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WormBase Tree Display for Gene: WBGene00001824

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Name Class

WBGene00001824EvidenceCGC_data_submission
SMapS_parentSequenceF13D11
IdentityVersion1
NameCGC_namehbl-1Person_evidenceWBPerson698
Sequence_nameF13D11.2
Molecular_nameF13D11.2a
F13D11.2a.1
CE27956
F13D11.2b
CE23646
F13D11.2b.1
Other_namelin-57
CELE_F13D11.2Accession_evidenceNDBBX284606
Public_namehbl-1
DB_infoDatabaseWormQTLgeneWBGene00001824
WormFluxgeneWBGene00001824
NDBlocus_tagCELE_F13D11.2
PanthergeneCAEEL|WormBase=WBGene00001824|UniProtKB=Q9XYD3
familyPTHR24392
NCBIgene180848
RefSeqproteinNM_001047778.5
NM_001047779.5
SwissProtUniProtAccQ9XYD3
TREEFAMTREEFAM_IDTF326588
TrEMBLUniProtAccQ27GU0
UniProt_GCRPUniProtAccQ9XYD3
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:25WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classhbl
Allele (73)
Possibly_affected_byWBVar02152888
Strain (11)
RNASeq_FPKM (74)
GO_annotation (19)
Ortholog (32)
ParalogWBGene00016189Caenorhabditis elegansFrom_analysisPanther
WBGene00005009Caenorhabditis elegansFrom_analysisPanther
WBGene00003033Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00008762Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00012385Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionhbl-1 encodes a C2H2-type zinc finger transcription factor related to Drosophila hunchback; hbl-1 is a heterochronic gene that plays an essential role in regulating developmental timing during postembryonic development; accordingly, mutations in hbl-1 affect locomotion, egg laying, body morphology, and hypodermal differentiation; hbl-1 is expressed in hypodermal precursor cells, neuronal precursor cells, and pharyngeal cells during embryogenesis and is primarily expressed in neurons during larval development; hbl-1 expression is negatively regulated by the let-7 miRNA whose expression is, in turn, negatively regulated by HBL-1 in a negative feedback loop.Paper_evidenceWBPaper00003392
WBPaper00005908
WBPaper00005909
WBPaper00034754
Curator_confirmedWBPerson48
WBPerson1843
Date_last_updated20 Aug 2009 00:00:00
Automated_descriptionEnables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including egg-laying behavior; negative regulation of transcription by RNA polymerase II; and nematode larval development. Located in nucleus. Expressed in several structures, including body wall musculature; germ line; hypodermis; neurons; and ventral nerve cord.Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSF13D11.2a
F13D11.2b
Corresponding_CDS_historyF13D11.2:wp155
Corresponding_transcriptF13D11.2a.1
F13D11.2b.1
Other_sequenceJI462622.1
JI164262.1
Oden_isotig23540
SC01112
JI164529.1
MI07402
MIC06569_1
GR977958.1
Associated_featureWBsf019183
WBsf019184
WBsf019185
WBsf019186
WBsf019187
WBsf019188
WBsf019189
WBsf019190
WBsf019191
WBsf019192
WBsf019193
WBsf019194
WBsf662821
WBsf662822
WBsf662823
WBsf662824
WBsf662825
WBsf662826
WBsf662827
WBsf662828
WBsf662829
WBsf662830
WBsf716625
WBsf716626
WBsf718598
WBsf978668
WBsf1005398
WBsf1005399
WBsf1005400
WBsf1005401
WBsf1005402
WBsf1005403
WBsf1005404
WBsf1023016
WBsf1023017
WBsf1023018
WBsf1023019
WBsf1023020
WBsf1023021
WBsf235756
WBsf235757
WBsf235758
WBsf235759
Transcription_factorWBTranscriptionFactor000175
Experimental_infoRNAi_result (78)
Expr_pattern (15)
Drives_construct (11)
Construct_productWBCnstr00000374
WBCnstr00009982
WBCnstr00017352
WBCnstr00019440
WBCnstr00036665
Microarray_results (27)
Expression_cluster (229)
Interaction (217)
Anatomy_functionWBbtf0427
WBProcessWBbiopr:00000083
Map_infoMapXPosition-4.26909Error0.011372
PositivePositive_cloneF13D11Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point4396
Pseudo_map_position
Reference (125)
RemarkSequence connection from [Abrahante JE, Rougvie AE]
old_name lin-57 becomes new_name hbl-1 from [Abrahante JE, Rougvie AE].
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene