WormBase Tree Display for Gene: WBGene00002018
expand all nodes | collapse all nodes | view schema
| WBGene00002018 | SMap | S_parent | Sequence | Y46H3A | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | hsp-16.41 | Person_evidence | WBPerson36 | |||||
| Sequence_name | Y46H3A.2 | ||||||||
| Molecular_name | Y46H3A.2 | ||||||||
| Y46H3A.2.1 | |||||||||
| CE22003 | |||||||||
| Other_name | hsp-16 | ||||||||
| CELE_Y46H3A.2 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | hsp-16.41 | ||||||||
| DB_info | Database | AceView | gene | 5C283 | |||||
| WormQTL | gene | WBGene00002018 | |||||||
| WormFlux | gene | WBGene00002018 | |||||||
| NDB | locus_tag | CELE_Y46H3A.2 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00002018|UniProtKB=P06581 | |||||||
| family | PTHR45640 | ||||||||
| NCBI | gene | 178660 | |||||||
| RefSeq | protein | NM_182316.5 | |||||||
| SwissProt | UniProtAcc | P06581 | |||||||
| UniProt_GCRP | UniProtAcc | P06581 | |||||||
| OMIM | gene | 123580 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | hsp | ||||||||
| Allele (21) | |||||||||
| Strain (15) | |||||||||
| In_cluster | HSP16B | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (11) | |||||||||
| Ortholog (91) | |||||||||
| Paralog (17) | |||||||||
| Structured_description | Concise_description | hsp-16.41 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins; an hsp-16.41 reporter fusion, expressed broadly but strongest in intestine and pharynx, is induced in response to heat shock or other environmental stresses; expression is detectable in somatic tissues in post-gastrulation embryos, all larval stages, and in adults; HSP-16.41 is likely to function as a passive ligand temporarily preventing unfolded proteins from aggregating. | Paper_evidence | WBPaper00001187 | |||||
| WBPaper00001497 | |||||||||
| WBPaper00002665 | |||||||||
| WBPaper00004424 | |||||||||
| WBPaper00013029 | |||||||||
| WBPaper00013239 | |||||||||
| WBPaper00013280 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 05 Nov 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable unfolded protein binding activity. Involved in defense response to Gram-negative bacterium and response to heat. Predicted to be located in cytoplasm and nucleus. Expressed in several structures, including alimentary muscle; coelomocyte; intestine; neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in cataract 9 multiple types. Is an ortholog of human CRYAA (crystallin alpha A). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0110266 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2388) | ||||
| Disease_relevance | C. elegans is an effective model system to study heat-related pathologies like heat stroke; in elegans, the heat-shock transcription factor, after activation, induces the expression of other small heat shock proteins (sHSP); HSP-16.1 has a protective effect against heat-induced necrosis; HSP-16.1 localizes to the golgi and functions together with the PMR-1/PMR1 Ca2+ and Mn2+ transporting ATPase, and NUCB-1/Nucleobindin1, a golgi-located calcium-buffering protein, to maintain calcium homeostasis, under heat stroke; overexpresiion of pmr-1/PMR1 is sufficient to promote survival after heat stroke, bypassing both HSF-1 and HSP-16.1, indicating that PMR-1/PMR1 functions downstream of both these genes; also, the sHSPs, HSP-16.1, HSP-16.41 and DNJ-19 are required for an acquired tolerance to heat stroke. | Homo sapiens | Paper_evidence | WBPaper00041564 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 29 May 2013 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | Y46H3A.2 | |||||||
| Corresponding_transcript | Y46H3A.2.1 | ||||||||
| Other_sequence (61) | |||||||||
| Associated_feature | WBsf646680 | ||||||||
| WBsf646681 | |||||||||
| WBsf919559 | |||||||||
| WBsf919560 | |||||||||
| WBsf919561 | |||||||||
| WBsf919562 | |||||||||
| WBsf231437 | |||||||||
| WBsf231438 | |||||||||
| WBsf231439 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00027603 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00056699 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00106383 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00076794 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00070131 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00020673 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00000045 | ||||||||
| WBCnstr00000161 | |||||||||
| WBCnstr00000196 | |||||||||
| WBCnstr00000197 | |||||||||
| WBCnstr00000198 | |||||||||
| WBCnstr00000200 | |||||||||
| WBCnstr00000201 | |||||||||
| WBCnstr00000202 | |||||||||
| WBCnstr00000203 | |||||||||
| WBCnstr00000312 | |||||||||
| WBCnstr00000341 | |||||||||
| WBCnstr00000368 | |||||||||
| WBCnstr00000451 | |||||||||
| WBCnstr00000452 | |||||||||
| WBCnstr00000524 | |||||||||
| WBCnstr00000612 | |||||||||
| WBCnstr00000634 | |||||||||
| WBCnstr00000788 | |||||||||
| WBCnstr00000790 | |||||||||
| WBCnstr00000871 | |||||||||
| WBCnstr00000939 | |||||||||
| WBCnstr00000940 | |||||||||
| WBCnstr00000957 | |||||||||
| WBCnstr00001030 | |||||||||
| WBCnstr00001233 | |||||||||
| WBCnstr00001399 | |||||||||
| WBCnstr00001407 | |||||||||
| WBCnstr00001677 | |||||||||
| WBCnstr00001705 | |||||||||
| WBCnstr00001706 | |||||||||
| WBCnstr00001728 | |||||||||
| WBCnstr00001729 | |||||||||
| WBCnstr00001875 | |||||||||
| WBCnstr00001880 | |||||||||
| WBCnstr00001881 | |||||||||
| WBCnstr00001998 | |||||||||
| WBCnstr00004601 | |||||||||
| WBCnstr00004638 | |||||||||
| WBCnstr00004641 | |||||||||
| WBCnstr00004643 | |||||||||
| WBCnstr00004651 | |||||||||
| WBCnstr00004652 | |||||||||
| WBCnstr00004695 | |||||||||
| WBCnstr00004719 | |||||||||
| WBCnstr00004721 | |||||||||
| WBCnstr00004895 | |||||||||
| WBCnstr00005018 | |||||||||
| WBCnstr00005019 | |||||||||
| WBCnstr00005020 | |||||||||
| WBCnstr00005021 | |||||||||
| WBCnstr00005022 | |||||||||
| WBCnstr00005040 | |||||||||
| WBCnstr00005100 | |||||||||
| WBCnstr00005113 | |||||||||
| WBCnstr00005162 | |||||||||
| WBCnstr00005194 | |||||||||
| WBCnstr00005635 | |||||||||
| WBCnstr00005636 | |||||||||
| WBCnstr00005637 | |||||||||
| WBCnstr00005638 | |||||||||
| WBCnstr00005639 | |||||||||
| WBCnstr00005733 | |||||||||
| WBCnstr00005734 | |||||||||
| WBCnstr00005883 | |||||||||
| WBCnstr00006064 | |||||||||
| WBCnstr00006065 | |||||||||
| WBCnstr00006066 | |||||||||
| WBCnstr00006067 | |||||||||
| WBCnstr00006069 | |||||||||
| WBCnstr00006306 | |||||||||
| WBCnstr00006307 | |||||||||
| WBCnstr00006308 | |||||||||
| WBCnstr00006713 | |||||||||
| WBCnstr00006714 | |||||||||
| WBCnstr00006722 | |||||||||
| WBCnstr00006803 | |||||||||
| WBCnstr00006804 | |||||||||
| WBCnstr00006805 | |||||||||
| WBCnstr00006806 | |||||||||
| WBCnstr00006825 | |||||||||
