WormBase Tree Display for Gene: WBGene00002183
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| WBGene00002183 | Evidence | Author_evidence | Mak HY | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | T02G5 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | kat-1 | Person_evidence | WBPerson545 | |||||
| Sequence_name | T02G5.8 | ||||||||
| Molecular_name | T02G5.8 | ||||||||
| T02G5.8.1 | |||||||||
| CE29990 | |||||||||
| Other_name | CELE_T02G5.8 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | kat-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | kat | ||||||||
| Allele (37) | |||||||||
| Strain | WBStrain00040200 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (11) | |||||||||
| Contained_in_operon | CEOP2284 | ||||||||
| Ortholog (36) | |||||||||
| Paralog | WBGene00015125 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00020164 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Inparanoid_8 | |||||||||
| WBGene00009952 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00020166 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00013284 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | kat-1 encodes a predicted 3-ketoacyl-coA thiolase, a conserved enzyme in the mitochondrial fatty acid beta-oxidation pathway; kat-1 acts synergistically with tub-1 and together with the Bardet-Biedl syndrome protein BBS1 ortholog, bbs-1, to regulate lipid accumulation; genetic interaction studies of kat-1 with che-2, osm-5 and daf-6, genes that are required for ciliary structure and intraflagellar transport, indicate that lipid accumulation in C. elegans is dependent on the function of ciliated sensory neurons and their interaction with the environment; kat-1 also acts to delay aging and acts independently of most known longevity pathways but is required for the lifespan extension caused by the overexpression of the protein deacetylase sir-2.1; kat-1 is localized to the mitochondria of intestine and body wall muscle. | Paper_evidence | WBPaper00004637 | |||||
| WBPaper00027085 | |||||||||
| WBPaper00037688 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 11 Jan 2012 00:00:00 | ||||||||
| Automated_description | Predicted to enable acetyl-CoA C-acetyltransferase activity. Predicted to be involved in fatty acid beta-oxidation. Located in mitochondrion. Expressed in body wall musculature. Used to study obesity. Human ortholog(s) of this gene implicated in arteriosclerosis; beta-ketothiolase deficiency; and carbohydrate metabolic disorder. Is an ortholog of human ACAT1 (acetyl-CoA acetyltransferase 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:9970 | Homo sapiens | Paper_evidence | WBPaper00027085 | ||||
| Accession_evidence | OMIM | 601665 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 15 Sep 2017 00:00:00 | ||||||||
| Potential_model | DOID:14723 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:93) | |||||
| DOID:2978 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:93) | ||||||
| DOID:2349 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:93) | ||||||
| Disease_relevance | kat-1 encodes a homolog of the human gene ACAT1, which when mutated leads to alpha-methylacetoaceticaciduria; studies in C. elegans indicate that: kat-1, a predicted thiolase, involved in fatty acid beta-oxidation,interacts with tub-1/tubby which is involved in obesity across species; decreased kat-1 activity appears to be responsible for increased fat accumulation in tub-1/Tubby worms; mutations causing alterations in ciliated neurogenesis mimic the genetic interaction of kat-1 and tub-1, suggesting the involvement of neurohormonal mechanisms in the regulation of lipid accumulation; further, regulation of fat storage may involve a tub-1-mediated endocytic pathway with the Rab-GTPase-activating protein RBG-3 and the small Rab-GTPase, RAB-7. | Homo sapiens | Paper_evidence | WBPaper00031329 | |||||
| WBPaper00038405 | |||||||||
| Accession_evidence | OMIM | 203750 | |||||||
| 601665 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 11 Jan 2012 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000026 | ||||||||
| Molecular_info | Corresponding_CDS | T02G5.8 | |||||||
| Corresponding_transcript | T02G5.8.1 | ||||||||
| Other_sequence (57) | |||||||||
| Associated_feature | WBsf657792 | ||||||||
| WBsf221552 | |||||||||
| WBsf221553 | |||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern (14) | |||||||||
| Drives_construct | WBCnstr00011751 | ||||||||
| WBCnstr00011752 | |||||||||
| WBCnstr00036404 | |||||||||
| Construct_product | WBCnstr00011752 | ||||||||
| WBCnstr00036404 | |||||||||
| Antibody | WBAntibody00000237 | ||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (203) | |||||||||
| Interaction (90) | |||||||||
| Map_info | Map | II | Position | 0.492543 | Error | 0.001914 | |||
| Positive | Positive_clone | T02G5 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4350 | |||||||
| Pseudo_map_position | |||||||||
| Reference (21) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
