WormBase Tree Display for Gene: WBGene00001189

WBGene00001189 SMap: S_parent: Sequence: F01D4
  Identity: Version: 1
    Name: CGC_name: egl-21 Person_evidence: WBPerson268
      Sequence_name: F01D4.4
      Molecular_name: F01D4.4
        F01D4.4.1
        CE09156
      Other_name: CELE_F01D4.4 Accession_evidence: NDB BX284604
      Public_name: egl-21
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:23 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: egl
    Reference_allele: WBVar00089624
    Allele (43)
    Legacy_information: n611ts : transient bloating at 25x Type E partially temperature sensitive uncoordinated weak coiler. ES2 (adult). NA3 (n476 n576).
      [C.elegansII] n611ts : transient bloating at 25C, variable drug response; partially temperature sensitive;uncoordinated weak coiler; abnormal 5-HT signalling. ES2 (adult). ME2. OA2: n476, n576. [Trent et al. 1983; KP; MT]
    Strain: WBStrain00023630
      WBStrain00026777
      WBStrain00026813
      WBStrain00026827
      WBStrain00026874
    RNASeq_FPKM (74)
    GO_annotation (41)
    Ortholog (52)
    Paralog: WBGene00012073 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00019074 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: egl-21 encodes a putative carboxypeptidase (whose homologs include humanenkephalin convertase/carboxypeptidase E); EGL-21 is expressedthroughout the nervous system; EGL-21 is required for normal synthesisof FMRFamide-like (FLP) and neuropeptide-like (NLP) peptides, and for normal egg-laying, locomotion, and defecation; EGL-21 promotes acetylcholine release at neuromuscular junctions; egl-21 mutant defects resemble those seen for mutants of theproprotein convertase type 2 EGL-3. Paper_evidence: WBPaper00005776
            WBPaper00006103
            WBPaper00030763
          Curator_confirmed: WBPerson48
            WBPerson1843
            WBPerson567
          Date_last_updated: 10 Mar 2008 00:00:00
      Automated_description: Enables carboxypeptidase activity. Involved in several processes, including cellular response to carbon dioxide; regulation of multicellular organismal process; and regulation of neurotransmitter levels. Located in axon; cytoplasmic vesicle; and neuronal cell body. Expressed in nervous system and uv1. Human ortholog(s) of this gene implicated in carboxypeptidase N deficiency; morbid obesity; and type 2 diabetes mellitus. Is an ortholog of human CPE (carboxypeptidase E). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0111583 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2312)
      DOID:9970 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2303)
      DOID:9352 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2303)
      DOID:11981 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2303)
  Molecular_info: Corresponding_CDS: F01D4.4
    Corresponding_transcript: F01D4.4.1
    Other_sequence (140)
    Associated_feature: WBsf652133
      WBsf668250
      WBsf230743
      WBsf230744
      WBsf230745
  Experimental_info: RNAi_result (16)
    Expr_pattern: Expr2378
      Expr15246
      Expr1028609
      Expr1030761
      Expr1147706
      Expr2011213
      Expr2029449
    Drives_construct: WBCnstr00010801
      WBCnstr00037040
    Construct_product: WBCnstr00010801
      WBCnstr00021862
      WBCnstr00037040
    Antibody: WBAntibody00002570
    Microarray_results (24)
    Expression_cluster (341)
    Interaction: WBInteraction000004043
      WBInteraction000029698
      WBInteraction000030450
      WBInteraction000108811
      WBInteraction000111961
      WBInteraction000122020
      WBInteraction000124414
      WBInteraction000138462
      WBInteraction000150837
      WBInteraction000151182
      WBInteraction000152041
      WBInteraction000157628
      WBInteraction000170501
      WBInteraction000172692
      WBInteraction000178046
      WBInteraction000183862
      WBInteraction000184026
      WBInteraction000206986
      WBInteraction000209272
      WBInteraction000214096
      WBInteraction000215932
      WBInteraction000216726
      WBInteraction000217401
      WBInteraction000222203
      WBInteraction000222388
      WBInteraction000222979
      WBInteraction000224593
      WBInteraction000228792
      WBInteraction000229733
      WBInteraction000240244
      WBInteraction000250692
      WBInteraction000253513
      WBInteraction000254245
      WBInteraction000254555
      WBInteraction000259761
      WBInteraction000262523
      WBInteraction000264668
      WBInteraction000267176
      WBInteraction000267781
      WBInteraction000270059
      WBInteraction000280337
      WBInteraction000302477
      WBInteraction000302527
      WBInteraction000303930
      WBInteraction000313069
      WBInteraction000314288
      WBInteraction000319461
      WBInteraction000334661
      WBInteraction000335024
      WBInteraction000336281
      WBInteraction000339162
      WBInteraction000344652
      WBInteraction000345582
      WBInteraction000346656
      WBInteraction000348726
      WBInteraction000349936
      WBInteraction000352309
      WBInteraction000355805
      WBInteraction000359361
      WBInteraction000360286
      WBInteraction000366302
      WBInteraction000383303
      WBInteraction000384053
      WBInteraction000386289
      WBInteraction000386941
      WBInteraction000388923
      WBInteraction000396192
      WBInteraction000398259
      WBInteraction000399014
      WBInteraction000400155
      WBInteraction000401932
      WBInteraction000406265
      WBInteraction000406955
      WBInteraction000411626
      WBInteraction000414786
      WBInteraction000416690
      WBInteraction000420722
      WBInteraction000422707
      WBInteraction000428486
      WBInteraction000436324
      WBInteraction000437513
      WBInteraction000447083
      WBInteraction000448077
      WBInteraction000450933
      WBInteraction000452425
      WBInteraction000452502
      WBInteraction000459026
      WBInteraction000500517
      WBInteraction000501850
      WBInteraction000512383
      WBInteraction000512384
      WBInteraction000517215
      WBInteraction000517216
      WBInteraction000517217
    Anatomy_function: WBbtf0207
      WBbtf0208
      WBbtf0211
  Map_info: Map: IV Position: 4.60123 Error: 0.002141
    Positive: Positive_clone: F01D4 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 626
        1829
        3240
  Reference (47)
  Method: Gene