WormBase Tree Display for Gene: WBGene00001224

WBGene00001224 SMap: S_parent: Sequence: ZK1248
  Identity: Version: 1
    Name: CGC_name: ehs-1 Person_evidence: WBPerson52
      Sequence_name: ZK1248.3
      Molecular_name: ZK1248.3a
        ZK1248.3a.1
        CE44947
        ZK1248.3b
      Other_name: CELE_ZK1248.3 Accession_evidence: NDB BX284602
      Public_name: ehs-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:23 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ehs
    Allele (41)
    Strain: WBStrain00003367
      WBStrain00029058
      WBStrain00051861
    RNASeq_FPKM (74)
    GO_annotation (13)
    Ortholog: WBGene00057280 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00025548 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00155900 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00097714 Pristionchus pacificus From_analysis: OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00192835 Caenorhabditis brenneri From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00130751 Caenorhabditis japonica From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00227905 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g12574 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g13640 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g5512 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g15209 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g12323 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g22118 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g9699 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g21448 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g15160 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g27166 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g8579 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g7049 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cni-ehs-1 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold630.g19418 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00875.g16354 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_04416 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_006126 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g09138 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g17828 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_20117000 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrII_pilon.g4620 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00247071 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00285237 Trichuris muris From_analysis: WormBase-Compara
      SGD:S000000143 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      SGD:S000005028 Saccharomyces cerevisiae From_analysis: Hieranoid
            OrthoFinder
            Panther
      FB:FBgn0035060 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-060503-274 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-081104-264 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-140213-1 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      HGNC:3419 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:24634 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:104583 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:104582 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1305550 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1565708 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
    Paralog: WBGene00004373 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00012696 Caenorhabditis elegans From_analysis: Panther
      WBGene00006405 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: ehs-1 encodes an ortholog of mammalian Eps15; EHS-1 functions as an endocytic adaptor protein to regulate cargo sorting through the endolysosomal system; EHS-1 is also required, together with ITSN-1, for synaptic vesicle recycling and hence, regulation of neurotransmission; immunofluorescence staining of embryos indicates that EHS-1 localizes to the plasma membrane. Paper_evidence: WBPaper00004812
            WBPaper00042550
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 19 Sep 2013 00:00:00
      Automated_description: Involved in chemical synaptic transmission and synaptic vesicle endocytosis. Located in axon; plasma membrane; and synapse. Expressed in epithelial cell; intestine; muscle cell; and nervous system. Is an ortholog of human EPS15 (epidermal growth factor receptor pathway substrate 15) and EPS15L1 (epidermal growth factor receptor pathway substrate 15 like 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: ZK1248.3a
    Corresponding_CDS_history: ZK1248.3b:wp185
      ZK1248.3b:wp261
    Corresponding_transcript: ZK1248.3b
      ZK1248.3a.1
    Other_sequence (20)
    Associated_feature: WBsf644227
      WBsf654841
      WBsf657628
      WBsf987967
      WBsf987968
      WBsf1012267
      WBsf221347
  Experimental_info: RNAi_result: WBRNAi00038185 Inferred_automatically: RNAi_primary
      WBRNAi00098749 Inferred_automatically: RNAi_primary
      WBRNAi00098750 Inferred_automatically: RNAi_primary
      WBRNAi00059191 Inferred_automatically: RNAi_primary
      WBRNAi00062548 Inferred_automatically: RNAi_primary
      WBRNAi00098748 Inferred_automatically: RNAi_primary
      WBRNAi00098503 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram1017
      Expr1647
      Expr15238
      Expr15239
      Expr1024595
      Expr1030772
      Expr1162610
      Expr2011239
      Expr2029475
    Drives_construct: WBCnstr00003838
      WBCnstr00021034
      WBCnstr00037028
      WBCnstr00041790
    Construct_product: WBCnstr00037028
      WBCnstr00042134
      WBCnstr00042135
    Antibody: WBAntibody00000394
      WBAntibody00002466
    Microarray_results (31)
    Expression_cluster (109)
    Interaction (184)
  Map_info: Map: II Position: -0.914871 Error: 0.00257
    Positive: Positive_clone: ZK1248 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4278
        5321
        5611
    Pseudo_map_position
  Reference (17)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene