WormBase Tree Display for Gene: WBGene00001592

WBGene00001592 SMap: S_parent: Sequence: F25F8
  Identity: Version: 1
    Name: CGC_name: glc-2 Person_evidence: WBPerson32
      Sequence_name: F25F8.2
      Molecular_name: F25F8.2
        F25F8.2.1
        CE09636
      Other_name: avm-2
        GluCl beta Paper_evidence: WBPaper00005494
            WBPaper00044702
            WBPaper00051057
        CELE_F25F8.2 Accession_evidence: NDB BX284601
      Public_name: glc-2
    DB_info: Database: AceView gene 1F454
        WormQTL gene WBGene00001592
        WormFlux gene WBGene00001592
        NDB locus_tag CELE_F25F8.2
        Panther gene CAEEL|WormBase=WBGene00001592|UniProtKB=Q17328
          family PTHR18945
        NCBI gene 172103
        RefSeq protein NM_059069.4
        SwissProt UniProtAcc Q17328
        UniProt_GCRP UniProtAcc Q17328
        OMIM gene 138491
            305990
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:25 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: glc
    Allele (45)
    Strain: WBStrain00028915
      WBStrain00035700
      WBStrain00036012
      WBStrain00035006
    RNASeq_FPKM (74)
    GO_annotation (28)
    Ortholog: WBGene00072196 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00039476 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00145291 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00102369 Pristionchus pacificus From_analysis: OMA
            Inparanoid_8
      WBGene00223839 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g10474 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g2652 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g19036 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g13077 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g10710 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g122 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g15412 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g7811 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g13849 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g17956 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00729.g13746 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-glc-2 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold629.g9780 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp11.Scaffold629.g9781 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_02322.g25969 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_07611 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_000230 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g06044 Oscheius tipulae From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g06045 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g17723 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_10080600 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrI_pilon.g791 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00237099 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00274324 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00262972 Strongyloides ratti From_analysis: WormBase-Compara
      FB:FBgn0024963 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-991117-1 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-010410-2 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-010410-3 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-020402-1 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-020402-2 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-040801-106 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-090407-1 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:4326 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:4327 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:4328 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      MGI:95747 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      MGI:95750 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      MGI:95751 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      MGI:95749 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      MGI:95748 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      RGD:2705 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      RGD:2706 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      RGD:2704 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      RGD:621229 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1564103 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
    Paralog (100)
    Structured_description: Concise_description: glc-2 encodes the beta subunit of a glutamate-gated chloride channel; in vivo, GLC-2 is capable of forming homomeric glutamate-activated channels, as well as heteromeric channels with GLC-1 that can be activated by glutamate and avermectins, antihelmintics that inhibit pharyngeal pumping; as loss of glc-2 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of GLC-2 in development and/or behavior is not yet known; however, GLC-2 expression is generally restricted to the pm4 pharyngeal muscles of larvae and adults, suggesting a role for GLC-2 in regulation of glutamatergic inhibition of pharyngeal pumping. Paper_evidence: WBPaper00002049
            WBPaper00002808
            WBPaper00006139
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables extracellularly glutamate-gated chloride channel activity. Involved in chloride transmembrane transport. Located in plasma membrane. Expressed in pm4. Human ortholog(s) of this gene implicated in hyperekplexia 1 and syndromic X-linked intellectual disability Pilorge type. Is an ortholog of human GLRA1 (glycine receptor alpha 1); GLRA2 (glycine receptor alpha 2); and GLRA3 (glycine receptor alpha 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0070422 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4327)
      DOID:0060696 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4326)
  Molecular_info: Corresponding_CDS: F25F8.2
    Corresponding_transcript: F25F8.2.1
    Other_sequence (24)
    Associated_feature: WBsf983527
      WBsf1009726
      WBsf219327
      WBsf219328
  Experimental_info: RNAi_result: WBRNAi00045520 Inferred_automatically: RNAi_primary
      WBRNAi00045519 Inferred_automatically: RNAi_primary
      WBRNAi00085185 Inferred_automatically: RNAi_primary
      WBRNAi00003451 Inferred_automatically: RNAi_primary
      WBRNAi00027617 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1471
      Expr1017586
      Expr1030954
      Expr1149437
      Expr1200289
      Expr2012080
      Expr2030316
    Drives_construct: WBCnstr00036840
    Construct_product: WBCnstr00036840
    Microarray_results: SMD_F25F8.2
      193732_at
      A_12_P110807
      Aff_F25F8.2
      GPL13394_WBGene00001592
      GPL13914_F25F8.2
      GPL14144_F25F8.2_1074-1133_0.944_1_A
      GPL14144_F25F8.2_1186-1245_0.933_3_B
      GPL14144_F25F8.2_966-1025_0.910_7_C
      GPL19516_CGZ0017938
      GPL21109_F25F8.2
      GPL3518_CE09636
      GPL8304_CE_WBGene00001592_A
      GPL8673_F25F8_2P00029
      GPL8673_F25F8_2P00531
      GPL8673_F25F8_2P01075
      GPL9450_F25F8.2
      cea2.c.02770
    Expression_cluster (108)
    Interaction (17)
  Map_info: Map: I Position: -0.683729 Error: 0.00921
    Positive: Positive_clone: F25F8 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4347
        4424
    Pseudo_map_position
  Reference (25)
  Remark: sequence connection from [Vassilatis DK]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene