WormBase Tree Display for Gene: WBGene00003052

WBGene00003052 SMap: S_parent: Sequence: DY3
  Identity: Version: 1
    Name: CGC_name: lmn-1
      Sequence_name: DY3.2
      Molecular_name: DY3.2
        DY3.2.1
        CE15746
      Other_name: Lam1 Accession_evidence: EMBL X74027
        CELE_DY3.2 Accession_evidence: NDB BX284601
      Public_name: lmn-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:30 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: lmn
    Allele (48)
    Strain: WBStrain00026339
      WBStrain00026341
      WBStrain00026343
      WBStrain00040720
      WBStrain00002790
      WBStrain00026345
      WBStrain00034808
    Component_of_genotype: WBGenotype00000131
      WBGenotype00000150
    RNASeq_FPKM (74)
    GO_annotation (36)
    Ortholog (49)
    Paralog (12)
    Structured_description: Concise_description: lmn-1 encodes the sole C. elegans nuclear lamin; lmn-1 is an essential gene that is required for a number of nuclear processes, including chromatin organization, cell cycle progression, chromosome segregation, and nuclear pore complex spacing; LMN-1 is also required for nuclear envelope localization of EMR-1/Emerin during early development; LMN-1 localizes to the nuclear periphery of all cell types except sperm, and in embryonic and some adult cells is visible in the nuclear interior; LMN-1 binds mitotic chromosomes and histone H2A in a manner that requires its predicted nuclear localization signal, KRRR. Paper_evidence: WBPaper00004416
            WBPaper00005158
            WBPaper00028870
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 24 Feb 2009 00:00:00
      Automated_description: Enables histone binding activity; identical protein binding activity; and structural molecule activity. Involved in several processes, including cellular localization; determination of adult lifespan; and regulation of cell cycle. Located in nuclear envelope and nuclear periphery. Expressed in several structures, including ventral cord blast cell. Used to study Emery-Dreifuss muscular dystrophy; congenital muscular dystrophy; and progeria. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2B1; autosomal dominant Emery-Dreifuss muscular dystrophy 2; autosomal recessive Emery-Dreifuss muscular dystrophy 3; brain disease (multiple); congenital muscular dystrophy due to LMNA mutation; and intrinsic cardiomyopathy (multiple). Is an ortholog of human LMNA (lamin A/C). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:3911 Homo sapiens Paper_evidence: WBPaper00032926
          Curator_confirmed: WBPerson38202
          Date_last_updated: 24 May 2018 00:00:00
      DOID:11726 Homo sapiens Paper_evidence: WBPaper00040258
            WBPaper00038510
          Accession_evidence: OMIM 181350
          Curator_confirmed: WBPerson324
          Date_last_updated: 26 Jul 2023 00:00:00
      DOID:0050557 Homo sapiens Paper_evidence: WBPaper00040268
          Curator_confirmed: WBPerson324
          Date_last_updated: 04 Feb 2013 00:00:00
    Potential_model (25)
  Models_disease_in_annotation: WBDOannot00000297
  Models_disease_asserted: WBDOannot00000298
    WBDOannot00000531
    WBDOannot00000541
    WBDOannot00001395
  Molecular_info: Corresponding_CDS: DY3.2
    Corresponding_transcript: DY3.2.1
    Other_sequence (14)
    Associated_feature (18)
  Experimental_info: RNAi_result (42)
    Expr_pattern (13)
    Drives_construct (13)
    Construct_product (17)
    Regulate_expr_cluster: WBPaper00050182:lmn-1(L535P)_downregulated
      WBPaper00050182:lmn-1(L535P)_upregulated
      WBPaper00059378:lmn-1(Y59C)_downregulated
      WBPaper00059378:lmn-1(Y59C)_upregulated
    Antibody (13)
    Microarray_results (23)
    Expression_cluster (148)
    Interaction: WBInteraction000007879
      WBInteraction000028342
      WBInteraction000029158
      WBInteraction000030811
      WBInteraction000030970
      WBInteraction000031113
      WBInteraction000051445
      WBInteraction000051446
      WBInteraction000118365
      WBInteraction000118805
      WBInteraction000118806
      WBInteraction000118807
      WBInteraction000118808
      WBInteraction000118809
      WBInteraction000118810
      WBInteraction000118811
      WBInteraction000118812
      WBInteraction000118813
      WBInteraction000118814
      WBInteraction000118815
      WBInteraction000118816
      WBInteraction000118817
      WBInteraction000118819
      WBInteraction000118820
      WBInteraction000118821
      WBInteraction000119969
