WormBase Tree Display for Gene: WBGene00001127
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| WBGene00001127 | SMap | S_parent | Sequence | CHROMOSOME_X | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | dyf-11 | Person_evidence | WBPerson252 | |||||
| WBPerson41163 | |||||||||
| Sequence_name | C02H7.1 | ||||||||
| Molecular_name | C02H7.1 | ||||||||
| C02H7.1.1 | |||||||||
| CE06757 | |||||||||
| Other_name | ift-54 | Person_evidence | WBPerson41163 | ||||||
| CELE_C02H7.1 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | dyf-11 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:23 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 28 Nov 2007 17:00:11 | WBPerson2970 | Event | Acquires_merge | WBGene00015363 | ||||
| Name_change | Sequence_name | C02H7.1 | |||||||
| 3 | 05 May 2023 12:43:53 | WBPerson51134 | Name_change | CGC_name | dyf-11 | ||||
| Other_name | ift-54 | ||||||||
| Acquires_merge | WBGene00015363 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | dyf | ||||||||
| Allele (54) | |||||||||
| Legacy_information | [Herman RK] Defective in dye (FITC or DiO) filling of amphid and phasmid neurons. Animals slightly short. Chemotaxis defective. ME3. | ||||||||
| [C.elegansII] mn392 : defective in dye (FITC or DiO) filling of amphid and phasmid neurons. Animals slightly short. Chemotaxis defective. ME3. NA1. [Starich et al. 1995] | |||||||||
| Complementation_data | [Herman RK] dyf-11(mn392) complements che-2(e1033), che-2(mn395) and daf-3(e1376) with respect to dye filling. | ||||||||
| Strain | WBStrain00002488 | ||||||||
| WBStrain00022695 | |||||||||
| WBStrain00034382 | |||||||||
| WBStrain00036634 | |||||||||
| WBStrain00037125 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (21) | |||||||||
| Ortholog (36) | |||||||||
| Structured_description | Concise_description | dyf-11 encodes a conserved protein that is orthologous to mammalian IFT54 (MIP-T3, Traf3ip1) and that contains a lysine-rich region and a C-terminal coiled-coil domain present in a number of intraflagellar transport complex B (IFT-B) proteins; DYF-11 activity is required continuously in sensory neurons for formation of medial and distal ciliary segments and thus, for normal sensory cilium morphology and function and chemotaxis; DYF-11 physically interacts with DYF-19, the C. elegans FBF1 (Fas(TNFRSF6)-binding factor 1) ortholog that localizes to ciliary transition fibers; a dyf-11::gfp promoter fusion is expressed in all ciliated sensory neurons as well as in the AQR, PQR, ADE, and PDR neurons; a DYF-11::GFP protein fusion is detected throughout the cilium and localizes to IFT-B subcomplexes in a manner consistent with an early role in IFT-B subcomplex assembly; dyf-11 expression in ciliated neurons is dependent upon the presence of the DAF-19 RFX transcription factor. | Paper_evidence | WBPaper00002087 | |||||
| WBPaper00003954 | |||||||||
| WBPaper00029131 | |||||||||
| WBPaper00031375 | |||||||||
| WBPaper00031483 | |||||||||
| WBPaper00044470 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 05 Dec 2013 00:00:00 | ||||||||
| Automated_description | Predicted to enable microtubule binding activity. Involved in several processes, including cilium organization; dauer entry; and hyperosmotic response. Located in axoneme and ciliary basal body. Part of intraciliary transport particle B. Expressed in ciliated neurons and sensory neurons. Human ortholog(s) of this gene implicated in Senior-Loken syndrome. Is an ortholog of human TRAF3IP1 (TRAF3 interacting protein 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0050576 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17861) | ||||
| Molecular_info | Corresponding_CDS | C02H7.1 | |||||||
| Corresponding_transcript | C02H7.1.1 | ||||||||
| Other_sequence | ASC30593_1 | ||||||||
| JI180288.1 | |||||||||
| FE917477.1 | |||||||||
| Associated_feature | WBsf647793 | ||||||||
| WBsf1003856 | |||||||||
| WBsf1003857 | |||||||||
| WBsf1022168 | |||||||||
| WBsf235278 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00028367 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00039465 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (15) | |||||||||
| Drives_construct | WBCnstr00003078 | ||||||||
| WBCnstr00004533 | |||||||||
| WBCnstr00006568 | |||||||||
| WBCnstr00011192 | |||||||||
| WBCnstr00012140 | |||||||||
| WBCnstr00013099 | |||||||||
| WBCnstr00013128 | |||||||||
| WBCnstr00013161 | |||||||||
| WBCnstr00013206 | |||||||||
| Construct_product | WBCnstr00006568 | ||||||||
| WBCnstr00011192 | |||||||||
| WBCnstr00013099 | |||||||||
| WBCnstr00013128 | |||||||||
| WBCnstr00013206 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (153) | |||||||||
| Interaction (30) | |||||||||
| Map_info | Map | X | Position | -19.5014 | Error | 0.001047 | |||
| Positive | Positive_clone | C02H7 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 3080 | |||||||
| 3081 | |||||||||
| 3082 | |||||||||
| 3083 | |||||||||
| Reference (33) | |||||||||
| Method | Gene |
