WormBase Tree Display for Gene: WBGene00002975
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| WBGene00002975 | SMap | S_parent | Sequence | C35C5 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | lev-8 | Paper_evidence | WBPaper00025035 | |||||
| Person_evidence | WBPerson368 | ||||||||
| Sequence_name | C35C5.5 | ||||||||
| Molecular_name | C35C5.5 | ||||||||
| C35C5.5.1 | |||||||||
| CE34160 | |||||||||
| Other_name | acr-13 | CGC_data_submission | |||||||
| CELE_C35C5.5 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | lev-8 | ||||||||
| DB_info | Database | AceView | gene | XM179 | |||||
| WormQTL | gene | WBGene00002975 | |||||||
| WormFlux | gene | WBGene00002975 | |||||||
| NDB | locus_tag | CELE_C35C5.5 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00002975|UniProtKB=Q93329 | |||||||
| family | PTHR18945 | ||||||||
| NCBI | gene | 191600 | |||||||
| RefSeq | protein | NM_077531.7 | |||||||
| TrEMBL | UniProtAcc | Q93329 | |||||||
| UniProt_GCRP | UniProtAcc | Q93329 | |||||||
| OMIM | gene | 100690 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 13 Apr 2005 09:16:49 | WBPerson2970 | Event | Acquires_merge | WBGene00000052 | ||||
| Name_change | Other_name | acr-13 | |||||||
| Acquires_merge | WBGene00000052 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lev | ||||||||
| Reference_allele | WBVar00275210 | ||||||||
| Allele (39) | |||||||||
| Legacy_information | x15 : almost normal movement in absence of drug weakly resistant to 1 mM levamisole : body contracts but head does not; more resistant at 25x. ES2. NA1. | ||||||||
| [C.elegansII] x15 : almost normal movement in absence of drug, weakly resistant to 1 mM levamisole; body contracts but head does not; more resistant at 25C. ES2. NA1. [Lewis et al. 1980, 1987; ZZ] | |||||||||
| Strain | WBStrain00036271 | ||||||||
| WBStrain00040920 | |||||||||
| WBStrain00035007 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (27) | |||||||||
| Ortholog (54) | |||||||||
| Paralog (100) | |||||||||
| Structured_description | Concise_description | lev-8 encodes a novel nicotinic acetylcholine receptor (nAChR) alpha subunit that is a member of the ACR-8 group of nAChR subunits; LEV-8 activity is required for normal rates of pharyngeal pumping and for fully wild-type responses (increased egg laying and body wall muscle contraction) to the nAChR agonist and antihelmintic levamisole; expression of a LEV-8::GFP reporter construct begins at the L1 larval stage and is detected in neurons, body wall and uterine muscle cells, and socket cells of the IL and OL mechanosensory neurons; expression in body wall muscles is strongest in the anterior, consistent with increased levamisole resistance of head, or anterior, muscles seen in lev-8 mutant animals. | Paper_evidence | WBPaper00000484 | |||||
| WBPaper00000998 | |||||||||
| WBPaper00003425 | |||||||||
| WBPaper00004660 | |||||||||
| WBPaper00005223 | |||||||||
| WBPaper00025035 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 18 Jan 2006 00:00:00 | ||||||||
| Automated_description | Predicted to enable acetylcholine-gated monoatomic cation-selective channel activity. Predicted to be involved in excitatory postsynaptic potential and monoatomic ion transmembrane transport. Predicted to be located in neuron projection and synapse. Expressed in several structures, including DD neuron; anal depressor muscle; ganglia; head neurons; and uterine-vulval cell. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 1A and congenital myasthenic syndrome 1B. Is an ortholog of human CHRNA1 (cholinergic receptor nicotinic alpha 1 subunit). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0110663 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1955) | ||||
| DOID:0110662 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1955) | ||||||
| Molecular_info | Corresponding_CDS | C35C5.5 | |||||||
| Corresponding_CDS_history | C35C5.5:wp102 | ||||||||
| Corresponding_transcript | C35C5.5.1 | ||||||||
| Other_sequence | FK806934.1 | ||||||||
| Acan_isotig20620 | |||||||||
| FK801476.1 | |||||||||
| JI179975.1 | |||||||||
| Oden_isotig22669 | |||||||||
| JI173647.1 | |||||||||
| Associated_feature | WBsf663367 | ||||||||
| WBsf1007041 | |||||||||
| WBsf1023894 | |||||||||
| WBsf236395 | |||||||||
| WBsf236396 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00102760 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00029572 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00066393 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00041967 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr3225 | ||||||||
| Expr3706 | |||||||||
| Expr7308 | |||||||||
| Expr1010963 | |||||||||
| Expr1031375 | |||||||||
| Expr1145981 | |||||||||
| Expr1200290 | |||||||||
| Expr2013086 | |||||||||
| Expr2031318 | |||||||||
| Drives_construct | WBCnstr00006483 | ||||||||
| WBCnstr00011236 | |||||||||
| WBCnstr00011617 | |||||||||
| WBCnstr00012517 | |||||||||
| WBCnstr00036312 | |||||||||
| Construct_product | WBCnstr00006483 | ||||||||
| WBCnstr00011617 | |||||||||
| WBCnstr00036312 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (101) | |||||||||
| Interaction | WBInteraction000433636 | ||||||||
| WBInteraction000500357 | |||||||||
| WBInteraction000518499 | |||||||||
| WBInteraction000543442 | |||||||||
| Map_info | Map | X | Position | 4.63283 | Error | 0.083675 | |||
| Positive | Positive_clone | C35C5 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | 2_point | 236 | |||||||
| Multi_point | 230 | ||||||||
| 5432 | |||||||||
| Reference (60) | |||||||||
| Method | Gene |