| WBCnstr00006828 | |||||||||
| WBCnstr00006829 | |||||||||
| WBCnstr00006830 | |||||||||
| WBCnstr00006929 | |||||||||
| WBCnstr00006930 | |||||||||
| WBCnstr00006986 | |||||||||
| WBCnstr00006990 | |||||||||
| WBCnstr00006991 | |||||||||
| WBCnstr00006992 | |||||||||
| WBCnstr00006993 | |||||||||
| WBCnstr00006996 | |||||||||
| WBCnstr00006998 | |||||||||
| WBCnstr00007323 | |||||||||
| WBCnstr00007542 | |||||||||
| WBCnstr00007565 | |||||||||
| WBCnstr00007566 | |||||||||
| WBCnstr00007567 | |||||||||
| WBCnstr00007910 | |||||||||
| WBCnstr00007911 | |||||||||
| WBCnstr00007912 | |||||||||
| WBCnstr00008293 | |||||||||
| WBCnstr00008325 | |||||||||
| WBCnstr00008660 | |||||||||
| WBCnstr00008661 | |||||||||
| WBCnstr00008697 | |||||||||
| WBCnstr00008774 | |||||||||
| WBCnstr00008776 | |||||||||
| WBCnstr00008777 | |||||||||
| WBCnstr00009222 | |||||||||
| WBCnstr00009428 | |||||||||
| WBCnstr00009433 | |||||||||
| WBCnstr00009434 | |||||||||
| WBCnstr00009435 | |||||||||
| WBCnstr00009670 | |||||||||
| WBCnstr00009671 | |||||||||
| WBCnstr00009693 | |||||||||
| WBCnstr00009718 | |||||||||
| WBCnstr00009948 | |||||||||
| WBCnstr00009950 | |||||||||
| WBCnstr00010254 | |||||||||
| WBCnstr00010255 | |||||||||
| WBCnstr00010947 | |||||||||
| WBCnstr00014409 | |||||||||
| WBCnstr00014693 | |||||||||
| WBCnstr00014720 | |||||||||
| WBCnstr00014726 | |||||||||
| WBCnstr00014785 | |||||||||
| WBCnstr00014786 | |||||||||
| WBCnstr00014787 | |||||||||
| WBCnstr00014788 | |||||||||
| WBCnstr00014789 | |||||||||
| WBCnstr00014826 | |||||||||
| WBCnstr00014827 | |||||||||
| WBCnstr00015526 | |||||||||
| WBCnstr00015548 | |||||||||
| WBCnstr00017083 | |||||||||
| WBCnstr00017122 | |||||||||
| WBCnstr00017959 | |||||||||
| WBCnstr00018332 | |||||||||
| WBCnstr00018333 | |||||||||
| WBCnstr00018334 | |||||||||
| WBCnstr00018675 | |||||||||
| WBCnstr00018929 | |||||||||
| WBCnstr00018930 | |||||||||
| WBCnstr00018931 | |||||||||
| WBCnstr00019177 | |||||||||
| WBCnstr00019202 | |||||||||
| WBCnstr00019615 | |||||||||
| WBCnstr00019669 | |||||||||
| WBCnstr00019670 | |||||||||
| WBCnstr00019789 | |||||||||
| WBCnstr00020122 | |||||||||
| WBCnstr00020982 | |||||||||
| WBCnstr00021185 | |||||||||
| WBCnstr00021638 | |||||||||
| WBCnstr00022804 | |||||||||
| WBCnstr00022879 | |||||||||
| WBCnstr00022880 | |||||||||
| WBCnstr00036518 | |||||||||
| WBCnstr00038256 | |||||||||
| WBCnstr00038257 | |||||||||
| WBCnstr00038258 | |||||||||
| WBCnstr00038259 | |||||||||
| WBCnstr00038363 | |||||||||
| WBCnstr00039046 | |||||||||
| WBCnstr00041723 | |||||||||
| WBCnstr00041727 | |||||||||
| WBCnstr00042123 | |||||||||
| WBCnstr00042124 | |||||||||
| WBCnstr00042125 | |||||||||
| WBCnstr00042209 | |||||||||
| WBCnstr00042652 | |||||||||
| WBCnstr00042785 | |||||||||
| WBCnstr00042802 | |||||||||
| WBCnstr00042803 | |||||||||
| WBCnstr00042948 | |||||||||
| Construct_product (5) | |||||||||
| Antibody | WBAntibody00000051 | ||||||||
| WBAntibody00001859 | |||||||||
| Microarray_results (17) | |||||||||
| Expression_cluster (413) | |||||||||
| Interaction (45) | |||||||||
| Map_info | Map | V | Position | -17.4232 | Error | 0.07866 | |||
| Positive | Positive_clone | Y46H3A | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4418 | |||||||
| Pseudo_map_position | |||||||||
| Reference (69) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
