WormBase Tree Display for Gene: WBGene00002231
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| WBGene00002231 | SMap | S_parent | Sequence | C02F5 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | knl-1 | Person_evidence | WBPerson283 | |||||
| Sequence_name | C02F5.1 | ||||||||
| Molecular_name | C02F5.1 | ||||||||
| C02F5.1.1 | |||||||||
| CE02450 | |||||||||
| Other_name | CELE_C02F5.1 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | knl-1 | ||||||||
| DB_info | Database | AceView | gene | 3J343 | |||||
| WormQTL | gene | WBGene00002231 | |||||||
| WormFlux | gene | WBGene00002231 | |||||||
| NDB | locus_tag | CELE_C02F5.1 | |||||||
| NCBI | gene | 176164 | |||||||
| RefSeq | protein | NM_066410.6 | |||||||
| SwissProt | UniProtAcc | P34278 | |||||||
| UniProt_GCRP | UniProtAcc | P34278 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:27 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | knl | ||||||||
| Allele (38) | |||||||||
| Strain | WBStrain00037542 | ||||||||
| WBStrain00054973 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (47) | |||||||||
| Ortholog (21) | |||||||||
| Structured_description | Concise_description | knl-1 encodes a novel acidic protein with a coiled-coil region at its C-terminus; KNL-1 is an essential kinetochore component that is required for proper spindle elongation and chromosome separation, and in the kinetochore assembly pathway, plays a key role in linking the initiation of kinetochore formation with the construction of a functional microtubule-binding interface; in the assembly pathway, KNL-1 functions downstream of the DNA-proximal kinetochore components CeCENP-A/HCP-3 and CeCENP-B/HCP-4 and upstream of the outer kinetochore components HIM-10/Nuf2p, NDC-80/HEC1, CeBUB-1, HCP-1, and CeCLASP2/CLS-2; in expression studies in the one-cell embryo, KNL-1 localizes to kinetochores throughout mitosis. | Paper_evidence | WBPaper00004403 | |||||
| WBPaper00006142 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables microtubule binding activity. Involved in several processes, including mitotic spindle assembly checkpoint signaling; organelle organization; and positive regulation of protein localization to kinetochore. Located in kinetochore. Part of chromatin and outer kinetochore. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C02F5.1 | |||||||
| Corresponding_transcript | C02F5.1.1 | ||||||||
| Other_sequence | CRC03589_1 | ||||||||
| CBC01389_1 | |||||||||
| CR01542 | |||||||||
| CRC02283_1 | |||||||||
| CR09829 | |||||||||
| Associated_feature | WBsf645400 | ||||||||
| WBsf659244 | |||||||||
| Experimental_info | RNAi_result (23) | ||||||||
| Expr_pattern | Expr2744 | ||||||||
| Expr2745 | |||||||||
| Expr1022071 | |||||||||
| Expr1031308 | |||||||||
| Expr1143556 | |||||||||
| Expr1200218 | |||||||||
| Expr2012972 | |||||||||
| Expr2031204 | |||||||||
| Drives_construct (19) | |||||||||
| Construct_product (21) | |||||||||
| Antibody | WBAntibody00000684 | ||||||||
| WBAntibody00000685 | |||||||||
| WBAntibody00001475 | |||||||||
| Microarray_results (14) | |||||||||
| Expression_cluster (170) | |||||||||
| Interaction (93) | |||||||||
| Map_info | Map | III | Position | -0.353023 | Error | 0.000263 | |||
| Positive | Positive_clone | C02F5 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00006142 | ||||||||
| WBPaper00024319 | |||||||||
| WBPaper00024437 | |||||||||
| WBPaper00024863 | |||||||||
| WBPaper00025028 | |||||||||
| WBPaper00026943 | |||||||||
| WBPaper00027235 | |||||||||
| WBPaper00031316 | |||||||||
| WBPaper00032153 | |||||||||
| WBPaper00032281 | |||||||||
| WBPaper00036019 | |||||||||
| WBPaper00036353 | |||||||||
| WBPaper00037073 | |||||||||
| WBPaper00037839 | |||||||||
| WBPaper00040788 | |||||||||
| WBPaper00043725 | |||||||||
| WBPaper00045114 | |||||||||
| WBPaper00046029 | |||||||||
| WBPaper00046652 | |||||||||
| WBPaper00046983 | |||||||||
| WBPaper00051974 | |||||||||
| WBPaper00052013 | |||||||||
| WBPaper00052034 | |||||||||
| WBPaper00056655 | |||||||||
| WBPaper00056676 | |||||||||
| WBPaper00057778 | |||||||||
| WBPaper00059395 | |||||||||
| WBPaper00060496 | |||||||||
| WBPaper00060640 | |||||||||
| WBPaper00064062 | |||||||||
| WBPaper00065033 | |||||||||
| WBPaper00065685 | |||||||||
| WBPaper00066065 | |||||||||
| Remark | Sequence connection from [Oegema K, Hyman AA], 02/06/010 krb | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
