hlh-15 encodes one of 42 C. elegans basic helix-loop-helix transcription factors; HLH-15 physically interacts with HLH-2, the C. elegans E/Daughterless homolog; an hlh-15::gfp promoter fusion is expressed in head and tail neurons.
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in positive regulation of DNA-templated transcription. Acts upstream of or within determination of adult lifespan. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism. Is an ortholog of human NHLH2 (nescient helix-loop-helix 2).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.