WormBase Tree Display for Gene: WBGene00002231
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WBGene00002231 | SMap | S_parent | Sequence | C02F5 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | knl | ||||||
Allele (38) | |||||||
Strain | WBStrain00037542 | ||||||
WBStrain00054973 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (47) | |||||||
Ortholog (21) | |||||||
Structured_description | Concise_description | knl-1 encodes a novel acidic protein with a coiled-coil region at its C-terminus; KNL-1 is an essential kinetochore component that is required for proper spindle elongation and chromosome separation, and in the kinetochore assembly pathway, plays a key role in linking the initiation of kinetochore formation with the construction of a functional microtubule-binding interface; in the assembly pathway, KNL-1 functions downstream of the DNA-proximal kinetochore components CeCENP-A/HCP-3 and CeCENP-B/HCP-4 and upstream of the outer kinetochore components HIM-10/Nuf2p, NDC-80/HEC1, CeBUB-1, HCP-1, and CeCLASP2/CLS-2; in expression studies in the one-cell embryo, KNL-1 localizes to kinetochores throughout mitosis. | Paper_evidence | WBPaper00004403 | |||
WBPaper00006142 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||
Automated_description | Enables microtubule binding activity. Involved in several processes, including mitotic spindle assembly checkpoint signaling; organelle organization; and positive regulation of protein localization to kinetochore. Located in kinetochore. Part of chromatin and outer kinetochore. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | C02F5.1 | |||||
Corresponding_transcript | C02F5.1.1 | ||||||
Other_sequence | CRC03589_1 | ||||||
CBC01389_1 | |||||||
CR01542 | |||||||
CRC02283_1 | |||||||
CR09829 | |||||||
Associated_feature | WBsf645400 | ||||||
WBsf659244 | |||||||
Experimental_info | RNAi_result (23) | ||||||
Expr_pattern | Expr2744 | ||||||
Expr2745 | |||||||
Expr1022071 | |||||||
Expr1031308 | |||||||
Expr1143556 | |||||||
Expr1200218 | |||||||
Expr2012972 | |||||||
Expr2031204 | |||||||
Drives_construct (19) | |||||||
Construct_product (21) | |||||||
Antibody | WBAntibody00000684 | ||||||
WBAntibody00000685 | |||||||
WBAntibody00001475 | |||||||
Microarray_results (14) | |||||||
Expression_cluster (170) | |||||||
Interaction (93) | |||||||
Map_info | Map | III | Position | -0.353023 | Error | 0.000263 | |
Positive | Positive_clone | C02F5 | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Pseudo_map_position | |||||||
Reference (33) | |||||||
Remark | Sequence connection from [Oegema K, Hyman AA], 02/06/010 krb | ||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |