WormBase Tree Display for Gene: WBGene00001486
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| WBGene00001486 | Evidence | Person_evidence | WBPerson51 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| WBPerson2183 | |||||||||
| SMap | S_parent | Sequence | F59G1 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | frh-1 | Person_evidence | WBPerson730 | |||||
| Sequence_name | F59G1.7 | ||||||||
| Molecular_name | F59G1.7 | ||||||||
| F59G1.7.1 | |||||||||
| CE19476 | |||||||||
| Other_name | CELE_F59G1.7 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | frh-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:24 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | frh | ||||||||
| Allele (19) | |||||||||
| Strain | WBStrain00035730 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (29) | |||||||||
| Contained_in_operon | CEOP2232 | ||||||||
| Ortholog (30) | |||||||||
| Structured_description | Concise_description | frh-1 encodes the C. elegans frataxin ortholog; by homology, FRH-1 is predicted to be a mitochondrial protein required for biogenesis of iron-sulfur clusters, co-factors necessary for proper function of electron transport chain proteins; in C. elegans, loss of frh-1 activity via RNAi results in small body size, pale coloration, reduced motility, decreased pharyngeal pumping and defecation, reduced egg-laying and fertility, hypersensitivity to oxidative stress, and altered adult lifespan; an frh-1::gfp promoter fusion is expressed in neurons, the pharynx, gut, spermatheca and body wall muscle; in the pharynx, FRH-1 localizes to the mitochondria. | Paper_evidence | WBPaper00025031 | |||||
| WBPaper00028282 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 17 Aug 2009 00:00:00 | ||||||||
| Automated_description | Predicted to enable several functions, including 2 iron, 2 sulfur cluster binding activity; ferroxidase activity; and iron ion binding activity. Involved in determination of adult lifespan; response to hydrogen peroxide; and response to superoxide. Located in mitochondrion. Expressed in amphid neurons; body wall musculature; pharyngeal muscle cell; and spermatheca. Used to study Friedreich ataxia. Human ortholog(s) of this gene implicated in Friedreich ataxia 1 and type 2 diabetes mellitus. Is an ortholog of human FXN (frataxin). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:12705 | Homo sapiens | Paper_evidence | WBPaper00028282 | ||||
| WBPaper00041842 | |||||||||
| Accession_evidence | OMIM | 229300 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 02 Oct 2013 00:00:00 | ||||||||
| Potential_model | DOID:3068 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3951) | |||||
| DOID:0111218 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3951) | ||||||
| DOID:9352 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3951) | ||||||
| DOID:12705 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3951) | ||||||
| Disease_relevance | In humans, deficiency of the mitochondrial protein frataxin (FXN) causes Friedreich ataxia (FRDA), an autosomal recessive neurological disorder. | Homo sapiens | Accession_evidence | OMIM | 229300 | ||||
| 606829 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Models_disease_in_annotation | WBDOannot00000235 | ||||||||
| WBDOannot00000628 | |||||||||
| Molecular_info | Corresponding_CDS | F59G1.7 | |||||||
| Corresponding_transcript | F59G1.7.1 | ||||||||
| Other_sequence (12) | |||||||||
| Associated_feature | WBsf657644 | ||||||||
| WBsf221365 | |||||||||
| Experimental_info | RNAi_result (71) | ||||||||
| Expr_pattern | Expr4755 | ||||||||
| Expr4756 | |||||||||
| Expr4757 | |||||||||
| Expr1028907 | |||||||||
| Expr1030887 | |||||||||
| Expr1152978 | |||||||||
| Expr2011879 | |||||||||
| Expr2030117 | |||||||||
| Drives_construct | WBCnstr00012222 | ||||||||
| WBCnstr00012223 | |||||||||
| WBCnstr00012224 | |||||||||
| Construct_product | WBCnstr00012222 | ||||||||
| WBCnstr00012223 | |||||||||
| WBCnstr00012224 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (87) | |||||||||
| Interaction (115) | |||||||||
| Map_info | Map | II | Position | -0.852617 | Error | 0.000682 | |||
| Positive | Positive_clone | F59G1 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4326 | |||||||
| Pseudo_map_position | |||||||||
| Reference (22) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
