FPKM (74) |
| | GO_annotation (36) |
| | Ortholog (49) |
| | Paralog (12) |
| | Structured_description | Concise_description | lmn-1 encodes the sole C. elegans nuclear lamin; lmn-1 is an essential gene that is required for a number of nuclear processes, including chromatin organization, cell cycle progression, chromosome segregation, and nuclear pore complex spacing; LMN-1 is also required for nuclear envelope localization of EMR-1/Emerin during early development; LMN-1 localizes to the nuclear periphery of all cell types except sperm, and in embryonic and some adult cells is visible in the nuclear interior; LMN-1 binds mitotic chromosomes and histone H2A in a manner that requires its predicted nuclear localization signal, KRRR. | Paper_evidence | WBPaper00004416 |
| | | | | | WBPaper00005158 |
| | | | | | WBPaper00028870 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 24 Feb 2009 00:00:00 |
| | | Automated_description | Enables histone binding activity; identical protein binding activity; and structural molecule activity. Involved in several processes, including cellular localization; determination of adult lifespan; and regulation of cell cycle. Located in nuclear envelope and nuclear periphery. Expressed in several structures, including ventral cord blast cell. Used to study Emery-Dreifuss muscular dystrophy; congenital muscular dystrophy; and progeria. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2B1; autosomal dominant Emery-Dreifuss muscular dystrophy 2; autosomal recessive Emery-Dreifuss muscular dystrophy 3; brain disease (multiple); congenital muscular dystrophy due to LMNA mutation; and intrinsic cardiomyopathy (multiple). Is an ortholog of human LMNA (lamin A/C). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Experimental_model | DOID:3911 | Homo sapiens | Paper_evidence | WBPaper00032926 |
| | | | | Curator_confirmed | WBPerson38202 |
| | | | | Date_last_updated | 24 May 2018 00:00:00 |
| | | DOID:11726 | Homo sapiens | Paper_evidence | WBPaper00040258 |
| | | | | | WBPaper00038510 |
| | | | | Accession_evidence | OMIM | 181350 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 26 Jul 2023 00:00:00 |
| | | DOID:0050557 | Homo sapiens | Paper_evidence | WBPaper00040268 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 04 Feb 2013 00:00:00 |
| | Potential_model | DOID:0111450 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6638) |
| | | DOID:0110156 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) |
| | | DOID:0060785 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6637) |
| | | DOID:0111584 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) |
| | | DOID:0070370 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) |
| | | DOID:6713 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) |
| | | DOID:0070296 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6637,HGNC:6638) |
| | | DOID:11712 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) |
| | | DOID:0070202 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) |
| | | DOID:0050431 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) |
| | | DOID:0070247 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) |
| | | DOID:0110425 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) |
| | | DOID:0050440 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) |
| | | DOID:0070248 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) |
| | | DOID:0081128 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) |
| | | DOID:9352 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) |
| | | DOID:0110640 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) |
| | | DOID:5688 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) |
| | | DOID:3911 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) |
| | | DOID:11726 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) |
| | | DOID:0080334 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) |
| | | DOID:0050820 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) |
| | | DOID:12930 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) |
| | | DOID:811 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6636) |
| | | DOID:0080299 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6638) |
| Models_disease_in_annotation | WBDOannot00000297 |
| Models_disease_asserted | WBDOannot00000298 |
| | WBDOannot00000531 |
| | WBDOannot00000541 |
| | WBDOannot00001395 |
| Molecular_info | Corresponding_CDS | DY3.2 |
| | Corresponding_transcript | DY3.2.1 |
| | Other_sequence (14) |
| | Associated_feature (18) |
| Experimental_info | RNAi_result (42) |
| | Expr_pattern (13) |
| | Drives_construct (13) |
| | Construct_product (17) |
| | Regulate_expr_cluster | WBPaper00050182:lmn-1(L535P)_downregulated |
| | | WBPaper00050182:lmn-1(L535P)_upregulated |
| | | WBPaper00059378:lmn-1(Y59C)_downregulated |
| | | WBPaper00059378:lmn-1(Y59C)_upregulated |
| | Antibody (13) |
| | Microarray_results (23) |
| | Expression_cluster (148) |
| | Interaction | WBInteraction000007879 |
| | | WBInteraction000028342 |
| | | WBInteraction000029158 |
| | | WBInteraction000030811 |
| | | WBInteraction000030970 |
| | | WBInteraction000031113 |
| | | WBInteraction000051445 |
| | | WBInteraction000051446 |
| | | WBInteraction000118365 |
| | | WBInteraction000118805 |
