WormBase Tree Display for Gene: WBGene00001198
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| WBGene00001198 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | egl-32 | Person_evidence | WBPerson268 | |||||
| Public_name | egl-32 | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:23 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Split_into | WBGene00044684 | ||||||||
| Status | Live | ||||||||
| Gene_info | Gene_class | egl | |||||||
| Reference_allele | WBVar00089289 | ||||||||
| Allele | WBVar00089289 | Inferred_automatically | From strain object: MT155 | ||||||
| From strain object: MT2214 | |||||||||
| From strain object: MT2215 | |||||||||
| Legacy_information | n155ts : moderate bloating Type E partially temperature-sensitive; suppressible by daf-3. ES2 (adult). ME3. NA1. | ||||||||
| [C.elegansII] n155ts : moderate bloating, variable drug response;partially temperature-sensitive; suppressible by daf-3. ES2 (adult). ME3 (some males have abnormal somatic gonads, some have abnormal or feminized germ lines). NA1. [Trent et al. 1983; MT] | |||||||||
| Strain | WBStrain00026707 | ||||||||
| WBStrain00026945 | |||||||||
| WBStrain00026946 | |||||||||
| GO_annotation | 00106081 | ||||||||
| 00106082 | |||||||||
| 00106083 | |||||||||
| 00106084 | |||||||||
| 00106085 | |||||||||
| Structured_description | Concise_description | egl-32 was initially identified in screens for mutations that result in egg-laying defects; egl-32 is characterized by a single, temperature-sensitive mutation that results in increased egg retention and a reduced rate of egg laying when compared to wild-type hermaphrodites; egl-32 mutant hermaphrodites also display a small, but statistically significant decrease in ovulation rate; egl-32 is required for normal chemosensory responses mediated by the AWC neurons, and to a lesser extent for responses to odorants sensed by the AWA neurons; genetic and phenotypic analyses suggest that egl-32 activity is required during the L4 larval stage and in sperm to promote egg laying; egl-32 defects in egg-laying and chemosensation are suppressed by mutations in daf-3 and daf-5, which encode TGF-beta pathway components. | Paper_evidence | WBPaper00000635 | |||||
| WBPaper00004310 | |||||||||
| WBPaper00029335 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson1843 | |||||||||
| Date_last_updated | 24 Jul 2008 00:00:00 | ||||||||
| Automated_description | Acts upstream of or within egg-laying behavior; sensory perception of chemical stimulus; and transforming growth factor beta receptor signaling pathway. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Experimental_info | Antibody | WBAntibody00000252 | |||||||
| Interaction (15) | |||||||||
| WBProcess | WBbiopr:00000025 | ||||||||
| Map_info | Map | I | Position | 3.32116 | Error | 0.007293 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | nDf29 | |||||||
| mnDf111 | |||||||||
| nDf23 | |||||||||
| Positive_clone | T08G11 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| Negative | Outside_rearr | qDf9 | |||||||
| Mapping_data | Multi_point | 639 | |||||||
| 640 | |||||||||
| 734 | |||||||||
| Pos_neg_data | 10248 | ||||||||
| 10249 | |||||||||
| 10250 | |||||||||
| 10251 | |||||||||
| Reference (22) | |||||||||
| Remark | egl-32 was previously connected to T08G11.2 based on rescue and RNAi phenotypes. Subsequently, no mutation in T08G11.2 from egl-32 mutants have been found thus egl-32 and T08G11.2 may be interacting loci | Person_evidence | WBPerson551 | ||||||
| Method | Gene |
