WormBase Tree Display for Gene: WBGene00002015
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WBGene00002015 | SMap | S_parent | Sequence | T27E4 | ||
---|---|---|---|---|---|---|
Identity (6) | ||||||
Gene_info | Biotype | SO:0001217 | ||||
Gene_class | hsp | |||||
Allele | WBVar01499903 | |||||
WBVar01500129 | ||||||
WBVar00091863 | ||||||
WBVar01499419 | ||||||
WBVar01499420 | ||||||
WBVar01499056 | ||||||
WBVar01499249 | ||||||
WBVar01499316 | ||||||
Strain | WBStrain00004819 | |||||
WBStrain00004820 | ||||||
WBStrain00030548 | ||||||
WBStrain00030720 | ||||||
WBStrain00030838 | ||||||
In_cluster | HSP16A | |||||
RNASeq_FPKM (74) | ||||||
GO_annotation | 00044149 | |||||
00044150 | ||||||
00044151 | ||||||
00044152 | ||||||
00044153 | ||||||
00044154 | ||||||
00105765 | ||||||
00105800 | ||||||
00106135 | ||||||
00106136 | ||||||
Ortholog (91) | ||||||
Paralog (17) | ||||||
Structured_description | Concise_description | hsp-16.1 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins, and that is identical to the protein encoded by hsp-16.11; an hsp-16.1 reporter fusion, expressed broadly but most strongly in muscle and hypodermis, is induced solely in response to heat shock or other environmental stresses; expression is detectable in somatic tissues in post-gastrulation embryos, all larval stages, and in adults; HSP-16.1 is likely to function as a passive ligand temporarily preventing unfolded proteins from aggregating. | Paper_evidence | WBPaper00001187 | ||
WBPaper00001497 | ||||||
WBPaper00002665 | ||||||
WBPaper00004424 | ||||||
WBPaper00013029 | ||||||
WBPaper00013239 | ||||||
WBPaper00013280 | ||||||
Curator_confirmed | WBPerson1843 | |||||
Date_last_updated | 05 Nov 2004 00:00:00 | |||||
Automated_description | Predicted to enable unfolded protein binding activity. Involved in defense response to Gram-negative bacterium and response to heat. Located in Golgi medial cisterna. Expressed in several structures, including coelomocyte; enteric muscle; intestine; pharynx; and ventral nerve cord. | Paper_evidence | WBPaper00065943 | |||
Curator_confirmed | WBPerson324 | |||||
WBPerson37462 | ||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | |||||
Date_last_updated | 29 Nov 2023 00:00:00 | |||||
Disease_info | Disease_relevance | C. elegans is an effective model system to study heat-related pathologies like heat stroke; in elegans, a small heat shock protein (sHSP), HSP-16.1 has a protective effect against heat-induced necrosis; HSP-16.1 localizes to the golgi and functions together with the PMR-1/PMR1 Ca2+ and Mn2+ transporting ATPase, and NUCB-1/Nucleobindin1, a golgi-located calcium-buffering protein, to maintain calcium homeostasis, under heat stroke; overexpresiion of pmr-1/PMR1 is sufficient to promote survival after heat stroke, bypassing both HSF-1 and HSP-16.1, indicating that PMR-1/PMR1 functions downstream of both these genes. | Homo sapiens | Paper_evidence | WBPaper00041564 | |
Curator_confirmed | WBPerson324 | |||||
Date_last_updated | 29 May 2013 00:00:00 | |||||
Molecular_info | Corresponding_CDS | T27E4.8 | ||||
Corresponding_transcript | T27E4.8.1 | |||||
Other_sequence (60) | ||||||
Associated_feature | WBsf977958 | Paper_evidence | WBPaper00000918 | |||
WBsf977959 | Paper_evidence | WBPaper00000918 | ||||
WBsf977962 | ||||||
WBsf1000813 | ||||||
WBsf234177 | ||||||
WBsf234178 | ||||||
Experimental_info | RNAi_result (21) | |||||
Expr_pattern | Expr1381 | |||||
Expr1384 | ||||||
Expr10597 | ||||||
Expr11025 | ||||||
Expr15516 | ||||||
Expr1157862 | ||||||
Expr2012617 | ||||||
Expr2030853 | ||||||
Drives_construct (37) | ||||||
Construct_product | WBCnstr00010254 | |||||
WBCnstr00017024 | ||||||
WBCnstr00019264 | ||||||
WBCnstr00036521 | ||||||
WBCnstr00042207 | ||||||
Antibody | WBAntibody00000049 | |||||
WBAntibody00001859 | ||||||
Microarray_results (24) | ||||||
Expression_cluster (245) | ||||||
Interaction (92) | ||||||
WBProcess | WBbiopr:00000050 | |||||
Map_info (4) | ||||||
Reference (121) | ||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||
Method | Gene |