dyb-1 encodes a homolog of mammalian alpha-dystrobrevin (DTNA); DYB-1 physically interacts with DYS-1/dystrophin in vitro and CTN-1/alpha-catulinand and DYS-1/dystrophin in vivo.
Enables acetylcholine transmembrane transporter activity and cytoskeletal protein binding activity. Involved in several processes, including muscle cell cellular homeostasis; positive regulation of cholinergic synaptic transmission; and sarcomere organization. Located in plasma membrane. Part of dystrobrevin complex. Expressed in body wall musculature; non-striated muscle; somatic nervous system; and tail neurons. Used to study Duchenne muscular dystrophy. Human ortholog(s) of this gene implicated in left ventricular noncompaction. Is an ortholog of human DTNA (dystrobrevin alpha).