WormBase Tree Display for Gene: WBGene00001647
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| WBGene00001647 | SMap | S_parent | Sequence | T23G11 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | gna-2 | |||||||
| Sequence_name | T23G11.2 | ||||||||
| Molecular_name | T23G11.2 | ||||||||
| T23G11.2.1 | |||||||||
| CE16458 | |||||||||
| Other_name | CELE_T23G11.2 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | gna-2 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:25 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | gna | ||||||||
| Allele (20) | |||||||||
| Strain | WBStrain00035935 | ||||||||
| WBStrain00036018 | |||||||||
| WBStrain00040603 | |||||||||
| WBStrain00040605 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (18) | |||||||||
| Contained_in_operon | CEOP1989 | ||||||||
| Ortholog (38) | |||||||||
| Paralog | WBGene00001646 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | gna-2 encodes a glucosamine 6-phosphate N-acetyltransferase required forsynthesis of UDP-N-acetylglucosamine (UDP-GlcNAc), N-acetylgalactosamine(UDP-GalNAc), alpha-GalNAc-modifications of mucin-like proteins, andchitin; GNA-2 is also required for eggshell synthesis and osmoticintegrity, progression past meiosis metaphase I, error-free chromosomalsegregation during meiosis, polar body extrusion, association of thesperm pronucleus/centrosome complex (SPCC) with the early embryoniccortex, localization of PAR-2 in early embryos, posterior localizationof P granules or PIE-1, and pseudocleavage; gna-2 transcription iselevated during oogenesis; gna-2 mRNA is posttranslationally inhibitedboth by GLD-1 repression and by nonsense-mediated mRNA decay (NMD), withGLD-1 predominating in distal gonads and NMD (incompletely)predominating in proximal ones; gna-2 mRNA has two upstream open readingframes (uORFs) with premature stop codons, which normally cause NMD ofthis mRNA unless it is protected by GLD-1 binding to the gna-2 mRNA's 5'UTR; conversely, gna-2 mRNA is translationally repressed by bound GLD-1during pachytene meiosis, and must be freed from this repression duringdiplotene meiosis for eggshell synthesis to proceed; gna-2(qa705) issuppressed by sup-46 mutations, but only in a gna-1(+) background. | Paper_evidence | WBPaper00002207 | |||||
| WBPaper00004402 | |||||||||
| WBPaper00004651 | |||||||||
| WBPaper00004886 | |||||||||
| WBPaper00006390 | |||||||||
| WBPaper00006534 | |||||||||
| WBPaper00018602 | |||||||||
| WBPaper00025054 | |||||||||
| WBPaper00028588 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 07 Apr 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable glucosamine 6-phosphate N-acetyltransferase activity and monosaccharide binding activity. Involved in chitin biosynthetic process and eggshell formation. Predicted to be located in intracellular membrane-bounded organelle. Is an ortholog of human GNPNAT1 (glucosamine-phosphate N-acetyltransferase 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | T23G11.2 | |||||||
| Corresponding_transcript | T23G11.2.1 | ||||||||
| Other_sequence (43) | |||||||||
| Associated_feature | WBsf643480 | ||||||||
| WBsf656564 | |||||||||
| WBsf976819 | |||||||||
| WBsf976820 | |||||||||
| WBsf218064 | |||||||||
| Experimental_info | RNAi_result (25) | ||||||||
| Expr_pattern | Expr6750 | ||||||||
| Expr1017596 | |||||||||
| Expr1030987 | |||||||||
| Expr1157509 | |||||||||
| Expr2012157 | |||||||||
| Expr2030393 | |||||||||
| Drives_construct | WBCnstr00004045 | ||||||||
| WBCnstr00036799 | |||||||||
| Construct_product | WBCnstr00036799 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (200) | |||||||||
| Interaction (272) | |||||||||
| Map_info | Map | I | Position | 2.28273 | Error | 0.00984 | |||
| Positive | Positive_clone | T23G11 | Person_evidence | WBPerson1822 | |||||
| WBPerson5637 | |||||||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| T23G11 fragment 20340-23478 | |||||||||
| Mapping_data | Multi_point | 4366 | |||||||
| Pseudo_map_position | |||||||||
| Reference (15) | |||||||||
| Remark | Gene description from Johnston, WL and Dennis, JW [020924 ck1] | ||||||||
| The exact positive_clone referred to is T23G11 fragment 20340-23478 [Johnston, WL and Denis, JW] [021007 ck1] | |||||||||
| Postitive method is stable transformation rescue | |||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
