WormBase Tree Display for Gene: WBGene00002162
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| WBGene00002162 | SMap | S_parent | Sequence | F42G8 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | isp-1 | |||||||
| Sequence_name | F42G8.12 | ||||||||
| Molecular_name | F42G8.12 | ||||||||
| F42G8.12.1 | |||||||||
| CE17071 | |||||||||
| Other_name | CELE_F42G8.12 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | isp-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | isp | ||||||||
| Allele (37) | |||||||||
| Strain | WBStrain00002958 | ||||||||
| WBStrain00026669 | |||||||||
| WBStrain00026670 | |||||||||
| WBStrain00026672 | |||||||||
| WBStrain00026674 | |||||||||
| WBStrain00035841 | |||||||||
| WBStrain00052465 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (27) | |||||||||
| Ortholog (39) | |||||||||
| Structured_description | Concise_description | isp-1 encodes a Rieske iron sulphur protein (ISP) which is a subunit of the mitochondrial complex III in the mitochondrial membrane; the subunits are highly conserved in all mitochondria and aerobic bacteria; mitochondrial complex III catalyses electron transport from ubiquinol to cytochrome c; isp-1 mutants show low oxygen consumption, a decreased sensitivity to reactive oxygen species and increased lifespan suggesting that mitochondrial electron transport is a key factor affecting life span; isp-1 affects the rates of physiological processes like reproduction and development and also affects behavior. | Paper_evidence | WBPaper00004424 | |||||
| WBPaper00005204 | |||||||||
| WBPaper00005715 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable oxidoreductase activity. Involved in mitochondrial electron transport, ubiquinol to cytochrome c; positive regulation of nematode larval development; and regulation of macromolecule metabolic process. Predicted to be located in mitochondrial inner membrane and respirasome. Predicted to be part of mitochondrial respiratory chain complex III. Expressed in head and tail. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency. Is an ortholog of human UQCRFS1 (ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1) and UQCRFS1P1 (ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 pseudogene 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0111139 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12587) | ||||
| Molecular_info | Corresponding_CDS | F42G8.12 | |||||||
| Corresponding_transcript | F42G8.12.1 | ||||||||
| Other_sequence (140) | |||||||||
| Associated_feature | WBsf651985 | ||||||||
| WBsf668085 | |||||||||
| WBsf230387 | |||||||||
| WBsf230388 | |||||||||
| WBsf230389 | |||||||||
| WBsf230390 | |||||||||
| Experimental_info | RNAi_result (17) | ||||||||
| Expr_pattern | Chronogram1132 | ||||||||
| Expr6052 | |||||||||
| Expr1019404 | |||||||||
| Expr1031265 | |||||||||
| Expr1150992 | |||||||||
| Expr2012870 | |||||||||
| Expr2031104 | |||||||||
| Drives_construct | WBCnstr00003464 | ||||||||
| WBCnstr00036413 | |||||||||
| Construct_product | WBCnstr00036413 | ||||||||
| Regulate_expr_cluster (14) | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (121) | |||||||||
| Interaction (260) | |||||||||
| WBProcess | WBbiopr:00000001 | ||||||||
| Map_info | Map | IV | Position | 3.6224 | Error | 0.001818 | |||
| Positive | Positive_clone | F42G8 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4448 | |||||||
| 4595 | |||||||||
| 4986 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (155) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
