WormBase Tree Display for Gene: WBGene00001693

WBGene00001693 Evidence: Paper_evidence: WBPaper00003717
  SMap: S_parent: Sequence: CHROMOSOME_X
  Identity: Version: 1
    Name: CGC_name: grd-4 Person_evidence: WBPerson83
      Sequence_name: T01B10.1
      Molecular_name: T01B10.1
        T01B10.1.1
        CE07455
      Other_name: T01B10 Paper_evidence: WBPaper00002823
        CELE_T01B10.1 Accession_evidence: NDB BX284606
      Public_name: grd-4
    DB_info: Database: AceView gene XJ119
        WormQTL gene WBGene00001693
        NDB locus_tag CELE_T01B10.1
        NCBI gene 24104827
        RefSeq protein NM_001307906.4
        TREEFAM TREEFAM_ID TF316923
        TrEMBL UniProtAcc O02154
        UniProt_GCRP UniProtAcc O02154
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:25 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: grd
    Allele (18)
    Strain: WBStrain00002347
      WBStrain00051458
    RNASeq_FPKM (74)
    Ortholog (18)
    Paralog (24)
    Structured_description: Concise_description: grd-4 encodes a hedgehog-like protein, with an N-terminal signalsequence and a C-terminal Ground domain; the Ground domain is predictedto form a cysteine-crosslinked protein involved in intercellularsignalling, and it has subtle similarity to the N-terminal Hedge domainof HEDGEHOG proteins; GRD-4 is weakly required for normal molting; GRD-4is also required for normal adult alae formation, growth to full size,and locomotion; all of these requirements may reflect common defects incholesterol-dependent hedgehog-like signalling or in vesicletrafficking. Paper_evidence: WBPaper00003717
            WBPaper00026841
            WBPaper00027263
          Curator_confirmed: WBPerson48
            WBPerson567
          Date_last_updated: 05 Nov 2006 00:00:00
      Automated_description: Enriched in RME; dopaminergic neurons; and hypodermis based on tiling array; RNA-seq; and single-cell RNA-seq studies. Is affected by several genes including daf-16; daf-2; and skn-1 based on microarray; tiling array; and RNA-seq studies. Is affected by twenty-three chemicals including cholesterol; lathosterol; and methylmercuric chloride based on microarray and RNA-seq studies. Is predicted to encode a protein with the following domain: Ground-like domain. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: T01B10.1
    Corresponding_transcript: T01B10.1.1
    Associated_feature: WBsf1006176
      WBsf1023427
  Experimental_info: RNAi_result: WBRNAi00076972 Inferred_automatically: RNAi_primary
      WBRNAi00017926 Inferred_automatically: RNAi_primary
      WBRNAi00076993 Inferred_automatically: RNAi_primary
      WBRNAi00112701 Inferred_automatically: RNAi_primary
      WBRNAi00034989 Inferred_automatically: RNAi_primary
      WBRNAi00052066 Inferred_automatically: RNAi_primary
      WBRNAi00077018 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram1692
      Expr4419
      Expr1016083
      Expr1155697
      Expr2012234
      Expr2030470
    Drives_construct: WBCnstr00003016
      WBCnstr00011980
      WBCnstr00036763
    Construct_product: WBCnstr00036763
    Microarray_results (19)
    Expression_cluster (196)
    Interaction: WBInteraction000113294
      WBInteraction000126770
      WBInteraction000134911
      WBInteraction000147605
      WBInteraction000157157
      WBInteraction000164197
      WBInteraction000164938
      WBInteraction000168974
      WBInteraction000179348
      WBInteraction000180573
      WBInteraction000181233
      WBInteraction000181386
      WBInteraction000187796
      WBInteraction000193046
      WBInteraction000195744
      WBInteraction000199209
      WBInteraction000199830
      WBInteraction000200148
      WBInteraction000205898
      WBInteraction000209317
      WBInteraction000212749
      WBInteraction000219371
      WBInteraction000219749
      WBInteraction000220014
      WBInteraction000221130
      WBInteraction000221768
      WBInteraction000223962
      WBInteraction000229626
      WBInteraction000233518
      WBInteraction000238840
      WBInteraction000244924
      WBInteraction000245496
      WBInteraction000248854
      WBInteraction000249382
      WBInteraction000250632
      WBInteraction000252131
      WBInteraction000254248
      WBInteraction000261605
      WBInteraction000265575
      WBInteraction000266067
      WBInteraction000266792
      WBInteraction000272528
      WBInteraction000276449
      WBInteraction000279578
      WBInteraction000281537
      WBInteraction000281732
      WBInteraction000284998
      WBInteraction000285087
      WBInteraction000287887
      WBInteraction000291304
      WBInteraction000299706
      WBInteraction000300382
      WBInteraction000300526
      WBInteraction000300880
      WBInteraction000301276
      WBInteraction000302215
      WBInteraction000303886
      WBInteraction000306683
      WBInteraction000306828
      WBInteraction000308356
      WBInteraction000309079
      WBInteraction000309874
      WBInteraction000310461
      WBInteraction000319796
      WBInteraction000321445
      WBInteraction000323613
      WBInteraction000323998
      WBInteraction000328664
      WBInteraction000330083
      WBInteraction000333018
      WBInteraction000337320
      WBInteraction000345006
      WBInteraction000345729
      WBInteraction000345875
      WBInteraction000349625
      WBInteraction000350844
      WBInteraction000352668
      WBInteraction000354071
      WBInteraction000355425
      WBInteraction000358399
      WBInteraction000359030
      WBInteraction000359508
      WBInteraction000360419
      WBInteraction000361054
      WBInteraction000362376
      WBInteraction000363064
      WBInteraction000363855
      WBInteraction000376880
      WBInteraction000387101
      WBInteraction000388812
      WBInteraction000388920
      WBInteraction000389353
      WBInteraction000389993
      WBInteraction000390821
      WBInteraction000391121
      WBInteraction000393884
      WBInteraction000394862
      WBInteraction000395109
      WBInteraction000403034
      WBInteraction000403560
      WBInteraction000406376
      WBInteraction000406468
      WBInteraction000407309
      WBInteraction000407951
      WBInteraction000408388
      WBInteraction000409072
      WBInteraction000411096
      WBInteraction000416379
      WBInteraction000417644
      WBInteraction000417912
      WBInteraction000419566
      WBInteraction000423424
      WBInteraction000426484
      WBInteraction000429604
      WBInteraction000432291
      WBInteraction000434230
      WBInteraction000435822
      WBInteraction000439538
      WBInteraction000440089
      WBInteraction000442444
      WBInteraction000442688
      WBInteraction000443934
      WBInteraction000447504
      WBInteraction000447997
      WBInteraction000448643
      WBInteraction000450949
      WBInteraction000451588
      WBInteraction000451953
      WBInteraction000454456
      WBInteraction000455068
      WBInteraction000456728
      WBInteraction000458227
      WBInteraction000461899
    WBProcess: WBbiopr:00000123
  Map_info: Map: X Position: 0.093402
    Positive: Positive_clone: T01B10 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00002823
    WBPaper00003717
    WBPaper00025183
    WBPaper00026841
    WBPaper00028754
    WBPaper00029087
    WBPaper00031588
    WBPaper00040160
    WBPaper00064105
  Remark: grd-4 contains ground domain only. grd-4 and grd-14 form a cluster, grd-4 and grd-14 are paralogous to the grd-3 and grd-13 cluster Paper_evidence: WBPaper00003717
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene