WormBase Tree Display for Gene: WBGene00003039
expand all nodes | collapse all nodes | view schema
WBGene00003039 | SMap | S_parent | Sequence | F56A12 | |||
---|---|---|---|---|---|---|---|
Identity | Version | 3 | |||||
Name | CGC_name | mir-48 | Paper_evidence | WBPaper00026781 | |||
Person_evidence | WBPerson18 | ||||||
Sequence_name | F56A12.3 | ||||||
Molecular_name | F56A12.3 | ||||||
F56A12.3a | |||||||
F56A12.3b | |||||||
Other_name | lin-58 | Person_evidence | WBPerson261 | ||||
Cel-Let-7-P6 | Remark | MirGeneDB 2.1 import | |||||
CELE_F56A12.3 | Accession_evidence | NDB | BX284605 | ||||
Public_name | mir-48 | ||||||
DB_info | Database | miRBase | acc | MI0000019 | |||
SignaLink | mirna | cel-mir-48 | |||||
MirGeneDB | cel | Cel-Let-7-P6 | |||||
NDB | locus_tag | CELE_F56A12.3 | |||||
NCBI | gene | 260115 | |||||
RefSeq | protein | NR_000793.2 | |||||
RNAcentral | URSid | URS000000076D | |||||
URS00001CC103 | |||||||
URS000031C21C | |||||||
Species | Caenorhabditis elegans | ||||||
History (2) | |||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001265 | |||||
Gene_class | mir | ||||||
Allele (13) | |||||||
Legacy_information | [Abrahante JE, Miller EA, Rougvie AE] Both alleles produce precocious adult alae, at L3-to-L4 molt. Less distinct that precocious alae in lin-14(lf). ve33 stronger allele, semidominant. Mutations identified as suppressors of lin-4 suppression of col-19::GFP, veIs13 reporter. | ||||||
Strain | WBStrain00027436 | ||||||
WBStrain00027438 | |||||||
WBStrain00040222 | |||||||
WBStrain00051626 | |||||||
WBStrain00051625 | |||||||
In_cluster | LET-7 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation | 00106183 | ||||||
00106184 | |||||||
00106185 | |||||||
Structured_description | Concise_description | mir-48 encodes a microRNA (miRNA); mir-48 was identified in screens for new heterochronic loci required for the proper temporal control of specific postembryonic cell divisions; mutations in mir-48 result in precocious terminal differentiation of hypodermal seam cells and secretion of adult cuticle one stage too early. | Paper_evidence | WBPaper00003119 | |||
WBPaper00026781 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 11 Jul 2007 00:00:00 | ||||||
Automated_description | Involved in miRNA-mediated gene silencing by inhibition of translation and positive regulation of development, heterochronic. Expressed in P5.p hermaphrodite; P7.p hermaphrodite; RID; and seam cell. Used to study Parkinson's disease. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:14330 | Homo sapiens | Paper_evidence | WBPaper00035654 | ||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 06 Jan 2014 00:00:00 | ||||||
Disease_relevance | mir-48 is a small non-protein coding RNA that belongs to the let-7 family; microRNA expression profiling studies in an elegans transgenic model of Parkinson''s disease, where A53T alpha-synuclein is overexpressed, indicate that elegans mir-48 and mir-84 are underexpressed; also mir-48 is underexpressed in a pdr-1 mutant; pdr-1 is orthologous to human PARKIN, which is associated with the juvenile form of Parkinson disease, adenocarcinomas of the ovary and lung, and susceptibility to Leprosy. | Homo sapiens | Paper_evidence | WBPaper00035654 | |||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 06 Jan 2014 00:00:00 | ||||||
Models_disease_in_annotation | WBDOannot00000263 | ||||||
Molecular_info | Corresponding_transcript | F56A12.3 | |||||
F56A12.3a | |||||||
F56A12.3b | |||||||
Associated_feature | WBsf034323 | ||||||
WBsf979127 | |||||||
WBsf1001988 | |||||||
WBsf1001989 | |||||||
WBsf1001990 | |||||||
WBsf1020826 | |||||||
WBsf1020827 | |||||||
Experimental_info | Expr_pattern (11) | ||||||
Drives_construct | WBCnstr00004855 | ||||||
WBCnstr00004856 | |||||||
WBCnstr00004857 | |||||||
WBCnstr00004858 | |||||||
WBCnstr00005523 | |||||||
WBCnstr00011650 | |||||||
WBCnstr00020505 | |||||||
Construct_product | WBCnstr00004855 | ||||||
WBCnstr00004856 | |||||||
WBCnstr00004857 | |||||||
WBCnstr00004858 | |||||||
WBCnstr00016932 | |||||||
Expression_cluster (30) | |||||||
Interaction (23) | |||||||
WBProcess | WBbiopr:00000083 | ||||||
Map_info | Map | V | Position | 6.27549 | Error | 0.003412 | |
Positive | Inside_rearr | yDf8 | |||||
nDf51 | |||||||
Positive_clone | F56A12 | Inferred_automatically | From CDS info | ||||
From sequence, transcript, pseudogene data | |||||||
Negative | Outside_rearr | yDf4 | |||||
Mapping_data | Multi_point | 3706 | |||||
5653 | |||||||
Pos_neg_data (3) | |||||||
Reference (86) | |||||||
Remark | Data extracted from Abrahante et al. (1998) | ||||||
Rfam accession number: MI0000019 | |||||||
Method | Gene |