WormBase Tree Display for Gene: WBGene00002239

WBGene00002239 SMap: S_parent: Sequence: F13B9
  Identity: Version: 1
    Name: CGC_name: ksr-1 Person_evidence: WBPerson237
      Sequence_name: F13B9.5
      Molecular_name: F13B9.5
        F13B9.5.1
        CE25854
      Other_name: sur-3
        sar-2
        CELE_F13B9.5 Accession_evidence: NDB BX284606
      Public_name: ksr-1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:27 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ksr
    Allele: WBVar00088368
      WBVar02148892
      WBVar02148891
      WBVar02157606
      WBVar01166508
      WBVar00053521
      WBVar01166509
      WBVar01166510
      WBVar01166511
      WBVar01166512
      WBVar01527048
      WBVar00053526
      WBVar01166513
      WBVar01527049
      WBVar01166514
      WBVar01527050
      WBVar01166515
      WBVar01527051
      WBVar01166516
      WBVar01527052
      WBVar00053531
      WBVar01166517
      WBVar01527053
      WBVar01527054
      WBVar01166518
      WBVar00099275
      WBVar01166519
      WBVar00099276
      WBVar01166520
      WBVar00053536
      WBVar00099277
      WBVar01166521
      WBVar01166522
      WBVar00099279
      WBVar01166523
      WBVar01166524
      WBVar01954485
      WBVar00053541
      WBVar01166525
      WBVar01166526
      WBVar01166527
      WBVar01166528
      WBVar00053546
      WBVar01489232
      WBVar01166529
      WBVar01166530
      WBVar01166531
      WBVar01166532
      WBVar00053551
      WBVar01166533
      WBVar01166534
      WBVar01166535
      WBVar01166536
      WBVar01166537
      WBVar00053556
      WBVar01166538
      WBVar02151453
      WBVar02151823
      WBVar01166539
      WBVar01166540
      WBVar00053561
      WBVar01166541
      WBVar01166542
      WBVar01166543
      WBVar01166544
      WBVar01166545
      WBVar00053566
      WBVar00081179
      WBVar01166546
      WBVar01166547
      WBVar00081182
      WBVar01166548
      WBVar01166549
      WBVar01166550
      WBVar01166551
      WBVar01166552
      WBVar01166553
      WBVar01166554
      WBVar01166555
      WBVar01166556
      WBVar01981054
      WBVar01166557
      WBVar01166558
      WBVar01166559
      WBVar01166560
      WBVar01166561
      WBVar01166562
      WBVar01570920
      WBVar02065089
      WBVar01499781
      WBVar00092066
      WBVar01927600
      WBVar01927601
      WBVar01927602
      WBVar01782328
      WBVar01550661
      WBVar01550662
      WBVar00090499
      WBVar01487307
      WBVar00090505
      WBVar01499642
      WBVar00090508
      WBVar00088311
      WBVar01500012
      WBVar00090511
      WBVar01500013
      WBVar02046618
      WBVar00088317
      WBVar00088321
      WBVar00088326
      WBVar00088327
      WBVar00088328
      WBVar01885082
      WBVar01885083
      WBVar01885084
      WBVar01885085
      WBVar01470083
      WBVar01470084
      WBVar00090281
      WBVar01885086
      WBVar01885087
      WBVar01885088
      WBVar01690178
      WBVar00236481
      WBVar01885089
      WBVar01885090
      WBVar01885091
      WBVar01885092
      WBVar01885093
      WBVar01885094
      WBVar00510326
      WBVar00510327
      WBVar00510328
      WBVar00510329
      WBVar00090546
      WBVar00510330
      WBVar00510331
      WBVar02056509
      WBVar00510332
      WBVar00510333
      WBVar00510334
      WBVar00510335
      WBVar00510336
      WBVar02009052
      WBVar00510337
      WBVar00510338
      WBVar00510339
      WBVar00510340
      WBVar00510341
      WBVar00510342
      WBVar00510343
      WBVar00510344
      WBVar01166496
      WBVar01166497
      WBVar00510345
      WBVar01166498
      WBVar00510346
      WBVar00510347
      WBVar01166499
      WBVar00510348
      WBVar01166500
      WBVar01786873
      WBVar01166501
      WBVar00510349
      WBVar00510350
      WBVar01166502
      WBVar01816185
      WBVar01166503
      WBVar01816186
      WBVar01498960
      WBVar01166504
      WBVar01166505
      WBVar01166506
      WBVar01500067
      WBVar01166507
    Legacy_information: [Kornfeld K] ksr for kinase suppressor of ras. ksr-1 loss-of-function mutations suppress the multivulva phenotype caused by let-60(n1046gf), cause a very low penetrance defect in vulval lineages, and cause about 10% larval lethality with a characteristic rod-like morphology.
      [C.elegansII] pka sur-3, sar-2. Mutations suppress ras mutation,let-60(n1046gf). No phenotype alone in VPC; some larval lethality, Egl and Mig phenotypes. [MT; MH]
    Strain: WBStrain00026498
      WBStrain00026503
      WBStrain00027335
      WBStrain00027336
      WBStrain00027337
      WBStrain00031627
    RNASeq_FPKM (74)
    GO_annotation (25)
    Ortholog (40)
    Paralog (11)
    Structured_description: Concise_description: ksr-1 encodes one of two C. elegans Kinase Suppressor of Ras paralogs; during development, ksr-1 functions singly to control sex myoblast migration and redundantly with ksr-2 to control development of the vulva, excretory system, and male spicules; as ksr-2; ksr-1 doubly mutant animals have severely reduced or absent MPK-1/ERK diphosphorylation levels in somatic tissue, KSR-2 and KSR-1 likely function to positively regulate signaling through the LET-60/Ras pathway; genetic analyses have identified a number of ekl (enhancer of ksr-1 lethality ) mutations that, in combination with a ksr-1 null mutation, result in defects in excretory duct cell fate specification accompanied by larval lethality; the ekl mutations identified gene products that are maternally required for duct cell fate specification and encode proteins likely to be involved in transcriptional and post-transcriptional gene regulation. Paper_evidence: WBPaper00002350
            WBPaper00002351
            WBPaper00005155
            WBPaper00031487
          Curator_confirmed: WBPerson1843
          Date_last_updated: 12 May 2009 00:00:00
      Automated_description: Enables mitogen-activated protein kinase kinase binding activity and protein kinase activity. Involved in several processes, including defense response to Gram-positive bacterium; myoblast migration; and positive regulation of vulval development. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in breast adenocarcinoma. Is an ortholog of human KSR1 (kinase suppressor of ras 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:3458 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6465)
      DOID:1612 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6465)
  Molecular_info: Corresponding_CDS: F13B9.5
    Corresponding_transcript: F13B9.5.1
    Other_sequence (19)
    Associated_feature: WBsf663032
      WBsf1006098
      WBsf1006099
      WBsf1006100
      WBsf1023389
      WBsf1023390
      WBsf236034
  Experimental_info: RNAi_result (11)
    Expr_pattern: Expr1011978
      Expr1031314
      Expr1148436
      Expr2012981
      Expr2031213
    Drives_construct: WBCnstr00036367
    Construct_product: WBCnstr00036367
    Microarray_results (25)
    Expression_cluster (96)
    Interaction (99)
    WBProcess: WBbiopr:00000071
  Map_info: Map: X Position: -0.200671 Error: 0.016778
    Well_ordered
    Positive: Positive_clone: C33E9 Person_evidence: WBPerson341
        F13B9 Person_evidence: WBPerson341
          Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 3616
        4468
  Reference (102)
  Method: Gene