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WormBase Tree Display for Gene: WBGene00001592

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Name Class

WBGene00001592SMapS_parentSequenceF25F8
IdentityVersion1
NameCGC_nameglc-2Person_evidenceWBPerson32
Sequence_nameF25F8.2
Molecular_nameF25F8.2
F25F8.2.1
CE09636
Other_nameavm-2
GluCl betaPaper_evidenceWBPaper00005494
WBPaper00044702
WBPaper00051057
CELE_F25F8.2Accession_evidenceNDBBX284601
Public_nameglc-2
DB_infoDatabaseAceViewgene1F454
WormQTLgeneWBGene00001592
WormFluxgeneWBGene00001592
NDBlocus_tagCELE_F25F8.2
PanthergeneCAEEL|WormBase=WBGene00001592|UniProtKB=Q17328
familyPTHR18945
NCBIgene172103
RefSeqproteinNM_059069.4
SwissProtUniProtAccQ17328
UniProt_GCRPUniProtAccQ17328
OMIMgene138491
305990
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:25WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classglc
Allele (45)
StrainWBStrain00028915
WBStrain00035700
WBStrain00036012
WBStrain00035006
RNASeq_FPKM (74)
GO_annotation (28)
Ortholog (51)
Paralog (100)
Structured_descriptionConcise_descriptionglc-2 encodes the beta subunit of a glutamate-gated chloride channel; in vivo, GLC-2 is capable of forming homomeric glutamate-activated channels, as well as heteromeric channels with GLC-1 that can be activated by glutamate and avermectins, antihelmintics that inhibit pharyngeal pumping; as loss of glc-2 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of GLC-2 in development and/or behavior is not yet known; however, GLC-2 expression is generally restricted to the pm4 pharyngeal muscles of larvae and adults, suggesting a role for GLC-2 in regulation of glutamatergic inhibition of pharyngeal pumping.Paper_evidenceWBPaper00002049
WBPaper00002808
WBPaper00006139
Curator_confirmedWBPerson1843
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionEnables extracellularly glutamate-gated chloride channel activity. Involved in chloride transmembrane transport. Located in plasma membrane. Expressed in pm4. Human ortholog(s) of this gene implicated in hyperekplexia 1 and syndromic X-linked intellectual disability Pilorge type. Is an ortholog of human GLRA1 (glycine receptor alpha 1); GLRA2 (glycine receptor alpha 2); and GLRA3 (glycine receptor alpha 3).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0070422Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:4327)
DOID:0060696Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:4326)
Molecular_infoCorresponding_CDSF25F8.2
Corresponding_transcriptF25F8.2.1
Other_sequence (24)
Associated_featureWBsf983527
WBsf1009726
WBsf219327
WBsf219328
Experimental_infoRNAi_resultWBRNAi00045520Inferred_automaticallyRNAi_primary
WBRNAi00045519Inferred_automaticallyRNAi_primary
WBRNAi00085185Inferred_automaticallyRNAi_primary
WBRNAi00003451Inferred_automaticallyRNAi_primary
WBRNAi00027617Inferred_automaticallyRNAi_primary
Expr_patternExpr1471
Expr1017586
Expr1030954
Expr1149437
Expr1200289
Expr2012080
Expr2030316
Drives_constructWBCnstr00036840
Construct_productWBCnstr00036840
Microarray_results (18)
Expression_clusterWBPaper00030922:glycosylated_protein
WBPaper00044037:eat-2_upregulated
WBPaper00044578:reduced-humidity_downregulated_microarray
WBPaper00044736:oscillating_dev_expression
WBPaper00045974:NSM_enriched_DSN-treated_RNAseq
WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
WBPaper00048971:daf-16(mgDf50)_upregulated_L1
WBPaper00048988:neuron_expressed
WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
WBPaper00049626:UNC-75_target
WBPaper00049736:daf-2(e1370)_downregulated_15deg-then-25deg(12hr)
WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_100-cell-embryo
