fbl-1 encodes proteins orthologous to the vertebrate basement membrane protein fibulin; fbl-1 activity is essential for gonad and body morphology, as well as for reproduction; fbl-1 interacts genetically with gon-1 and mig-17, which encode ADAMTS metalloproteases essential for gonad development; the FBL-1C isoform is expressed in anterior and posterior intestinal cells and localizes to the gonad and pharyngeal basement membranes; the FBL-1D isoform is expressed in some head and tail body wall muscle cells.
An extracellular matrix structural constituent. Involved in extracellular matrix organization; positive regulation of locomotion; and protein localization. Located in basement membrane. Expressed in ALM; GLR; basal lamina; hyp7 syncytium; and nerve ring. Is an ortholog of human FBLN1 (fibulin 1).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.