WormBase Tree Display for Gene: WBGene00001189
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| WBGene00001189 | SMap | S_parent | Sequence | F01D4 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | egl-21 | Person_evidence | WBPerson268 | |||||
| Sequence_name | F01D4.4 | ||||||||
| Molecular_name | F01D4.4 | ||||||||
| F01D4.4.1 | |||||||||
| CE09156 | |||||||||
| Other_name | CELE_F01D4.4 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | egl-21 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:23 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | egl | ||||||||
| Reference_allele | WBVar00089624 | ||||||||
| Allele (43) | |||||||||
| Legacy_information | n611ts : transient bloating at 25x Type E partially temperature sensitive uncoordinated weak coiler. ES2 (adult). NA3 (n476 n576). | ||||||||
| [C.elegansII] n611ts : transient bloating at 25C, variable drug response; partially temperature sensitive;uncoordinated weak coiler; abnormal 5-HT signalling. ES2 (adult). ME2. OA2: n476, n576. [Trent et al. 1983; KP; MT] | |||||||||
| Strain | WBStrain00023630 | ||||||||
| WBStrain00026777 | |||||||||
| WBStrain00026813 | |||||||||
| WBStrain00026827 | |||||||||
| WBStrain00026874 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (41) | |||||||||
| Ortholog (52) | |||||||||
| Paralog | WBGene00012073 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00019074 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | egl-21 encodes a putative carboxypeptidase (whose homologs include humanenkephalin convertase/carboxypeptidase E); EGL-21 is expressedthroughout the nervous system; EGL-21 is required for normal synthesisof FMRFamide-like (FLP) and neuropeptide-like (NLP) peptides, and for normal egg-laying, locomotion, and defecation; EGL-21 promotes acetylcholine release at neuromuscular junctions; egl-21 mutant defects resemble those seen for mutants of theproprotein convertase type 2 EGL-3. | Paper_evidence | WBPaper00005776 | |||||
| WBPaper00006103 | |||||||||
| WBPaper00030763 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson1843 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 10 Mar 2008 00:00:00 | ||||||||
| Automated_description | Enables carboxypeptidase activity. Involved in several processes, including cellular response to carbon dioxide; regulation of multicellular organismal process; and regulation of neurotransmitter levels. Located in axon; cytoplasmic vesicle; and neuronal cell body. Expressed in nervous system and uv1. Human ortholog(s) of this gene implicated in carboxypeptidase N deficiency; morbid obesity; and type 2 diabetes mellitus. Is an ortholog of human CPE (carboxypeptidase E). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0111583 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2312) | ||||
| DOID:9970 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2303) | ||||||
| DOID:9352 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2303) | ||||||
| DOID:11981 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2303) | ||||||
| Molecular_info | Corresponding_CDS | F01D4.4 | |||||||
| Corresponding_transcript | F01D4.4.1 | ||||||||
| Other_sequence (140) | |||||||||
| Associated_feature | WBsf652133 | ||||||||
| WBsf668250 | |||||||||
| WBsf230743 | |||||||||
| WBsf230744 | |||||||||
| WBsf230745 | |||||||||
| Experimental_info | RNAi_result (16) | ||||||||
| Expr_pattern | Expr2378 | ||||||||
| Expr15246 | |||||||||
| Expr1028609 | |||||||||
| Expr1030761 | |||||||||
| Expr1147706 | |||||||||
| Expr2011213 | |||||||||
| Expr2029449 | |||||||||
| Drives_construct | WBCnstr00010801 | ||||||||
| WBCnstr00037040 | |||||||||
| Construct_product | WBCnstr00010801 | ||||||||
| WBCnstr00021862 | |||||||||
| WBCnstr00037040 | |||||||||
| Antibody | WBAntibody00002570 | ||||||||
| Microarray_results (24) | |||||||||
| Expression_cluster (341) | |||||||||
| Interaction (94) | |||||||||
| Anatomy_function | WBbtf0207 | ||||||||
| WBbtf0208 | |||||||||
| WBbtf0211 | |||||||||
| Map_info | Map | IV | Position | 4.60123 | Error | 0.002141 | |||
| Positive | Positive_clone | F01D4 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 626 | |||||||
| 1829 | |||||||||
| 3240 | |||||||||
| Reference (47) | |||||||||
| Method | Gene |
