WormBase Tree Display for Gene: WBGene00002056

WBGene00002056 SMap: S_parent: Sequence: CHROMOSOME_X
  Identity: Version: 4
    Name: CGC_name: ifc-2 Person_evidence: WBPerson105
            WBPerson293
            WBPerson260
      Sequence_name: M6.1
      Molecular_name (19)
      Other_name: Cel IF C2 Accession_evidence: X70832
        CelIF c2
        ecp-1 Paper_evidence: WBPaper00057164
        exc-2 Person_evidence: WBPerson260
          Curator_confirmed: WBPerson51134
          Date_last_updated: 07 Aug 2023 16:20:23
        CELE_M6.1 Accession_evidence: NDB BX284606
      Public_name: ifc-2
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:26 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 09 Mar 2021 13:49:30 WBPerson1983 Name_change: Other_name: ecp-1
        3 07 Aug 2023 16:03:35 WBPerson51134 Event: Acquires_merge: WBGene00001363
        4 13 Oct 2023 01:37:05 WBPerson51134 Name_change: CGC_name: ifc-2
                Other_name: exc-2
      Acquires_merge: WBGene00001363
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ifc
    Allele (153)
    Legacy_information: [Buechner M] exc for excretory canal defect. Canals are very short and consist of a series of vacuoles. 100% penetrant. Usually visible by low-power microscopy.
      [C.elegansII] rh90 : excretory canal defect. Canals are very short and consist of a series of vacuoles. Luminal coat partly detached, floats in canal.100% penetrant.Usually visible by low-power microscopy. Affects tail spike ??? OA1: rh105. [NJ]
    Strain: WBStrain00002850
      WBStrain00028840
      WBStrain00047374
    RNASeq_FPKM (74)
    GO_annotation (17)
    Ortholog: WBGene00029993 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00130434 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00193709 Caenorhabditis brenneri From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00060256 Caenorhabditis remanei From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      CBOVI.g3502 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP26.g6531 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g13415 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g20745 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g11489 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP31.g6186 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g16578 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g18686 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g9802 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g4233 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cni-ifc-2 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold629.g15649 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00191.g6675 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_03226 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_022184 Caenorhabditis remanei From_analysis: WormBase-Compara
      Sp34_X0019000 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrX_pilon.g18308 Caenorhabditis elegans From_analysis: WormBase-Compara
      ZFIN:ZDB-GENE-991008-6 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
      ZFIN:ZDB-GENE-030131-7018 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
      ZFIN:ZDB-GENE-030131-8568 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
      ZFIN:ZDB-GENE-061026-4 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
      ZFIN:ZDB-GENE-991110-23 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
      HGNC:6412 Homo sapiens From_analysis: EnsEMBL-Compara
            OMA
      HGNC:6439 Homo sapiens From_analysis: EnsEMBL-Compara
            OMA
      HGNC:6440 Homo sapiens From_analysis: EnsEMBL-Compara
            OMA
      HGNC:6442 Homo sapiens From_analysis: EnsEMBL-Compara
            OMA
      HGNC:6443 Homo sapiens From_analysis: EnsEMBL-Compara
            OMA
      HGNC:6444 Homo sapiens From_analysis: EnsEMBL-Compara
            OMA
      HGNC:6413 Homo sapiens From_analysis: EnsEMBL-Compara
            OMA
      HGNC:24431 Homo sapiens From_analysis: EnsEMBL-Compara
            OMA
      HGNC:24430 Homo sapiens From_analysis: EnsEMBL-Compara
            OMA
      HGNC:28932 Homo sapiens From_analysis: EnsEMBL-Compara
            OMA
      HGNC:20406 Homo sapiens From_analysis: EnsEMBL-Compara
            OMA
      HGNC:20411 Homo sapiens From_analysis: EnsEMBL-Compara
            OMA
      MGI:96685 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
      MGI:96690 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
      MGI:96698 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
      MGI:96700 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
      MGI:1100845 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
      MGI:1333768 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
      MGI:1924305 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
      MGI:96702 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
      MGI:3045312 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
      MGI:3646939 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
      RGD:2911 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
      RGD:3159 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
      RGD:3160 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
      RGD:1359576 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
      RGD:1359597 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
      RGD:1359664 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
      RGD:1359402 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
      RGD:1359272 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
      RGD:1565564 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
      RGD:727894 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
      RGD:1303297 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
      RGD:1303078 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
      RGD:1588056 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
    Paralog (12)
    Structured_description: Concise_description: ifc-2 encodes three isoforms of an intermediate filament protein dispensable for viability but required for normal movement, growth rate, body size, body shape, and cuticle strength; IFC-2 is present in the cytoplasm of intestinal cells, and at the desmosomes of intestinal and pharyngeal cells. Paper_evidence: WBPaper00001981
            WBPaper00004761
            WBPaper00005492
            WBPaper00006137
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to be a structural constituent of cytoskeleton. Involved in post-embryonic digestive tract morphogenesis. Located in cytoplasm and desmosome. Expressed in several structures, including excretory canal; pharyngeal-intestinal valve; pharynx; rectal valve cell; and uterus. Human ortholog(s) of this gene implicated in several diseases, including Dowling-Degos disease; ichthyosis (multiple); and palmoplantar keratosis (multiple). Is an ortholog of several human genes including KRT1 (keratin 1); KRT2 (keratin 2); and KRT3 (keratin 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (14)
  Molecular_info: Corresponding_CDS: M6.1a
      M6.1b
      M6.1c
      M6.1d
      M6.1e
      M6.1f
    Corresponding_CDS_history: M6.1a:wp272
      M6.1b:wp272
      M6.1c:wp272
    Corresponding_transcript: M6.1a.1
      M6.1a.2
      M6.1b.1
      M6.1c.1
      M6.1d.1
      M6.1e.1
      M6.1f.1
    Other_sequence: CR07924
      FD516689.1
      CBC09732_1
      CJC02211_1
      CBC03886_1
      CSC00034_1
      CRC05750_1
    Associated_feature (13)
  Experimental_info: RNAi_result (27)
    Expr_pattern (17)
    Drives_construct: WBCnstr00003372
      WBCnstr00036488
      WBCnstr00042147
      WBCnstr00042148
      WBCnstr00042149
    Construct_product: WBCnstr00036488
      WBCnstr00042019
      WBCnstr00042020
      WBCnstr00042147
    Antibody: WBAntibody00000563
      WBAntibody00002893
      WBAntibody00002913
    Microarray_results (39)
    Expression_cluster (285)
    Interaction (77)
  Map_info: Map: X Position: -19.5186 Error: 0.005743
    Positive: Positive_clone: M6 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4971
    Pseudo_map_position
  Reference (41)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene