WormBase Tree Display for Gene: WBGene00001061
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| WBGene00001061 | SMap | S_parent | Sequence | T23G7 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | dpl-1 | Person_evidence | WBPerson268 | |||||
| Sequence_name | T23G7.1 | ||||||||
| Molecular_name | T23G7.1 | ||||||||
| T23G7.1.1 | |||||||||
| CE21197 | |||||||||
| T23G7.1.2 | |||||||||
| Other_name | mex-4 | CGC_data_submission | |||||||
| szy-10 | Paper_evidence | WBPaper00049084 | |||||||
| Person_evidence | WBPerson728 | ||||||||
| CELE_T23G7.1 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | dpl-1 | ||||||||
| DB_info | Database | AceView | gene | 2J461 | |||||
| WormQTL | gene | WBGene00001061 | |||||||
| WormFlux | gene | WBGene00001061 | |||||||
| NDB | locus_tag | CELE_T23G7.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00001061|UniProtKB=Q22703 | |||||||
| family | PTHR12548 | ||||||||
| NCBI | gene | 174458 | |||||||
| RefSeq | protein | NM_063556.8 | |||||||
| SwissProt | UniProtAcc | Q22703 | |||||||
| TREEFAM | TREEFAM_ID | TF314396 | |||||||
| UniProt_GCRP | UniProtAcc | Q22703 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:22 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 22 Jan 2016 09:01:40 | WBPerson2970 | Event | Acquires_merge | WBGene00077738 | ||||
| Acquires_merge | WBGene00077738 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | dpl | ||||||||
| Allele (41) | |||||||||
| Strain | WBStrain00027348 | ||||||||
| WBStrain00027370 | |||||||||
| WBStrain00027388 | |||||||||
| WBStrain00029184 | |||||||||
| WBStrain00036662 | |||||||||
| WBStrain00030007 | |||||||||
| WBStrain00022495 | |||||||||
| RNASeq_FPKM (73) | |||||||||
| GO_annotation (24) | |||||||||
| Ortholog (41) | |||||||||
| Structured_description | Concise_description | dpl-1 encodes the C. elegans ortholog of mammalian DP, the E2F-heterodimerization partner; dpl-1 is a class B synMuv gene whose activity is required for oogenesis as well as embryonic asymmetry and vulval development; in addition, dpl-1 acts with a subset of class B synMuv genes and the MCD-1 zinc-finger protein to promote the killing process during programmed cell death; DPL-1 is a nuclear protein that is widely expressed throughout development in both somatic and germ cell lineages. | Paper_evidence | WBPaper00004589 | |||||
| WBPaper00004634 | |||||||||
| WBPaper00004635 | |||||||||
| WBPaper00027758 | |||||||||
| WBPaper00029005 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 17 Jul 2007 00:00:00 | ||||||||
| Automated_description | Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including negative regulation of Ras protein signal transduction; negative regulation of vulval development; and regulation of cell cycle. Located in nucleus. Expressed in germ line; gonad; and hyp7 syncytium. Human ortholog(s) of this gene implicated in mismatch repair cancer syndrome. Is an ortholog of human TFDP1 (transcription factor Dp-1); TFDP2 (transcription factor Dp-2); and TFDP3 (transcription factor Dp family member 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0112182 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11749) | ||||
| Molecular_info | Corresponding_CDS | T23G7.1 | |||||||
| Corresponding_transcript | T23G7.1.1 | ||||||||
| T23G7.1.2 | |||||||||
| Other_sequence (28) | |||||||||
| Associated_feature | WBsf644551 | ||||||||
| WBsf658067 | |||||||||
| WBsf978804 | |||||||||
| WBsf221854 | |||||||||
| Gene_product_binds (11248) | |||||||||
| Transcription_factor | WBTranscriptionFactor000703 | ||||||||
| Experimental_info | RNAi_result (19) | ||||||||
| Expr_pattern | Expr882 | ||||||||
| Expr4030 | |||||||||
| Expr10271 | |||||||||
| Expr1025828 | |||||||||
| Expr1030671 | |||||||||
| Expr1157526 | |||||||||
| Expr1200005 | |||||||||
| Expr1200124 | |||||||||
| Expr2011050 | |||||||||
| Expr2029287 | |||||||||
| Drives_construct | WBCnstr00015219 | ||||||||
| WBCnstr00017290 | |||||||||
| WBCnstr00037109 | |||||||||
| Construct_product | WBCnstr00016770 | ||||||||
| WBCnstr00017288 | |||||||||
| WBCnstr00017290 | |||||||||
| WBCnstr00017297 | |||||||||
| WBCnstr00037109 | |||||||||
| Regulate_expr_cluster | WBPaper00027758:Group_I | ||||||||
| WBPaper00027758:Group_II | |||||||||
| WBPaper00027758:Group_III | |||||||||
| WBPaper00027758:Regulated_genes_not_in_group | |||||||||
| WBPaper00062056:dpl-1(n2994)_downregulated | |||||||||
| WBPaper00062056:dpl-1(n2994)_upregulated | |||||||||
| Antibody | WBAntibody00000357 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (124) | |||||||||
| Interaction (190) | |||||||||
| Product_binds_matrix | WBPmat00005537 | ||||||||
| WBPmat00005538 | |||||||||
| WBPmat00005539 | |||||||||
| WBPmat00005540 | |||||||||
| WBPmat00005541 | |||||||||
| WBPmat00005542 | |||||||||
| WBPmat00005543 | |||||||||
| WBPmat00005544 | |||||||||
| WBPmat00005545 | |||||||||
| Map_info | Map | II | Position | 1.08207 | Error | 0.005888 | |||
| Positive | Positive_clone | T23G7 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4104 | |||||||
| 4105 | |||||||||
| 4106 | |||||||||
| 4122 | |||||||||
| Pos_neg_data | 10736 | ||||||||
| 10737 | |||||||||
| 10738 | |||||||||
| Reference (75) | |||||||||
| Picture | WBPicture0000013091 | ||||||||
| Remark | [Ceol C, Horvitz HR] dpl-1 T23G7.1 | ||||||||
| was attached to lin gene class. sdm 01/12 | |||||||||
| Method | Gene |
