WormBase Tree Display for Gene: WBGene00002031
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| WBGene00002031 | SMap | S_parent | Sequence | Y34B4A | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | hst-6 | Person_evidence | WBPerson1831 | |||||
| Sequence_name | Y34B4A.3 | ||||||||
| Molecular_name | Y34B4A.3 | ||||||||
| Y34B4A.3.1 | |||||||||
| CE32011 | |||||||||
| Other_name | Y34B4A.e | Curator_confirmed | WBPerson1983 | ||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| CELE_Y34B4A.3 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | hst-6 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | hst | ||||||||
| Allele (56) | |||||||||
| Strain | WBStrain00029287 | ||||||||
| WBStrain00029319 | |||||||||
| WBStrain00029330 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (11) | |||||||||
| Ortholog (46) | |||||||||
| Structured_description | Concise_description | hst-6 encodes the C. elegans ortholog of the heparan sulfate modifying enzyme heparan 6O-sulfotransferase; by homology, HST-6 is predicted to function in heparan sulfate biosynthesis by catalyzing the chain-modifying sulfation of the C6 hydroxyl group of the glucosamine subunits; during development, hst-6 activity is required for normal body size and nervous system development; an hst-6::gfp transcriptional reporter fusion is expressed beginning at early embryonic stages and continuing through adulthood; expression in embryos is nearly ubiquitous with later expression primarily restricted to neuronal tissues. | Paper_evidence | WBPaper00006471 | |||||
| WBPaper00029002 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 26 Oct 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable heparan sulfate 6-O-sulfotransferase activity. Involved in heparan sulfate proteoglycan biosynthetic process, enzymatic modification and regulation of growth. Predicted to be located in membrane. Expressed in AIBL; AIBR; RIML; RIMR; and neurons. Human ortholog(s) of this gene implicated in Paganini-Miozzo syndrome and hypogonadotropic hypogonadism 15 with or without anosmia. Is an ortholog of human HS6ST1 (heparan sulfate 6-O-sulfotransferase 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0111843 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:19133) | ||||
| DOID:0090075 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5201) | ||||||
| Molecular_info | Corresponding_CDS | Y34B4A.3 | |||||||
| Corresponding_CDS_history | Y34B4A.3:wp86 | ||||||||
| Corresponding_transcript | Y34B4A.3.1 | ||||||||
| Other_sequence (28) | |||||||||
| Associated_feature | WBsf648093 | ||||||||
| WBsf662771 | |||||||||
| WBsf1005223 | |||||||||
| WBsf235701 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00020191 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00055817 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr2901 | ||||||||
| Expr12886 | |||||||||
| Expr1014721 | |||||||||
| Expr1031186 | |||||||||
| Expr1159347 | |||||||||
| Expr2012637 | |||||||||
| Expr2030873 | |||||||||
| Drives_construct | WBCnstr00011014 | ||||||||
| WBCnstr00016152 | |||||||||
| WBCnstr00036509 | |||||||||
| Construct_product | WBCnstr00005444 | ||||||||
| WBCnstr00005695 | |||||||||
| WBCnstr00005696 | |||||||||
| WBCnstr00005697 | |||||||||
| WBCnstr00005699 | |||||||||
| WBCnstr00005700 | |||||||||
| WBCnstr00005701 | |||||||||
| WBCnstr00005702 | |||||||||
| WBCnstr00005703 | |||||||||
| WBCnstr00036509 | |||||||||
| Microarray_results (17) | |||||||||
| Expression_cluster (104) | |||||||||
| Interaction (12) | |||||||||
| Anatomy_function | WBbtf0285 | ||||||||
| Map_info | Map | X | Position | -5.86683 | Error | 0.040424 | |||
| Positive | Positive_clone | Y34B4A | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4422 | |||||||
| 4502 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (29) | |||||||||
| Remark | Sequence connection from [Turnbull J, Kinnunen T]. krb 13/11/01 | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
