WormBase Tree Display for Gene: WBGene00002276
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| WBGene00002276 | Evidence | Paper_evidence | WBPaper00004339 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | CHROMOSOME_I | ||||||
| Identity | Version | 2 | |||||||
| Name | CGC_name | lem-3 | Paper_evidence | WBPaper00040826 | |||||
| Sequence_name | F42H11.2 | ||||||||
| Molecular_name | F42H11.2 | ||||||||
| F42H11.2.1 | |||||||||
| CE47022 | |||||||||
| Other_name | rad-1 | ||||||||
| CELE_F42H11.2 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | lem-3 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:27 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 27 Apr 2012 16:30:37 | WBPerson2970 | Event | Acquires_merge | WBGene00004288 | ||||
| Acquires_merge | WBGene00004288 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lem | ||||||||
| Reference_allele | WBVar00089071 | ||||||||
| Allele (34) | |||||||||
| Legacy_information | [C.elegansII] mn155 : extremely hypersensitive to UV, X and gamma irradiation; not hypersensitive to UV-psoralen. ES1 ME3. NA1. [Hartman and Herman 1982; Hartman and Marshall 1992;PH] | ||||||||
| Rmn155 : extremely hypersensitive to UV X and gamma irradiation. ES1 ME3. NA1. | |||||||||
| Strain | WBStrain00034246 | ||||||||
| WBStrain00047524 | |||||||||
| WBStrain00047527 | |||||||||
| WBStrain00047526 | |||||||||
| WBStrain00047525 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (60) | |||||||||
| Contained_in_operon | CEOP1548 | ||||||||
| Ortholog (38) | |||||||||
| Paralog | WBGene00019483 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| WBGene00206377 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | lem-3 encodes a protein containing ankyrin repeats, a LEM (LAP2-emerin-MAN1) domain and a GIY-YIG nuclease domain; C. elegans has three LEM domain proteins, EMR-1, LEM-2 and LEM-3, also conserved in mammals; the LEM domain binds to a conserved metazoan chromatin protein BAF (Barrier to Autointegration Factor); EMR-1 and LEM-2 bind LMN-1/lamin and BAF-1 and require lamin for their nuclear envelope localization; LEM-3 differs from EMR-1 and LEM-2 in the lack of transmembrane domains; LEM-3 exhibits DNase activity in vitro; lem-3 mutant embryos are hypersensitive to several types of DNA damage and exhibit a high degree of lethality, indicating that LEM-3 plays a role in mediating the DNA damage response; lem-3 mutations genetically interact with mutations in baf-1, suggesting that these two genes both play a role in the DNA damage response; a YFP::LEM-3 fusion protein is expressed solely in embryos, where it localizes to the cytoplasm in a foci-like pattern. | Paper_evidence | WBPaper00029260 | |||||
| WBPaper00040518 | |||||||||
| WBPaper00032468 | |||||||||
| WBPaper00040826 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson324 | |||||||||
| Date_last_updated | 12 Apr 2012 00:00:00 | ||||||||
| Automated_description | Enables DNA endonuclease activity. Involved in several processes, including DNA metabolic process; cellular response to hydroxyurea; and response to radiation. Located in several cellular components, including condensed chromosome; midbody; and mitotic spindle midzone. Expressed in embryonic cell. Is an ortholog of human ANKLE1 (ankyrin repeat and LEM domain containing 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F42H11.2 | |||||||
| Corresponding_CDS_history | F42H11.2:wp229 | ||||||||
| Corresponding_transcript | F42H11.2.1 | ||||||||
| Other_sequence | CBC15634_1 | ||||||||
| CBC01268_1 | |||||||||
| Dviv_isotig15707 | |||||||||
| Acan_isotig08802 | |||||||||
| CR05964 | |||||||||
| Dviv_isotig15706 | |||||||||
| CRC08994_1 | |||||||||
| Oden_isotig07278 | |||||||||
| Associated_feature | WBsf649493 | ||||||||
| WBsf655300 | |||||||||
| WBsf984750 | |||||||||
| WBsf984751 | |||||||||
| WBsf220101 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00032169 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00062244 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00084982 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00066057 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00014862 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00047153 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00116838 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr9965 | ||||||||
| Expr14259 | |||||||||
| Expr14260 | |||||||||
| Expr1026409 | |||||||||
| Expr1031342 | |||||||||
| Expr1151014 | |||||||||
| Expr2013045 | |||||||||
| Expr2031277 | |||||||||
| Drives_construct | WBCnstr00036338 | ||||||||
| Construct_product | WBCnstr00014446 | ||||||||
| WBCnstr00014447 | |||||||||
| WBCnstr00014448 | |||||||||
| WBCnstr00036338 | |||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (173) | |||||||||
| Interaction (21) | |||||||||
| Map_info | Map | I | Position | 3.8033 | Error | 0.000483 | |||
| Positive | Positive_clone | F42H11 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | 2_point | 478 | |||||||
| Multi_point | 360 | ||||||||
| 361 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (42) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
