WormBase Tree Display for Gene: WBGene00001842
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| WBGene00001842 | SMap | S_parent | Sequence | ZK287 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | her-1 | Person_evidence | WBPerson261 | |||||
| Sequence_name | ZK287.8 | ||||||||
| Molecular_name | ZK287.8a | ||||||||
| ZK287.8a.1 | |||||||||
| CE06617 | |||||||||
| ZK287.8b | |||||||||
| CE46124 | |||||||||
| ZK287.8b.1 | |||||||||
| Other_name | CELE_ZK287.8 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | her-1 | ||||||||
| DB_info | Database | AceView | gene | 5K181 | |||||
| WormQTL | gene | WBGene00001842 | |||||||
| WormFlux | gene | WBGene00001842 | |||||||
| NDB | locus_tag | CELE_ZK287.8 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00001842|UniProtKB=P34704 | |||||||
| family | PTHR37979 | ||||||||
| NCBI | gene | 179360 | |||||||
| RefSeq | protein | NM_001029140.5 | |||||||
| NM_001029139.3 | |||||||||
| SwissProt | UniProtAcc | P34704 | |||||||
| TrEMBL | UniProtAcc | Q65ZB2 | |||||||
| UniProt_GCRP | UniProtAcc | P34704 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:25 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | her | ||||||||
| Reference_allele | WBVar00144068 | ||||||||
| WBVar00089681 | |||||||||
| Allele (115) | |||||||||
| Legacy_information | Class 1 (loss-of-function) : e1518 : XX animals wildtype XO animals transformed into fertile hermaphrodites. ES3 (XO). Similar phenotype in e1518/Df. NA > 12 (e1520 e1561ts etc.). | ||||||||
| Class 2 (gain-of-function) : n695sd ts : XO animals wildtype XX animals partly masculinized egglaying defective hermaphrodites; n695/+ XX animals slightly masculinized. ES2 (XX). NA1. Intragenic revertants have Class 1 phenotype. NA (ird) > 4. | |||||||||
| See also e1518, e1519, e1520, e2296, n695, n826, n827, y8, y10, y14 | |||||||||
| [C.elegansII] e1518 : XX animals WT, XO animals transformed into fertile hermaphrodites. ES3 (XO). Similar phenotype in e1518/Df. OA>20: e1520, e1561ts (XO fertile male 15C, fertile hermaphrodite25C), q428ts (very weak Her), etc. Also gain-of-function alleles: n695sd,ts(XO animals WT, XX animals partly masculinized Egl hermaphrodites; n695/+ XX animals slightly masculinized),y101 (stronger masculinization, still incomplete). Intragenic revertants are recessive Her-1 alleles:n695n826, y1hv101 (viable deletion), etc. ES2 (XX). NA1. Intragenic revertants have Class 1 phenotype. Cloned: 0.8 and 1.2 kb transcripts, XO specific;1.2 kb transcript necessary and sufficient, encodes175 aa predicted cysteine-rich novel protein with signal sequence. [Hodgkin 1980; Perry et al. 1993, 1994; NT; PA] | |||||||||
| Strain (11) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00044186 | ||||||||
| 00044187 | |||||||||
| 00044188 | |||||||||
| 00044189 | |||||||||
| 00044190 | |||||||||
| 00044191 | |||||||||
| Ortholog (26) | |||||||||
| Structured_description | Concise_description | her-1 generates two transcripts, the larger of which encodes a small,secreted, cysteine-rich protein (HER-1A) required for normal sexdetermination in wild-type XO male animals, while being dispensable forsex determination in XX hermaphrodites; transcription of her-1 in XXanimals is repressed by SDC-2; HER-1A protein has two all-helicaldomains, with fourteen conserved cysteine residues forming sevendisulfide bonds, at least eight of which residues are critical forfunction in vivo; HER-1A has no known homologs except in other nematodes(e.g., Brugia malayi), and does not structurally resemble otherwell-known secreted proteins; HER-1A inhibits the receptor TRA-2A invivo, and binds it in vitro; HER-1A functions nonautonomously andrequires a signal sequence for biological activity; the her-1(n695gf)mutation alters a site in the her-1 promoter bound by SDC-2, partiallytransforms XX animals into phenotypic males, and requires sup-26 andsup-27 to do so. | Paper_evidence | WBPaper00000498 | |||||
| WBPaper00001067 | |||||||||
| WBPaper00001416 | |||||||||
| WBPaper00001496 | |||||||||
| WBPaper00001692 | |||||||||
| WBPaper00002034 | |||||||||
| WBPaper00003644 | |||||||||
| WBPaper00005215 | |||||||||
| WBPaper00005578 | |||||||||
| WBPaper00024344 | |||||||||
| Person_evidence | WBPerson479 | ||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 13 Feb 2007 00:00:00 | ||||||||
| Automated_description | Enables signaling receptor binding activity. Involved in male sex determination. Located in extracellular region. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | ZK287.8a | |||||||
| ZK287.8b | |||||||||
| Corresponding_CDS_history | ZK287.8b:wp227 | ||||||||
| Corresponding_transcript | ZK287.8a.1 | ||||||||
| ZK287.8b.1 | |||||||||
| Other_sequence | FD515802.1 | ||||||||
| CSC02098_1 | |||||||||
| Associated_feature | WBsf019092 | ||||||||
| WBsf019093 | |||||||||
| WBsf647101 | |||||||||
| WBsf661583 | |||||||||
| WBsf1000974 | |||||||||
| WBsf1000975 | |||||||||
| WBsf1000976 | |||||||||
| WBsf1020212 | |||||||||
| WBsf1020213 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00021950 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00059334 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00087454 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00030278 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1391 | ||||||||
| Expr1019921 | |||||||||
| Expr1162763 | |||||||||
| Expr2012399 | |||||||||
| Expr2030635 | |||||||||
| Drives_construct | WBCnstr00000369 | ||||||||
| WBCnstr00000370 | |||||||||
| WBCnstr00036652 | |||||||||
| Construct_product | WBCnstr00036652 | ||||||||
| WBCnstr00040211 | |||||||||
| Microarray_results (27) | |||||||||
| Expression_cluster (121) | |||||||||
| Interaction (125) | |||||||||
| WBProcess | WBbiopr:00000056 | ||||||||
| Map_info | Map | V | Position | 2.07413 | Error | 0.004197 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | nDf31 | |||||||
| ctDp11 | |||||||||
| Positive_clone | CT#4 | ||||||||
| ZK287 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | 2_point | 633 | |||||||
| 634 | |||||||||
| Multi_point | 329 | ||||||||
| 544 | |||||||||
| 545 | |||||||||
| 546 | |||||||||
| 547 | |||||||||
| 739 | |||||||||
| 1786 | |||||||||
| 3892 | |||||||||
| Pos_neg_data | 378 | ||||||||
| 1736 | |||||||||
| 1737 | |||||||||
| Reference (253) | |||||||||
| Picture | WBPicture0000013095 | ||||||||
| Method | Gene |
