gfl-1 encodes an ortholog of human GLIOMA-AMPLIFIED SEQUENCE-41 (GAS41; OMIM:602116, found in increased copy number in low-grade glioma); loss of GLF-1, which is predicted to associate with chromatin, results in potent suppression of the RNA interference (RNAi) mechanism; GLF-1 is also similar to the transcription factors (yeast and human) AF-9 and human ENL, and thus may represent a novel class of transcription factors.
Predicted to enable chromatin binding activity and histone binding activity. Involved in regulatory ncRNA-mediated post-transcriptional gene silencing. Predicted to be located in nucleus. Predicted to be part of NuA4 histone acetyltransferase complex. Is an ortholog of human YEATS4 (YEATS domain containing 4).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.