WBPaper00050370:dpy-21(e428)_L3_upregulated
WBPaper00050488:20C_vs_25C_regulated_N2_adult
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
WBPaper00050990:hypodermis_enriched
WBPaper00050990:hypodermis_expressed
WBPaper00052884:emb-4(hc60)_downregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00055354:eat-2(ad1116)_downregulated
WBPaper00055354:Psora-Allantoin_downregulated
WBPaper00055354:Rapamycin-Allantoin_downregulated
WBPaper00055354:Rapamycin-Metformin_downregulated
WBPaper00055354:Rifampicin-Allantoin_downregulated
WBPaper00055354:Rifampicin_downregulated
WBPaper00055482:pmt-2(RNAi)_upregulated
WBPaper00055482:Tunicamycin_downregulated
WBPaper00055827:pfd-6(gk493446)_downregulated
WBPaper00055941:atfs-1(et15)_downregulated
WBPaper00055971:nhl-2(ok818)_25C_downregulated
WBPaper00056443:sek-1(km4)_upregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
WBPaper00057041:unc-70(cas983)_downregulated
WBPaper00057154:HeatShock_downregulated_mRNA
WBPaper00058598:mex-1(or286)_upregulated
WBPaper00058598:mex-3(eu149)_upregulated
WBPaper00058598:spn-4(tm291)_upregulated
WBPaper00059605:mut-16(pk710)_upregulated
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00059728:20ug_cholesterol_upregulated
WBPaper00060014:set-2(tm1630)_downregulated
WBPaper00060459:bcat-1(RNAi)_upregulated
WBPaper00060811:L1_vs_adult_upregulated_neural
WBPaper00061340:mu_int_mu_anal
WBPaper00061340:Neuroblast_AIZ_FLP
WBPaper00061340:Neuroblast_URX_CEPDx
WBPaper00061340:RIB
WBPaper00061527:kin-16-C16E9.1
WBPaper00062103:neuron_enriched
WBPaper00062118:neural-HSF-1_upregulated
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062193:skn-1(RNAi)_upregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062345:bortezomib_4h_downregulated_N2
WBPaper00062345:bortezomib_4h_downregulated_zip-1(jy13)
WBPaper00062446:nhr-8(hd117)_downregulated
WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
WBPaper00064716:paraquat_downregulated
WBPaper00065086:N2_N.ferruginous_regulated
WBPaper00065158:AFD_depleted
WBPaper00065835:Day5_vs_Day1_downregulated
WBPaper00065835:Day11_vs_Day1_downregulated
WBPaper00065841:48_0
WBPaper00065841:53_0
WBPaper00065841:67_0
WBPaper00065841:80_0
WBPaper00065841:92_0
WBPaper00065841:97_0
WBPaper00065841:100_0
WBPaper00065841:115_0
WBPaper00065841:116_0
WBPaper00065841:121_0
WBPaper00065841:122_0
WBPaper00065841:130_0
WBPaper00065975:P-body_vs_WholeAnimal_depleted
WBPaper00065993:glp-1(e2141)_upregulated
WBPaper00066232:ash-2(RNAi)_downregulated_WT
cgc4489_group_1
WBPaper00025141:N2_Expressed_Genes
WBPaper00026929:Resveratrol_regulated_daf-16
WBPaper00034661:AgNPs_downregulated
WBPaper00036123:Atrazine_regulated
WBPaper00036286:Pattern_I
WBPaper00037695:WC_5-day
WBPaper00038172:crh-1null_up_regulated
WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
WBPaper00040821:Au-NP_regulated
WBPaper00040858:eQTL_age_regulated_developing
WBPaper00040858:eQTL_regulated_developing
WBPaper00041906:I-3690_vs_OP50_3d
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00042258:DA1877_upregulated_GravidAdult
WBPaper00042274:tbx-2(bx59)_upregulated
WBPaper00045263:nuo-6(qm200)_downregulated
WBPaper00047070:N2_starvation_upregulated
WBPaper00047070:N2_UV_upregulated
WBPaper00047070:xpa-1_UV_upregulated
WBPaper00053236:Starvation_regulated_GR1307
Interaction (17)
Map_infoMapIPosition-0.683729Error0.00921
PositivePositive_cloneF25F8Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point (2)
Pseudo_map_position
Reference (25)
Remarksequence connection from [Vassilatis DK]
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene