WormBase Tree Display for Gene: WBGene00002015
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WBGene00002015 | SMap | S_parent | Sequence | T27E4 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | hsp | ||||||
Allele | WBVar01499903 | ||||||
WBVar01500129 | |||||||
WBVar00091863 | |||||||
WBVar01499419 | |||||||
WBVar01499420 | |||||||
WBVar01499056 | |||||||
WBVar01499249 | |||||||
WBVar01499316 | |||||||
Strain | WBStrain00004819 | ||||||
WBStrain00004820 | |||||||
WBStrain00030548 | |||||||
WBStrain00030720 | |||||||
WBStrain00030838 | |||||||
In_cluster | HSP16A | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation | 00044149 | ||||||
00044150 | |||||||
00044151 | |||||||
00044152 | |||||||
00044153 | |||||||
00044154 | |||||||
00105765 | |||||||
00105800 | |||||||
00106135 | |||||||
00106136 | |||||||
Ortholog (91) | |||||||
Paralog (17) | |||||||
Structured_description | Concise_description | hsp-16.1 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins, and that is identical to the protein encoded by hsp-16.11; an hsp-16.1 reporter fusion, expressed broadly but most strongly in muscle and hypodermis, is induced solely in response to heat shock or other environmental stresses; expression is detectable in somatic tissues in post-gastrulation embryos, all larval stages, and in adults; HSP-16.1 is likely to function as a passive ligand temporarily preventing unfolded proteins from aggregating. | Paper_evidence | WBPaper00001187 | |||
WBPaper00001497 | |||||||
WBPaper00002665 | |||||||
WBPaper00004424 | |||||||
WBPaper00013029 | |||||||
WBPaper00013239 | |||||||
WBPaper00013280 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 05 Nov 2004 00:00:00 | ||||||
Automated_description | Predicted to enable unfolded protein binding activity. Involved in defense response to Gram-negative bacterium and response to heat. Located in Golgi medial cisterna. Expressed in several structures, including coelomocyte; enteric muscle; intestine; pharynx; and ventral nerve cord. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Disease_relevance | C. elegans is an effective model system to study heat-related pathologies like heat stroke; in elegans, a small heat shock protein (sHSP), HSP-16.1 has a protective effect against heat-induced necrosis; HSP-16.1 localizes to the golgi and functions together with the PMR-1/PMR1 Ca2+ and Mn2+ transporting ATPase, and NUCB-1/Nucleobindin1, a golgi-located calcium-buffering protein, to maintain calcium homeostasis, under heat stroke; overexpresiion of pmr-1/PMR1 is sufficient to promote survival after heat stroke, bypassing both HSF-1 and HSP-16.1, indicating that PMR-1/PMR1 functions downstream of both these genes. | Homo sapiens | Paper_evidence | WBPaper00041564 | ||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 29 May 2013 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | T27E4.8 | |||||
Corresponding_transcript | T27E4.8.1 | ||||||
Other_sequence (60) | |||||||
Associated_feature | WBsf977958 | Paper_evidence | WBPaper00000918 | ||||
WBsf977959 | Paper_evidence | WBPaper00000918 | |||||
WBsf977962 | |||||||
WBsf1000813 | |||||||
WBsf234177 | |||||||
WBsf234178 | |||||||
Experimental_info | RNAi_result (21) | ||||||
Expr_pattern | Expr1381 | ||||||
Expr1384 | |||||||
Expr10597 | |||||||
Expr11025 | |||||||
Expr15516 | |||||||
Expr1157862 | |||||||
Expr2012617 | |||||||
Expr2030853 | |||||||
Drives_construct (37) | |||||||
Construct_product | WBCnstr00010254 | ||||||
WBCnstr00017024 | |||||||
WBCnstr00019264 | |||||||
WBCnstr00036521 | |||||||
WBCnstr00042207 | |||||||
Antibody | WBAntibody00000049 | ||||||
WBAntibody00001859 | |||||||
Microarray_results | SMD_T27E4.8 | ||||||
189087_s_at | |||||||
A_12_P110679 | |||||||
Aff_T27E4.2 | |||||||
GPL13394_WBGene00002017 | |||||||
GPL13914_T27E4.2 | |||||||
GPL14144_T27E4.2_171-230_0.514_60_C | |||||||
GPL14144_T27E4.2_262-321_0.911_1_A | |||||||
GPL14144_T27E4.2_378-437_0.692_33_B | |||||||
GPL19516_CGZ0037146 | |||||||
GPL19516_CGZ0037153 | |||||||
GPL21109_T27E4.2 | |||||||
GPL3518_CE14249 | |||||||
GPL8304_CE_WBGene00002015_A | |||||||
GPL8304_CE_WBGene00002015_C | |||||||
GPL8304_CE_WBGene00002017_A | |||||||
GPL8673_T27E4_2P00061 | |||||||
GPL8673_T27E4_2P00134 | |||||||
GPL8673_T27E4_2P00361 | |||||||
GPL8673_T27E4_8P00061 | |||||||
GPL8673_T27E4_8P00134 | |||||||
GPL8673_T27E4_8P00361 | |||||||
GPL9450_T27E4.2_92 | |||||||
GPL9450_T27E4.8_92 | |||||||
Expression_cluster (245) | |||||||
Interaction (92) | |||||||
WBProcess | WBbiopr:00000050 | ||||||
Map_info | Map | V | Position | 1.9236 | Error | 0.000891 | |
Positive | Positive_clone | T27E4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point | 4419 | |||||
5342 | |||||||
Pseudo_map_position | |||||||
Reference (121) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |