WormBase Tree Display for Gene: WBGene00002271
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| WBGene00002271 | SMap | S_parent | Sequence | R07B1 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | lec-8 | |||||||
| Sequence_name | R07B1.10 | ||||||||
| Molecular_name | R07B1.10 | ||||||||
| R07B1.10.1 | |||||||||
| CE26721 | |||||||||
| Other_name | CELE_R07B1.10 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | lec-8 | ||||||||
| DB_info | Database | AceView | gene | XK469 | |||||
| WormQTL | gene | WBGene00002271 | |||||||
| WormFlux | gene | WBGene00002271 | |||||||
| NDB | locus_tag | CELE_R07B1.10 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00002271|UniProtKB=Q09610 | |||||||
| family | PTHR11346 | ||||||||
| NCBI | gene | 181198 | |||||||
| RefSeq | protein | NM_077248.6 | |||||||
| SwissProt | UniProtAcc | Q09610 | |||||||
| UniProt_GCRP | UniProtAcc | Q09610 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:27 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lec | ||||||||
| Allele (15) | |||||||||
| Legacy_information | [Arata Y] No mutants known. Encodes predicted galectin. Predicted gene R07B1.10 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00055082 | ||||||||
| 00055083 | |||||||||
| 00055084 | |||||||||
| 00055085 | |||||||||
| 00055086 | |||||||||
| 00055087 | |||||||||
| 00055088 | |||||||||
| 00105641 | |||||||||
| 00105732 | |||||||||
| 00110343 | |||||||||
| Ortholog (51) | |||||||||
| Paralog (26) | |||||||||
| Structured_description | Concise_description | lec-8 encodes a glycolipid-binding galectin; LEC-8 binds glycolipids and can inhibit Bacillus thuringiensis Cry5B from binding glycolipids; lec-8 mutants are more susceptible to Cry5B; lec-8 is expressed in the pharyngeal-intestinal valve, the intestinal-rectal valve, and in some vesicles of the intestine; lec-8 expression in the intestine is induced in response to bacterial infection and Cry5B, suggesting that LEC-8 plays a role in host defense response. | Paper_evidence | WBPaper00005382 | |||||
| WBPaper00034766 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 19 Jun 2013 00:00:00 | ||||||||
| Automated_description | Enables glycolipid binding activity. Involved in response to toxic substance. Located in cytoplasmic vesicle. Expressed in intestine; pharyngeal-intestinal valve; tail; virL; and virR. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; aortic valve stenosis; and liver cirrhosis. Is an ortholog of human LGALS3 (galectin 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0080600 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6563) | ||||
| DOID:2841 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6563) | ||||||
| DOID:5082 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6563) | ||||||
| DOID:1712 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6563) | ||||||
| Molecular_info | Corresponding_CDS | R07B1.10 | |||||||
| Corresponding_CDS_history | R07B1.10:wp40 | ||||||||
| Corresponding_transcript | R07B1.10.1 | ||||||||
| Other_sequence (330) | |||||||||
| Associated_feature | WBsf662381 | ||||||||
| WBsf236202 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00090691 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00051410 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00034675 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00075968 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00002134 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00017500 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1968 | ||||||||
| Expr8654 | |||||||||
| Expr1013555 | |||||||||
| Expr1031338 | |||||||||
| Expr1155097 | |||||||||
| Expr2013041 | |||||||||
| Expr2031273 | |||||||||
| Drives_construct | WBCnstr00013423 | ||||||||
| WBCnstr00036342 | |||||||||
| Construct_product | WBCnstr00013423 | ||||||||
| WBCnstr00036342 | |||||||||
| Antibody | WBAntibody00002492 | ||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (299) | |||||||||
| Interaction (180) | |||||||||
| Map_info | Map | X | Position | 1.72773 | Error | 0.000844 | |||
| Positive | Positive_clone | R07B1 | Person_evidence | WBPerson763 | |||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00005382 | ||||||||
| WBPaper00005432 | |||||||||
| WBPaper00006465 | |||||||||
| WBPaper00011877 | |||||||||
| WBPaper00025192 | |||||||||
| WBPaper00031238 | |||||||||
| WBPaper00032075 | |||||||||
| WBPaper00034766 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00040257 | |||||||||
| WBPaper00044628 | |||||||||
| WBPaper00049828 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00058665 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