| | | WBInteraction000118806 |
| | | WBInteraction000118807 |
| | | WBInteraction000118808 |
| | | WBInteraction000118809 |
| | | WBInteraction000118810 |
| | | WBInteraction000118811 |
| | | WBInteraction000118812 |
| | | WBInteraction000118813 |
| | | WBInteraction000118814 |
| | | WBInteraction000118815 |
| | | WBInteraction000118816 |
| | | WBInteraction000118817 |
| | | WBInteraction000118819 |
| | | WBInteraction000118820 |
| | | WBInteraction000118821 |
| | | WBInteraction000119969 |
| | | WBInteraction000122741 |
| | | WBInteraction000135561 |
| | | WBInteraction000135562 |
| | | WBInteraction000135563 |
| | | WBInteraction000135564 |
| | | WBInteraction000137980 |
| | | WBInteraction000137981 |
| | | WBInteraction000140828 |
| | | WBInteraction000140840 |
| | | WBInteraction000140863 |
| | | WBInteraction000140874 |
| | | WBInteraction000140875 |
| | | WBInteraction000140876 |
| | | WBInteraction000140877 |
| | | WBInteraction000140878 |
| | | WBInteraction000140879 |
| | | WBInteraction000143153 |
| | | WBInteraction000145302 |
| | | WBInteraction000147235 |
| | | WBInteraction000151081 |
| | | WBInteraction000160383 |
| | | WBInteraction000160393 |
| | | WBInteraction000162547 |
| | | WBInteraction000162945 |
| | | WBInteraction000172126 |
| | | WBInteraction000173510 |
| | | WBInteraction000175528 |
| | | WBInteraction000272801 |
| | | WBInteraction000343521 |
| | | WBInteraction000361710 |
| | | WBInteraction000361711 |
| | | WBInteraction000362904 |
| | | WBInteraction000363565 |
| | | WBInteraction000371828 |
| | | WBInteraction000384217 |
| | | WBInteraction000384591 |
| | | WBInteraction000389959 |
| | | WBInteraction000396078 |
| | | WBInteraction000398289 |
| | | WBInteraction000409859 |
| | | WBInteraction000423250 |
| | | WBInteraction000441847 |
| | | WBInteraction000501951 |
| | | WBInteraction000502598 |
| | | WBInteraction000503003 |
| | | WBInteraction000512320 |
| | | WBInteraction000512332 |
| | | WBInteraction000512333 |
| | | WBInteraction000512336 |
| | | WBInteraction000512342 |
| | | WBInteraction000512397 |
| | | WBInteraction000512398 |
| | | WBInteraction000512399 |
| | | WBInteraction000512751 |
| | | WBInteraction000512753 |
| | | WBInteraction000516133 |
| | | WBInteraction000522845 |
| | | WBInteraction000522915 |
| | | WBInteraction000522916 |
| | | WBInteraction000522938 |
| | | WBInteraction000522965 |
| | | WBInteraction000522974 |
| | | WBInteraction000522998 |
| | | WBInteraction000523055 |
| | | WBInteraction000523072 |
| | | WBInteraction000523086 |
| | | WBInteraction000523089 |
| | | WBInteraction000523096 |
| | | WBInteraction000523119 |
| | | WBInteraction000523186 |
| | | WBInteraction000523237 |
| | | WBInteraction000523276 |
| | | WBInteraction000523281 |
| | | WBInteraction000523310 |
| | | WBInteraction000523364 |
| | | WBInteraction000523382 |
| | | WBInteraction000523424 |
| | | WBInteraction000523456 |
| | | WBInteraction000523470 |
| | | WBInteraction000523480 |
| | | WBInteraction000523541 |
| | | WBInteraction000523559 |
| | | WBInteraction000524001 |
| | | WBInteraction000525956 |
| | | WBInteraction000528112 |
| | | WBInteraction000536492 |
| | | WBInteraction000536827 |
| | | WBInteraction000541662 |
| | | WBInteraction000542728 |
| | | WBInteraction000542934 |
| | | WBInteraction000543641 |
| | | WBInteraction000543725 |
| | | WBInteraction000543933 |
| | | WBInteraction000543944 |
| | | WBInteraction000544001 |
| | | WBInteraction000544009 |
| | | WBInteraction000544535 |
| | | WBInteraction000544537 |
| | | WBInteraction000544570 |
| | | WBInteraction000544571 |
| | | WBInteraction000544598 |
| | | WBInteraction000547653 |
| | | WBInteraction000549744 |
| | | WBInteraction000550335 |
| | | WBInteraction000551384 |
| | | WBInteraction000551385 |
| | | WBInteraction000551387 |
| | | WBInteraction000552319 |
| | | WBInteraction000552529 |
| | | WBInteraction000553985 |
| | | WBInteraction000554774 |
| | | WBInteraction000556734 |
| | | WBInteraction000556969 |
| | | WBInteraction000556970 |
| | | WBInteraction000557552 |
| | | WBInteraction000558266 |
| | | WBInteraction000558267 |
| | | WBInteraction000560447 |
| | | WBInteraction000560448 |
| | | WBInteraction000562264 |
| | | WBInteraction000562391 |
| | | WBInteraction000562556 |
| | | WBInteraction000562557 |
| | | WBInteraction000562558 |
| | | WBInteraction000562633 |
| | | WBInteraction000562731 |
| | | WBInteraction000564028 |
| | | WBInteraction000566404 |
| | | WBInteraction000566683 |
| | | WBInteraction000570443 |
| | | WBInteraction000570685 |
| | | WBInteraction000570686 |
| | | WBInteraction000570687 |
| | | WBInteraction000570729 |
| | | WBInteraction000571673 |
| | | WBInteraction000571823 |
| | | WBInteraction000572443 |
| | | WBInteraction000573466 |
| | | WBInteraction000576820 |
| | | WBInteraction000577635 |
| | | WBInteraction000579009 |
| | | WBInteraction000579469 |
| | | WBInteraction000580138 |
| | | WBInteraction000585918 |
| Map_info | Map | I | Position | 3.07104 | Error | 0.005882 |
| | Positive | Positive_clone | DY3 | Inferred_automatically | From CDS info |
| | | | | | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4741 |
| | Pseudo_map_position |
| Reference (67) |
| Remark | Sequence connection based on email from Wen |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |