WormBase Tree Display for Gene: WBGene00002979
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| WBGene00002979 | SMap | S_parent | Sequence | C46H11 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | lfe-2 | Person_evidence | WBPerson625 | |||||
| Sequence_name | C46H11.4 | ||||||||
| Molecular_name (16) | |||||||||
| Other_name | C46H11.g | Curator_confirmed | WBPerson1983 | ||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| CELE_C46H11.4 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | lfe-2 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lfe | ||||||||
| Allele (148) | |||||||||
| Legacy_information | [Clandinin T] mutations suppress let-23 sterility | ||||||||
| [C.elegansII] sy326 : suppresses sterility of let-23 mutations. [PS] | |||||||||
| Strain | WBStrain00030843 | ||||||||
| WBStrain00030855 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (14) | |||||||||
| Ortholog (44) | |||||||||
| Paralog | WBGene00014081 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00021260 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00020631 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00009262 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | lfe-2 encodes an inositol (1,4,5) triphosphate-3-kinase (IP3K); lfe-2 activity is required for normal levels of hermaphrodite fertility and for tissue-specific negative regulation of the LET-23 signaling pathway that controls spermathecal dilation and ovulation; in vitro, LFE-2 can exhibit catalytic activity, converting IP3 to IP4; an lfe-2::GFP transcriptional fusion is expressed in the adult spermatheca and in the pharynx and gut throughout larval and adult stages; misexpression of LFE-2 in gravid adults via heat shock results in ovulation defects, consistent with a role for LFE-2 in regulating this process. | Paper_evidence | WBPaper00003017 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 13 Jan 2006 00:00:00 | ||||||||
| Automated_description | Predicted to enable inositol tetrakisphosphate kinase activity and inositol-1,4,5-trisphosphate 3-kinase activity. Predicted to be involved in inositol phosphate biosynthetic process. Predicted to be located in cytoplasm and nucleus. Expressed in spermatheca. Human ortholog(s) of this gene implicated in colorectal cancer. Is an ortholog of human ITPKA (inositol-trisphosphate 3-kinase A); ITPKB (inositol-trisphosphate 3-kinase B); and ITPKC (inositol-trisphosphate 3-kinase C). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14897) | ||||
| Molecular_info | Corresponding_CDS | C46H11.4a | |||||||
| C46H11.4b | |||||||||
| C46H11.4c | |||||||||
| C46H11.4e | |||||||||
| C46H11.4f | |||||||||
| Corresponding_CDS_history | C46H11.4d:wp273 | ||||||||
| C46H11.4f:wp261 | |||||||||
| Corresponding_transcript | C46H11.4a.1 | ||||||||
| C46H11.4b.1 | |||||||||
| C46H11.4c.1 | |||||||||
| C46H11.4e.1 | |||||||||
| C46H11.4f.1 | |||||||||
| C46H11.4f.2 | |||||||||
| Other_sequence (115) | |||||||||
| Associated_feature (11) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00003167 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00062776 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00027799 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00042628 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00062771 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00007487 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00003168 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00066573 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00003166 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00042627 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr505 | ||||||||
| Expr1017641 | |||||||||
| Expr1031379 | |||||||||
| Expr1146612 | |||||||||
| Expr2013089 | |||||||||
| Expr2031321 | |||||||||
| Drives_construct | WBCnstr00012404 | ||||||||
| WBCnstr00036310 | |||||||||
| Construct_product | WBCnstr00036310 | ||||||||
| Microarray_results (47) | |||||||||
| Expression_cluster (149) | |||||||||
| Interaction (55) | |||||||||
| WBProcess | WBbiopr:00000067 | ||||||||
| Map_info | Map | I | Position | -0.423671 | Error | 0.000969 | |||
| Positive | Positive_clone | C46H11 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4461 | |||||||
| 4474 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (27) | |||||||||
| Remark | Map I | ||||||||
| lfe-2 was previously attached to C46H11.5 which has since become a splice variant of C46H11.4 | |||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
