WormBase Tree Display for Gene: WBGene00002015

WBGene00002015 SMap: S_parent: Sequence: T27E4
  Identity: Version: 1
    Name: CGC_name: hsp-16.1 Person_evidence: WBPerson36
      Sequence_name: T27E4.8
      Molecular_name: T27E4.8
        T27E4.8.1
        CE14249
      Other_name: hsp-16
        CELE_T27E4.8 Accession_evidence: NDB BX284605
      Public_name: hsp-16.1
    DB_info: Database (9)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:26 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: hsp
    Allele: WBVar01499903
      WBVar01500129
      WBVar00091863
      WBVar01499419
      WBVar01499420
      WBVar01499056
      WBVar01499249
      WBVar01499316
    Strain: WBStrain00004819
      WBStrain00004820
      WBStrain00030548
      WBStrain00030720
      WBStrain00030838
    In_cluster: HSP16A
    RNASeq_FPKM (74)
    GO_annotation: 00044149
      00044150
      00044151
      00044152
      00044153
      00044154
      00105765
      00105800
      00106135
      00106136
    Ortholog (91)
    Paralog (17)
    Structured_description: Concise_description: hsp-16.1 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins, and that is identical to the protein encoded by hsp-16.11; an hsp-16.1 reporter fusion, expressed broadly but most strongly in muscle and hypodermis, is induced solely in response to heat shock or other environmental stresses; expression is detectable in somatic tissues in post-gastrulation embryos, all larval stages, and in adults; HSP-16.1 is likely to function as a passive ligand temporarily preventing unfolded proteins from aggregating. Paper_evidence: WBPaper00001187
            WBPaper00001497
            WBPaper00002665
            WBPaper00004424
            WBPaper00013029
            WBPaper00013239
            WBPaper00013280
          Curator_confirmed: WBPerson1843
          Date_last_updated: 05 Nov 2004 00:00:00
      Automated_description: Predicted to enable unfolded protein binding activity. Involved in defense response to Gram-negative bacterium and response to heat. Located in Golgi medial cisterna. Expressed in several structures, including coelomocyte; enteric muscle; intestine; pharynx; and ventral nerve cord. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Disease_relevance: C. elegans is an effective model system to study heat-related pathologies like heat stroke; in elegans, a small heat shock protein (sHSP), HSP-16.1 has a protective effect against heat-induced necrosis; HSP-16.1 localizes to the golgi and functions together with the PMR-1/PMR1 Ca2+ and Mn2+ transporting ATPase, and NUCB-1/Nucleobindin1, a golgi-located calcium-buffering protein, to maintain calcium homeostasis, under heat stroke; overexpresiion of pmr-1/PMR1 is sufficient to promote survival after heat stroke, bypassing both HSF-1 and HSP-16.1, indicating that PMR-1/PMR1 functions downstream of both these genes. Homo sapiens Paper_evidence: WBPaper00041564
          Curator_confirmed: WBPerson324
          Date_last_updated: 29 May 2013 00:00:00
  Molecular_info: Corresponding_CDS: T27E4.8
    Corresponding_transcript: T27E4.8.1
    Other_sequence (60)
    Associated_feature: WBsf977958 Paper_evidence: WBPaper00000918
      WBsf977959 Paper_evidence: WBPaper00000918
      WBsf977962
      WBsf1000813
      WBsf234177
      WBsf234178
  Experimental_info: RNAi_result (21)
    Expr_pattern: Expr1381
      Expr1384
      Expr10597
      Expr11025
      Expr15516
      Expr1157862
      Expr2012617
      Expr2030853
    Drives_construct (37)
    Construct_product: WBCnstr00010254
      WBCnstr00017024
      WBCnstr00019264
      WBCnstr00036521
      WBCnstr00042207
    Antibody: WBAntibody00000049
      WBAntibody00001859
    Microarray_results (24)
    Expression_cluster (245)
    Interaction (92)
    WBProcess: WBbiopr:00000050
  Map_info: Map: V Position: 1.9236 Error: 0.000891
    Positive: Positive_clone: T27E4 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4419
        5342
    Pseudo_map_position
  Reference: WBPaper00000639
    WBPaper00000772
    WBPaper00000918
    WBPaper00000928
    WBPaper00000963
    WBPaper00001187
    WBPaper00001497
    WBPaper00001695
    WBPaper00002615
    WBPaper00003696
    WBPaper00003787
    WBPaper00004756
    WBPaper00005432
    WBPaper00005605
    WBPaper00005650
    WBPaper00005851
    WBPaper00005897
    WBPaper00005976
    WBPaper00006047
    WBPaper00006465
    WBPaper00006533
    WBPaper00010085
    WBPaper00012750
    WBPaper00013029
    WBPaper00014033
    WBPaper00014098
    WBPaper00014602
    WBPaper00014605
    WBPaper00014652
    WBPaper00014789
    WBPaper00014815
    WBPaper00018335
    WBPaper00019010
    WBPaper00022083
    WBPaper00022221
    WBPaper00022623
    WBPaper00022850
    WBPaper00023016
    WBPaper00024325
    WBPaper00024557
    WBPaper00024560
    WBPaper00025088
    WBPaper00026172
    WBPaper00026974
    WBPaper00028419
    WBPaper00028660
    WBPaper00028782
    WBPaper00029409
    WBPaper00030825
    WBPaper00031046
    WBPaper00031124
    WBPaper00031923
    WBPaper00032232
    WBPaper00032575
    WBPaper00032638
    WBPaper00033954
    WBPaper00035663
    WBPaper00036153
    WBPaper00036354
    WBPaper00036396
    WBPaper00036514
    WBPaper00036898
    WBPaper00037498
    WBPaper00038237
    WBPaper00038491
    WBPaper00039504
    WBPaper00040407
    WBPaper00040821
    WBPaper00041564
    WBPaper00041799
    WBPaper00042772
    WBPaper00043089
    WBPaper00043968
    WBPaper00044186
    WBPaper00044405
    WBPaper00046775
    WBPaper00048461
    WBPaper00049142
    WBPaper00050463
    WBPaper00050838
    WBPaper00051442
    WBPaper00051554
    WBPaper00053178
    WBPaper00055090
    WBPaper00056225
    WBPaper00056958
    WBPaper00058426
    WBPaper00059256
    WBPaper00059354
    WBPaper00059545
    WBPaper00060156
    WBPaper00060487
    WBPaper00060685
    WBPaper00060896
    WBPaper00061133
    WBPaper00061585
    WBPaper00061877
    WBPaper00061998
    WBPaper00062052
    WBPaper00062357
    WBPaper00062418
    WBPaper00062518
    WBPaper00063941
    WBPaper00064130
    WBPaper00064255
    WBPaper00064354
    WBPaper00064442
    WBPaper00064479
    WBPaper00064601
    WBPaper00064634
    WBPaper00064675
    WBPaper00064733
    WBPaper00064833
    WBPaper00064894
    WBPaper00064908
    WBPaper00064977
    WBPaper00065000
    WBPaper00065156
    WBPaper00065720
    WBPaper00065749
    WBPaper00065841
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene