WormBase Tree Display for Gene: WBGene00001358
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| WBGene00001358 | SMap | S_parent | Sequence | F22B5 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | evl-20 | Person_evidence | WBPerson220 | |||||
| Sequence_name | F22B5.1 | ||||||||
| Molecular_name | F22B5.1 | ||||||||
| F22B5.1.1 | |||||||||
| CE27425 | |||||||||
| Other_name | arl-5 | ||||||||
| arl-2 | |||||||||
| ARF/2 | |||||||||
| arf-2 | |||||||||
| CELE_F22B5.1 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | evl-20 | ||||||||
| DB_info | Database | AceView | gene | 2I735 | |||||
| WormQTL | gene | WBGene00001358 | |||||||
| WormFlux | gene | WBGene00001358 | |||||||
| NDB | locus_tag | CELE_F22B5.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00001358|UniProtKB=Q19705 | |||||||
| family | PTHR45697 | ||||||||
| NCBI | gene | 191632 | |||||||
| RefSeq | protein | NM_063378.4 | |||||||
| SwissProt | UniProtAcc | Q19705 | |||||||
| TREEFAM | TREEFAM_ID | TF105462 | |||||||
| UniProt_GCRP | UniProtAcc | Q19705 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:24 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | evl | ||||||||
| Allele (13) | |||||||||
| Legacy_information | [C.elegansII] ar103 : everted vulva, sterile; no L4 vulval invagination; abnormal uterus; distal germline abnormal, no sperm or oocytes. NA1. [Seydoux et al., 1993] | ||||||||
| [I Antoshechkin] Homozygous animals from heterozygous mothers are sterile and have abnormally everted vulva. RNAi results in embryonic lethality. | |||||||||
| Strain | WBStrain00036522 | ||||||||
| WBStrain00007993 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (28) | |||||||||
| Contained_in_operon | CEOP2344 | ||||||||
| Ortholog (39) | |||||||||
| Paralog (14) | |||||||||
| Structured_description | Concise_description | evl-20 encodes a functional ortholog of human ADP-ribosylation factor-like protein 2 (ARL2; OMIM:601175), with evl-20(ar103) mutants being rescued by transgenic human ARL2 but not ARL1 or ARL3-7; EVL-20 is required for cortical microtubule formation during cytokinesis and morphogenesis; EVL-20 is required for vulval, gonadal, and male tail development, as well as for embryonic mitosis, hypodermal enclosure, and elongation; EVL-20 is expressed in migrating hypodermal embryonic cells, larval vulval and somatic gonad cells, larval and adult neurons, and adult male proctodeal cells, being subcellularly associated with both the cell cortex and astral microtubules. | Paper_evidence | WBPaper00005256 | |||||
| WBPaper00012794 | |||||||||
| WBPaper00012812 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable GTP binding activity. Involved in several processes, including cortical microtubule organization; female genitalia development; and mitotic cytokinesis. Located in cytoplasm; microtubule cytoskeleton; and plasma membrane. Expressed in several structures, including P3.p hermaphrodite; hermaphrodite gonad; hyp12; proctodeum; and vulval cell. Is an ortholog of human ARL2 (ADP ribosylation factor like GTPase 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F22B5.1 | |||||||
| Corresponding_CDS_history | F22B5.1:wp49 | ||||||||
| Corresponding_transcript | F22B5.1.1 | ||||||||
| Other_sequence (23) | |||||||||
| Experimental_info | RNAi_result (12) | ||||||||
| Expr_pattern | Expr1899 | ||||||||
| Expr1900 | |||||||||
| Expr13313 | |||||||||
| Expr1021116 | |||||||||
| Expr1030822 | |||||||||
| Expr1149205 | |||||||||
| Expr2011389 | |||||||||
| Expr2029625 | |||||||||
| Drives_construct | WBCnstr00010510 | ||||||||
| WBCnstr00019843 | |||||||||
| WBCnstr00036989 | |||||||||
| Construct_product | WBCnstr00019843 | ||||||||
| WBCnstr00036989 | |||||||||
| Antibody | WBAntibody00000508 | ||||||||
| Microarray_results (17) | |||||||||
| Expression_cluster (83) | |||||||||
| SAGE_tag | SAGE:gttatgcgat | Strand | Sense | ||||||
| Unambiguously_mapped | |||||||||
| SAGE:tcattgcttggaccagt | Strand | Antisense | |||||||
| SAGE:tcattgcttg | Strand | Antisense | |||||||
| SAGE:gttatgcgatgatgttg | Strand | Sense | |||||||
| Unambiguously_mapped | |||||||||
| Interaction (23) | |||||||||
| Map_info | Map | II | Position | 0.777826 | Error | 0.00361 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | F22B5 | Person_evidence | WBPerson22 | |||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| NM#ARFB | |||||||||
| Mapping_data | Multi_point | 3465 | |||||||
| 4005 | |||||||||
| 4006 | |||||||||
| 4007 | |||||||||
| 4696 | |||||||||
| Reference (14) | |||||||||
| Remark | This gene on II was re-named to arl-5, but arl-5 has now been assigned to a different CDS. | ||||||||
| [C.elegansII] NMK. pka arf-2. Encodes predicted 184 aa ARL2-like protein. [MQ] | |||||||||
| The arf-2 was merged into the evl-20 gene following advice from J. Hodgkin. krb 28/02/02 | |||||||||
| Method | Gene |