      WBInteraction000122741
      WBInteraction000135561
      WBInteraction000135562
      WBInteraction000135563
      WBInteraction000135564
      WBInteraction000137980
      WBInteraction000137981
      WBInteraction000140828
      WBInteraction000140840
      WBInteraction000140863
      WBInteraction000140874
      WBInteraction000140875
      WBInteraction000140876
      WBInteraction000140877
      WBInteraction000140878
      WBInteraction000140879
      WBInteraction000143153
      WBInteraction000145302
      WBInteraction000147235
      WBInteraction000151081
      WBInteraction000160383
      WBInteraction000160393
      WBInteraction000162547
      WBInteraction000162945
      WBInteraction000172126
      WBInteraction000173510
      WBInteraction000175528
      WBInteraction000272801
      WBInteraction000343521
      WBInteraction000361710
      WBInteraction000361711
      WBInteraction000362904
      WBInteraction000363565
      WBInteraction000371828
      WBInteraction000384217
      WBInteraction000384591
      WBInteraction000389959
      WBInteraction000396078
      WBInteraction000398289
      WBInteraction000409859
      WBInteraction000423250
      WBInteraction000441847
      WBInteraction000501951
      WBInteraction000502598
      WBInteraction000503003
      WBInteraction000512320
      WBInteraction000512332
      WBInteraction000512333
      WBInteraction000512336
      WBInteraction000512342
      WBInteraction000512397
      WBInteraction000512398
      WBInteraction000512399
      WBInteraction000512751
      WBInteraction000512753
      WBInteraction000516133
      WBInteraction000522845
      WBInteraction000522915
      WBInteraction000522916
      WBInteraction000522938
      WBInteraction000522965
      WBInteraction000522974
      WBInteraction000522998
      WBInteraction000523055
      WBInteraction000523072
      WBInteraction000523086
      WBInteraction000523089
      WBInteraction000523096
      WBInteraction000523119
      WBInteraction000523186
      WBInteraction000523237
      WBInteraction000523276
      WBInteraction000523281
      WBInteraction000523310
      WBInteraction000523364
      WBInteraction000523382
      WBInteraction000523424
      WBInteraction000523456
      WBInteraction000523470
      WBInteraction000523480
      WBInteraction000523541
      WBInteraction000523559
      WBInteraction000524001
      WBInteraction000525956
      WBInteraction000528112
      WBInteraction000536492
      WBInteraction000536827
      WBInteraction000541662
      WBInteraction000542728
      WBInteraction000542934
      WBInteraction000543641
      WBInteraction000543725
      WBInteraction000543933
      WBInteraction000543944
      WBInteraction000544001
      WBInteraction000544009
      WBInteraction000544535
      WBInteraction000544537
      WBInteraction000544570
      WBInteraction000544571
      WBInteraction000544598
      WBInteraction000547653
      WBInteraction000549744
      WBInteraction000550335
      WBInteraction000551384
      WBInteraction000551385
      WBInteraction000551387
      WBInteraction000552319
      WBInteraction000552529
      WBInteraction000553985
      WBInteraction000554774
      WBInteraction000556734
      WBInteraction000556969
      WBInteraction000556970
      WBInteraction000557552
      WBInteraction000558266
      WBInteraction000558267
      WBInteraction000560447
      WBInteraction000560448
      WBInteraction000562264
      WBInteraction000562391
      WBInteraction000562556
      WBInteraction000562557
      WBInteraction000562558
      WBInteraction000562633
      WBInteraction000562731
      WBInteraction000564028
      WBInteraction000566404
      WBInteraction000566683
      WBInteraction000570443
      WBInteraction000570685
      WBInteraction000570686
      WBInteraction000570687
      WBInteraction000570729
      WBInteraction000571673
      WBInteraction000571823
      WBInteraction000572443
      WBInteraction000573466
      WBInteraction000576820
      WBInteraction000577635
      WBInteraction000579009
      WBInteraction000579469
      WBInteraction000580138
      WBInteraction000585918
  Map_info: Map: I Position: 3.07104 Error: 0.005882
    Positive: Positive_clone: DY3 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4741
    Pseudo_map_position
  Reference (67)
  Remark: Sequence connection based on email from Wen
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene