WormBase Tree Display for Gene: WBGene00001966
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| WBGene00001966 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | C17C3 | ||||||
| Identity | Version | 2 | |||||||
| Name | CGC_name | hlh-27 | Person_evidence | WBPerson346 | |||||
| Sequence_name | C17C3.10 | ||||||||
| Molecular_name | C17C3.10 | ||||||||
| C17C3.10.1 | |||||||||
| CE46787 | |||||||||
| Other_name | CELE_C17C3.10 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | hlh-27 | ||||||||
| DB_info | Database | AceView | gene | 2F828 | |||||
| WormQTL | gene | WBGene00001966 | |||||||
| WormFlux | gene | WBGene00001966 | |||||||
| NDB | locus_tag | CELE_C17C3.10 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00001966|UniProtKB=Q18056 | |||||||
| family | PTHR10985 | ||||||||
| NCBI | gene | 182719 | |||||||
| RefSeq | protein | NM_062664.4 | |||||||
| TREEFAM | TREEFAM_ID | TF322171 | |||||||
| TrEMBL | UniProtAcc | Q18056 | |||||||
| UniProt_GCRP | UniProtAcc | Q18056 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 03 Oct 2011 10:56:13 | WBPerson1867 | Event | Split_into | WBGene00219272 | ||||
| Split_into | WBGene00219272 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | hlh | ||||||||
| Allele (17) | |||||||||
| Strain | WBStrain00051158 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00060095 | ||||||||
| 00060096 | |||||||||
| 00060097 | |||||||||
| 00060098 | |||||||||
| 00060099 | |||||||||
| 00060100 | |||||||||
| 00109819 | |||||||||
| Ortholog (22) | |||||||||
| Paralog | WBGene00001964 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Inparanoid_8 | |||||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00001965 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Inparanoid_8 | |||||||||
| WormBase-Compara | |||||||||
| WBGene00003008 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00001968 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Inparanoid_8 | |||||||||
| WormBase-Compara | |||||||||
| WBGene00001967 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Inparanoid_8 | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | hlh-27 encodes a REF-1-like protein with two bHLH domains, that represses lag-2 transcription in ABa descendants (in response to a Notch signal, redundantly with REF-1, HLH-25, HLH-26, HLH-29, and perhaps HLH-28) and tbx-37 transcription in EMS descendants (independently of Notch, redundantly with REF-1, HLH-26, HLH-29, and perhaps HLH-28); lag-2 repression by HLH-27 may require UNC-37; HLH-27's paralogs include HLH-25 through HLH-29 and (more distantly) REF-1; hlh-27 is transcribed in the early MS lineage, probably due to MED-1/2 binding of clustered sites in the hlh-27 promoter region; HLH-27 is expressed in ABp granddaughters ~25 minutes after ABp first contacts an APX-1-expressing cell, and in ABa descendants after a second Notch interaction; HLH-27 is also expressed in four EMS granddaughters (MSaa, MSap, MSpa, MSpp) beginning at the 24-cell stage, in a SKN-1-dependent manner; HLH-27 is required for embryonic viability in mass RNAi assays. | Paper_evidence | WBPaper00006395 | |||||
| WBPaper00025235 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 18 Apr 2008 00:00:00 | ||||||||
| Automated_description | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anterior/posterior pattern specification; regulation of neurogenesis; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in several structures, including ABpla; ABplp; ABprp; MSaa; and MSpa. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C17C3.10 | |||||||
| Corresponding_CDS_history | C17C3.10:wp228 | ||||||||
| Corresponding_transcript | C17C3.10.1 | ||||||||
| Associated_feature | WBsf978830 | ||||||||
| WBsf981202 | |||||||||
| WBsf223060 | |||||||||
| Transcription_factor | WBTranscriptionFactor000074 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00010905 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00010899 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00084010 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00040773 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00024579 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00040785 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00027179 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr3496 | ||||||||
| Expr8068 | |||||||||
| Expr1028370 | |||||||||
| Expr1144810 | |||||||||
| Expr2012502 | |||||||||
| Expr2030741 | |||||||||
| Drives_construct | WBCnstr00005213 | ||||||||
| WBCnstr00011428 | |||||||||
| WBCnstr00015158 | |||||||||
| WBCnstr00036554 | |||||||||
| Construct_product | WBCnstr00005213 | ||||||||
| WBCnstr00016893 | |||||||||
| WBCnstr00036554 | |||||||||
| Microarray_results | SMD_C17C3.10 | ||||||||
| SMD_C17C3.11 | |||||||||
| A_12_P151226 | |||||||||
| Expression_cluster (48) | |||||||||
| Interaction (182) | |||||||||
| Map_info (3) | |||||||||
| Reference | WBPaper00025235 | ||||||||
| WBPaper00027287 | |||||||||
| WBPaper00027309 | |||||||||
| WBPaper00029033 | |||||||||
| WBPaper00034761 | |||||||||
| WBPaper00062117 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
