WormBase Tree Display for Gene: WBGene00003039
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| WBGene00003039 | SMap | S_parent | Sequence | F56A12 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | mir-48 | Paper_evidence | WBPaper00026781 | |||||
| Person_evidence | WBPerson18 | ||||||||
| Sequence_name | F56A12.3 | ||||||||
| Molecular_name | F56A12.3 | ||||||||
| F56A12.3a | |||||||||
| F56A12.3b | |||||||||
| Other_name | lin-58 | Person_evidence | WBPerson261 | ||||||
| Cel-Let-7-P6 | Remark | MirGeneDB 2.1 import | |||||||
| CELE_F56A12.3 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | mir-48 | ||||||||
| DB_info | Database | miRBase | acc | MI0000019 | |||||
| SignaLink | mirna | cel-mir-48 | |||||||
| MirGeneDB | cel | Cel-Let-7-P6 | |||||||
| NDB | locus_tag | CELE_F56A12.3 | |||||||
| NCBI | gene | 260115 | |||||||
| RefSeq | protein | NR_000793.2 | |||||||
| RNAcentral | URSid | URS000000076D | |||||||
| URS00001CC103 | |||||||||
| URS000031C21C | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 19 Dec 2005 15:11:14 | WBPerson2970 | Event | Acquires_merge | WBGene00003276 | ||||
| Name_change | Sequence_name | F56A12.3 | |||||||
| Other_name | mir-48 | ||||||||
| 3 | 25 Apr 2016 10:28:20 | WBPerson2970 | Name_change | CGC_name | mir-48 | ||||
| Other_name | lin-58 | ||||||||
| Acquires_merge | WBGene00003276 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001265 | |||||||
| Gene_class | mir | ||||||||
| Allele (13) | |||||||||
| Legacy_information | [Abrahante JE, Miller EA, Rougvie AE] Both alleles produce precocious adult alae, at L3-to-L4 molt. Less distinct that precocious alae in lin-14(lf). ve33 stronger allele, semidominant. Mutations identified as suppressors of lin-4 suppression of col-19::GFP, veIs13 reporter. | ||||||||
| Strain | WBStrain00027436 | ||||||||
| WBStrain00027438 | |||||||||
| WBStrain00040222 | |||||||||
| WBStrain00051626 | |||||||||
| WBStrain00051625 | |||||||||
| In_cluster | LET-7 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00106183 | ||||||||
| 00106184 | |||||||||
| 00106185 | |||||||||
| Structured_description | Concise_description | mir-48 encodes a microRNA (miRNA); mir-48 was identified in screens for new heterochronic loci required for the proper temporal control of specific postembryonic cell divisions; mutations in mir-48 result in precocious terminal differentiation of hypodermal seam cells and secretion of adult cuticle one stage too early. | Paper_evidence | WBPaper00003119 | |||||
| WBPaper00026781 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 11 Jul 2007 00:00:00 | ||||||||
| Automated_description | Involved in miRNA-mediated gene silencing by inhibition of translation and positive regulation of development, heterochronic. Expressed in P5.p hermaphrodite; P7.p hermaphrodite; RID; and seam cell. Used to study Parkinson's disease. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:14330 | Homo sapiens | Paper_evidence | WBPaper00035654 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 06 Jan 2014 00:00:00 | ||||||||
| Disease_relevance | mir-48 is a small non-protein coding RNA that belongs to the let-7 family; microRNA expression profiling studies in an elegans transgenic model of Parkinson''s disease, where A53T alpha-synuclein is overexpressed, indicate that elegans mir-48 and mir-84 are underexpressed; also mir-48 is underexpressed in a pdr-1 mutant; pdr-1 is orthologous to human PARKIN, which is associated with the juvenile form of Parkinson disease, adenocarcinomas of the ovary and lung, and susceptibility to Leprosy. | Homo sapiens | Paper_evidence | WBPaper00035654 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 06 Jan 2014 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000263 | ||||||||
| Molecular_info | Corresponding_transcript | F56A12.3 | |||||||
| F56A12.3a | |||||||||
| F56A12.3b | |||||||||
| Associated_feature | WBsf034323 | ||||||||
| WBsf979127 | |||||||||
| WBsf1001988 | |||||||||
| WBsf1001989 | |||||||||
| WBsf1001990 | |||||||||
| WBsf1020826 | |||||||||
| WBsf1020827 | |||||||||
| Experimental_info | Expr_pattern (11) | ||||||||
| Drives_construct | WBCnstr00004855 | ||||||||
| WBCnstr00004856 | |||||||||
| WBCnstr00004857 | |||||||||
| WBCnstr00004858 | |||||||||
| WBCnstr00005523 | |||||||||
| WBCnstr00011650 | |||||||||
| WBCnstr00020505 | |||||||||
| Construct_product | WBCnstr00004855 | ||||||||
| WBCnstr00004856 | |||||||||
| WBCnstr00004857 | |||||||||
| WBCnstr00004858 | |||||||||
| WBCnstr00016932 | |||||||||
| Expression_cluster (30) | |||||||||
| Interaction (23) | |||||||||
| WBProcess | WBbiopr:00000083 | ||||||||
| Map_info | Map | V | Position | 6.27549 | Error | 0.003412 | |||
| Positive | Inside_rearr | yDf8 | |||||||
| nDf51 | |||||||||
| Positive_clone | F56A12 | Inferred_automatically | From CDS info | ||||||
| From sequence, transcript, pseudogene data | |||||||||
| Negative | Outside_rearr | yDf4 | |||||||
| Mapping_data | Multi_point | 3706 | |||||||
| 5653 | |||||||||
| Pos_neg_data | 9420 | ||||||||
| 9421 | |||||||||
| 10749 | |||||||||
| Reference (86) | |||||||||
| Remark | Data extracted from Abrahante et al. (1998) | ||||||||
| Rfam accession number: MI0000019 | |||||||||
| Method | Gene |
