WormBase Tree Display for Gene: WBGene00001985
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| WBGene00001985 | SMap | S_parent | Sequence | C18E3 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | hop-1 | Person_evidence | WBPerson220 | |||||
| Sequence_name | C18E3.8 | ||||||||
| Molecular_name | C18E3.8 | ||||||||
| C18E3.8.1 | |||||||||
| CE08317 | |||||||||
| Other_name | CELE_C18E3.8 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | hop-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | hop | ||||||||
| Allele (48) | |||||||||
| Legacy_information | [Li X, Greenwald I] hop for Homolog Of Presenilin. No mutants known. hop-1(RNAi) has no obvious effect on WT, but leads to synthetic lethality in sel-12. Transgenic hop-1 rescues Egl phenotype of sel-12. Predicted gene C18E3.8 | ||||||||
| Strain | WBStrain00004785 | ||||||||
| WBStrain00008037 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (41) | |||||||||
| Ortholog (23) | |||||||||
| Paralog | WBGene00004769 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00004958 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | hop-1 encodes one of three C. elegans presenilins (the other two presenilins are encoded by sel-12 and spe-4); originally identified on the basis of its sequence similarity to SEL-12 and the human PS1 and PS2 presenilins, HOP-1 has been shown to function redundantly with SEL-12 in embryonic, larval, and germline development and thus, to likely function by regulating LIN-12/GLP-1 signaling; in addition, hop-1 can functionally substitute for sel-12 by rescuing the egg-laying and vulval development defects of sel-12 mutants; hop-1 transcription appears to be regulated, at least in part, by the C. elegans spr genes, some of which encode orthologs of the mammalian CoREST repressor complex. | Paper_evidence | WBPaper00002932 | |||||
| WBPaper00003421 | |||||||||
| WBPaper00005564 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 05 Mar 2008 00:00:00 | ||||||||
| Automated_description | Predicted to enable endopeptidase activity. Involved in several processes, including egg-laying behavior; positive regulation of Notch signaling pathway; and regulation of vulval development. Predicted to be located in several cellular components, including apical plasma membrane; cytoplasm; and plasma membrane bounded cell projection. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C18E3.8 | |||||||
| Corresponding_transcript | C18E3.8.1 | ||||||||
| Other_sequence | CRC04478_1 | ||||||||
| CR03774 | |||||||||
| Associated_feature | WBsf219254 | ||||||||
| Experimental_info | RNAi_result (15) | ||||||||
| Expr_pattern | Expr2273 | ||||||||
| Expr1020822 | |||||||||
| Expr1031154 | |||||||||
| Expr1144989 | |||||||||
| Expr2012537 | |||||||||
| Expr2030776 | |||||||||
| Drives_construct | WBCnstr00036540 | ||||||||
| Construct_product | WBCnstr00007295 | ||||||||
| WBCnstr00036540 | |||||||||
| Microarray_results (17) | |||||||||
| Expression_cluster (124) | |||||||||
| Interaction (228) | |||||||||
| WBProcess | WBbiopr:00000072 | ||||||||
| Map_info | Map | I | Position | -1.59708 | Error | 0.006668 | |||
| Positive | Positive_clone | C18E3 | Author_evidence | Li XJ | |||||
| Greenwald IS | |||||||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| Mapping_data | Multi_point | 4412 | |||||||
| 4507 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (60) | |||||||||
| Remark (2) | |||||||||
| Method | Gene |
