| WBGene00001981 | SMap | S_parent | Sequence | C44C10 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | hnd-1 | Person_evidence | WBPerson320 |
| | | Sequence_name | C44C10.8 |
| | | Molecular_name | C44C10.8 |
| | | | C44C10.8.1 |
| | | | CE05415 |
| | | Other_name | hlh-18 | Person_evidence | WBPerson346 |
| | | | hlh-22 | Person_evidence | WBPerson346 |
| | | | CELE_C44C10.8 | Accession_evidence | NDB | BX284606 |
| | | Public_name | hnd-1 |
| | DB_info | Database | AceView | gene | XM301 |
| | | | WormQTL | gene | WBGene00001981 |
| | | | WormFlux | gene | WBGene00001981 |
| | | | NDB | locus_tag | CELE_C44C10.8 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00001981|UniProtKB=Q18612 |
| | | | | family | PTHR23349 |
| | | | NCBI | gene | 183457 |
| | | | RefSeq | protein | NM_077551.4 |
| | | | SwissProt | UniProtAcc | Q18612 |
| | | | UniProt_GCRP | UniProtAcc | Q18612 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | hnd |
| | Allele (20) |
| | Strain | WBStrain00002580 |
| | | WBStrain00022621 |
| | | WBStrain00052024 |
| | RNASeq_FPKM (74) |
| | GO_annotation (13) |
| | Ortholog (32) |
| | Paralog | WBGene00001953 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00001954 | Caenorhabditis elegans | From_analysis | Panther |
| | | WBGene00001956 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00001957 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00001962 | Caenorhabditis elegans | From_analysis | Panther |
| | Structured_description | Concise_description | hnd-1 encodes a Hand bHLH transcription factor required for normal viability, gonadogenesis, and posterior body morphology; HND-1 is required for the formation of both somatic gonadal precursors and primordial germ cells, but not for later gonadogenesis; HND-1 is expressed embryogenesis in embryonic mesodermal precursor cells generating (mostly) body wall muscle, in somatic gonad precursor cells, and in some unidentified head cells; the primary defect in hnd-1 mutants may be, nonautonomously, in mesodermal precursor cells; somatic gonad precursor cells are normally generated in hnd-1 mutants, but not maintained. | Paper_evidence | WBPaper00006002 |
| | | | | Curator_confirmed | WBPerson567 |
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Automated_description | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in gonad development. Acts upstream of or within gonadal mesoderm development and positive regulation of muscle cell differentiation. Predicted to be located in nucleus. Expressed in several structures, including Daa; Dap; Dpa; Dpp; and somatic gonad precursor. Is an ortholog of human HAND1 (heart and neural crest derivatives expressed 1). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | C44C10.8 |
| | Corresponding_transcript | C44C10.8.1 |
| | Associated_feature | WBsf648568 |
| | | WBsf978347 |
| | | WBsf1007088 |
| | | WBsf1007089 |
| | | WBsf1007090 |
| | | WBsf1023920 |
| | | WBsf1023921 |
| | | WBsf236416 |
| | Transcription_factor | WBTranscriptionFactor000177 |
| Experimental_info | RNAi_result (35) |
| | Expr_pattern (14) |
| | Drives_construct (16) |
| | Construct_product | WBCnstr00015356 |
| | | WBCnstr00016002 |
| | | WBCnstr00021800 |
| | | WBCnstr00036543 |
| | Microarray_results (20) |
| | Expression_cluster | WBPaper00028867:PAL-1_induced_TF |
| | | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00032976:non_compensated_genes |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00033070:Rhine_downregulated |
| | | WBPaper00037682:sma-2_upregulated |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00040285:H2S_12hr_upregulated |
| | | WBPaper00041222:unc-120(st364)_downregulated |
| | | WBPaper00042477:rsr-2(RNAi)_upregulated_TilingArray |
| | | WBPaper00042561:smg-2(RNAi)_downregulated |
| | | WBPaper00044316:CH3HgCl_7.5uM_downregulated |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00045861:ash-2(tm1095)_upregulated |
| | | WBPaper00046805:csr-1(RNAi)_upregulated_Set1 |
| | | WBPaper00047132:skn-1(RNAi)_downregulated_glp-1(ts)-dependent |
| | | WBPaper00049098:heat-induced_hrde-1(tm1200) |
| | | WBPaper00050344:AFD-neuron_enriched |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053318:Aging_upregulated_mRNA_N2 |
| | | WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_embryo_SMARTseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00053814:15C_downregulated_OP50 |
| | | WBPaper00054493:hpl-2(tm1489)_downregulated |
| | | WBPaper00055013:hmg-3(bar24)_upregulated |
| | | WBPaper00055354:eat-2(ad1116)_downregulated |
| | | WBPaper00055354:Rapamycin-Psora-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_downregulated |
| | | WBPaper00055354:Rapamycin_downregulated |
| | | WBPaper00055354:Rifampicin-Psora_downregulated |
| | | WBPaper00055354:Rifampicin_downregulated |
| | | WBPaper00055386:daf-2(e1370)_downregulated |
| | | WBPaper00055386:eat-2(ad465)_downregulated |
| | | WBPaper00055482:Tunicamycin_upregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056161:hermaphrodite_enriched_siRNA |
| | | WBPaper00056167:Cry5B_upregulated |
| | | WBPaper00056330:glycine_upregulated |
| | | WBPaper00056443:DietaryRestriction_upregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056446:hsb-1(cg116)_upregulated |
| | | WBPaper00057006:DietaryRestriction_downregulated |
| | | WBPaper00058598:mex-3(eu149)_downregulated |
| | | WBPaper00058691:cfp-1(tm6369)_downregulated |
| | | WBPaper00058691:sin-3(tm1276)_downregulated |
| | | WBPaper00058948:PA14_upregulated |
| | | WBPaper00059224:tph-1(mg280)_upregulated |
| | | WBPaper00059334:sacy-1(depletion)_regulated |
| | | WBPaper00059728:5ug_cholesterol_downregulated |
| | | WBPaper00059728:20ug_cholesterol_downregulated |
| | | WBPaper00060445:ikb-1(nr2027)_upregulated_L1 |
| | | WBPaper00060445:nfki-1(cer1)_upregulated_L4 |
| | | WBPaper00060764:swsn-1(os22ts)_downregulated |
| | | WBPaper00061007:HB101_downregulated |
| | | WBPaper00061007:S.aquatilis_downregulated |
| | | WBPaper00061340:Body_wall_muscle |
| | | WBPaper00061340:GLR |
| | | WBPaper00061340:Z1_Z4 |
| | | WBPaper00061341:28C_24h_upregulated |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061424:Diet_MYb120_downregulated |
| | | WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection |
| | | WBPaper00061479:ubc-9(ne4833)_upregulated |
| | | WBPaper00061527:ZK1053.4-C08F1.6 |
| | | WBPaper00061613:human-alpha-Synuclein(A53T)_upregulated |
| | | WBPaper00061613:human-amyloid-beta_alpha-Synuclein(A53T)_upregulated |
| | | WBPaper00062156:jmjd-5(zr1234)_updownregulated |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00062456:doxycycline_downregulated_CB4856_transcript |
| | | WBPaper00062456:doxycycline_downregulated_N2_transcript |
| | | WBPaper00062585:hlh-26(ok1453)_downregulated_E.faecium |
| | | WBPaper00062590:Aging_upregulated_neuron |
| | | WBPaper00064509:static-magnetic-field_downregulated |
| | | WBPaper00064602:egl-9(sa307)_upregulated |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00064769:him-17(me24)_downregulated |
| | | WBPaper00064999:miR-229-64-65-66_upregulated |
| | | WBPaper00065005:sams-4(RNAi)_upregulated |
| | | WBPaper00065096:25C_vs_20C_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065096:npr-8(ok1439)_downregulated_Day1_25C |
| | | WBPaper00065096:npr-8(ok1439)_downregulated_Day10_25C |
| | | WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977) |
| | | WBPaper00065835:Day11_vs_Day1_downregulated |
| | | WBPaper00065975:P-body_vs_oocyte_enriched |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066004:tdp-1(csb38)_downregulated |
| | | WBPaper00066110:Cisplatin_downregulated_diploid |
| | | WBPaper00066110:Doxorubicin_downregulated_diploid |
| | | WBPaper00066110:tetraploid_vs_diploid_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | WBPaper00066232:hsf-1(RNAi)_downregulated_ash-2 |
| | | WBPaper00066232:hsf-1(RNAi)_downregulated_WT |
| | | cgc4386_cluster_4_3 |
| | | cgc4489_group_5 |
| | | WBPaper00025032:cluster_60 |
| | | WBPaper00025032:PAL-1_target_genes |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00036130:mir-243_down_regulated |
| | | WBPaper00036286:Pattern_D |
| | | WBPaper00038427:lin-54_embryo_changed |
| | | WBPaper00040184:hcf-1up_sir-2.1up_daf-2nc |
| | | WBPaper00041174:environmental |
| | | WBPaper00041174:genotypic |
| | | WBPaper00041174:genotypic_and_environmental |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00046853:AOBr_M.aeruginosa-batch-culture_upregulated |
| | | WBPaper00048989:N2_allantoin_upregulated |
| | | WBPaper00050538:Fasting_upregulated |
| | | WBPaper00056330:mrps-5(RNAi)_downregulated |
| | | [cgc5767]:cluster_2 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(41_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | Interaction (93) |
| | Anatomy_function | WBbtf0224 |
| | | WBbtf0225 |
| | | WBbtf0226 |
| Map_info | Map | X | Position | 6.02264 | Error | 0.198527 |
| | Positive | Positive_clone | C44C10 | Inferred_automatically | From CDS info |
| | | | | | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4411 |
| | Pseudo_map_position |
| Reference (22) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
