hsp-25 encodes a member of the small heat shock family of proteins; HSP-25 is expressed throughout development and in vitro, exhibits chaperone activity; HSP-25 localizes to: 1) dense bodies and M lines in body wall muscle, 2) the lining of the pharynx, and 3) to cell-cell junctions in the spermathecal wall; consistent with a role in myofibril organization, HSP-25 binds vinculin and alpha-actinin in vitro.
Predicted to enable unfolded protein binding activity. Predicted to be involved in protein refolding and response to heat. Located in M band and striated muscle dense body. Expressed in body wall musculature; gonad; pharynx; and spermatheca. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2L and distal hereditary motor neuronopathy type 2A. Is an ortholog of human HSPB8 (heat shock protein family B (small) member 8).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.