WormBase Tree Display for Gene: WBGene00001693
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| WBGene00001693 | Evidence | Paper_evidence | WBPaper00003717 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | CHROMOSOME_X | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | grd-4 | Person_evidence | WBPerson83 | |||||
| Sequence_name | T01B10.1 | ||||||||
| Molecular_name | T01B10.1 | ||||||||
| T01B10.1.1 | |||||||||
| CE07455 | |||||||||
| Other_name | T01B10 | Paper_evidence | WBPaper00002823 | ||||||
| CELE_T01B10.1 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | grd-4 | ||||||||
| DB_info | Database | AceView | gene | XJ119 | |||||
| WormQTL | gene | WBGene00001693 | |||||||
| NDB | locus_tag | CELE_T01B10.1 | |||||||
| NCBI | gene | 24104827 | |||||||
| RefSeq | protein | NM_001307906.4 | |||||||
| TREEFAM | TREEFAM_ID | TF316923 | |||||||
| TrEMBL | UniProtAcc | O02154 | |||||||
| UniProt_GCRP | UniProtAcc | O02154 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:25 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | grd | ||||||||
| Allele (18) | |||||||||
| Strain | WBStrain00002347 | ||||||||
| WBStrain00051458 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| Ortholog (18) | |||||||||
| Paralog (24) | |||||||||
| Structured_description | Concise_description | grd-4 encodes a hedgehog-like protein, with an N-terminal signalsequence and a C-terminal Ground domain; the Ground domain is predictedto form a cysteine-crosslinked protein involved in intercellularsignalling, and it has subtle similarity to the N-terminal Hedge domainof HEDGEHOG proteins; GRD-4 is weakly required for normal molting; GRD-4is also required for normal adult alae formation, growth to full size,and locomotion; all of these requirements may reflect common defects incholesterol-dependent hedgehog-like signalling or in vesicletrafficking. | Paper_evidence | WBPaper00003717 | |||||
| WBPaper00026841 | |||||||||
| WBPaper00027263 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 05 Nov 2006 00:00:00 | ||||||||
| Automated_description | Enriched in RME; dopaminergic neurons; and hypodermis based on tiling array; RNA-seq; and single-cell RNA-seq studies. Is affected by several genes including daf-16; daf-2; and skn-1 based on microarray; tiling array; and RNA-seq studies. Is affected by twenty-three chemicals including cholesterol; lathosterol; and methylmercuric chloride based on microarray and RNA-seq studies. Is predicted to encode a protein with the following domain: Ground-like domain. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | T01B10.1 | |||||||
| Corresponding_transcript | T01B10.1.1 | ||||||||
| Associated_feature | WBsf1006176 | ||||||||
| WBsf1023427 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00076972 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00017926 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00076993 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00112701 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00034989 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00052066 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00077018 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram1692 | ||||||||
| Expr4419 | |||||||||
| Expr1016083 | |||||||||
| Expr1155697 | |||||||||
| Expr2012234 | |||||||||
| Expr2030470 | |||||||||
| Drives_construct | WBCnstr00003016 | ||||||||
| WBCnstr00011980 | |||||||||
| WBCnstr00036763 | |||||||||
| Construct_product | WBCnstr00036763 | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (196) | |||||||||
| Interaction (133) | |||||||||
| WBProcess | WBbiopr:00000123 | ||||||||
| Map_info | Map | X | Position | 0.093402 | |||||
| Positive | Positive_clone | T01B10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00002823 | ||||||||
| WBPaper00003717 | |||||||||
| WBPaper00025183 | |||||||||
| WBPaper00026841 | |||||||||
| WBPaper00028754 | |||||||||
| WBPaper00029087 | |||||||||
| WBPaper00031588 | |||||||||
| WBPaper00040160 | |||||||||
| WBPaper00064105 | |||||||||
| Remark | grd-4 contains ground domain only. grd-4 and grd-14 form a cluster, grd-4 and grd-14 are paralogous to the grd-3 and grd-13 cluster | Paper_evidence | WBPaper00003717 | ||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
