WormBase Tree Display for Gene: WBGene00001037

WBGene00001037 SMap: S_parent: Sequence: T05C3
  Identity: Version: 2
    Name: CGC_name: dnj-19 Person_evidence: WBPerson625
      Sequence_name: T05C3.5
      Molecular_name: T05C3.5
        T05C3.5.1
        CE13229
      Other_name: dnj-6 Person_evidence: WBPerson625
        CELE_T05C3.5 Accession_evidence: NDB BX284605
      Public_name: dnj-19
    DB_info: Database: AceView gene 5F982
        WormQTL gene WBGene00001037
        WormFlux gene WBGene00001037
        NDB locus_tag CELE_T05C3.5
        Panther gene CAEEL|WormBase=WBGene00001037|UniProtKB=O16303
          family PTHR43888
        NCBI gene 3565862
        RefSeq protein NM_072051.8
        TrEMBL UniProtAcc O16303
        UniProt_GCRP UniProtAcc O16303
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:22 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 16 Dec 2005 10:14:29 WBPerson1849 Event: Acquires_merge: WBGene00001024
              Name_change: Other_name: dnj-6
      Acquires_merge: WBGene00001024
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: dnj
    Allele (36)
    Strain: WBStrain00036527
      WBStrain00036534
      WBStrain00036688
    RNASeq_FPKM (74)
    GO_annotation (11)
    Ortholog (38)
    Paralog: WBGene00001030 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001028 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00001036 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: This gene encodes a protein containing a DnaJ ('J') domain. Paper_evidence: WBPaper00012768
            WBPaper00012859
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable protein-folding chaperone binding activity. Involved in response to topologically incorrect protein. Predicted to be located in cytosol. Is an ortholog of human DNAJA2 (DnaJ heat shock protein family (Hsp40) member A2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Disease_relevance: C. elegans is an effective model system to study heat-related pathologies like heat stroke; in elegans, the heat-shock transcription factor, after activation, induces the expression of other small heat shock proteins (sHSP); HSP-16.1 has a protective effect against heat-induced necrosis; HSP-16.1 localizes to the golgi and functions together with the PMR-1/PMR1 Ca2+ and Mn2+ transporting ATPase, and NUCB-1/Nucleobindin1, a golgi-located calcium-buffering protein, to maintain calcium homeostasis, under heat stroke; overexpresiion of pmr-1/PMR1 is sufficient to promote survival after heat stroke, bypassing both HSF-1 and HSP-16.1, indicating that PMR-1/PMR1 functions downstream of both these genes; also, the sHSPs, HSP-16.1, HSP-16.41 and DNJ-19 are required for an acquired tolerance to heat stroke. Homo sapiens Paper_evidence: WBPaper00041564
          Curator_confirmed: WBPerson324
          Date_last_updated: 29 May 2013 00:00:00
  Molecular_info: Corresponding_CDS: T05C3.5
    Corresponding_transcript: T05C3.5.1
    Other_sequence (74)
    Associated_feature: WBsf652628
      WBsf981935
      WBsf233683
  Experimental_info: RNAi_result: WBRNAi00035196 Inferred_automatically: RNAi_primary
      WBRNAi00063654 Inferred_automatically: RNAi_primary
      WBRNAi00018224 Inferred_automatically: RNAi_primary
      WBRNAi00052501 Inferred_automatically: RNAi_primary
      WBRNAi00011119 Inferred_automatically: RNAi_primary
      WBRNAi00106334 Inferred_automatically: RNAi_primary
      WBRNAi00041102 Inferred_automatically: RNAi_primary
      WBRNAi00081619 Inferred_automatically: RNAi_primary
      WBRNAi00076648 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1021572
      Expr1030649
      Expr1156125
      Expr2010993
      Expr2029231
    Drives_construct: WBCnstr00037126
      WBCnstr00039336
    Construct_product: WBCnstr00037126
      WBCnstr00039336
    Antibody: WBAntibody00002787
      WBAntibody00002797
    Microarray_results (28)
    Expression_cluster (120)
    Interaction (309)
  Map_info: Map: V Position: -1.79099 Error: 0.011606
    Positive: Positive_clone: T05C3 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00006377
    WBPaper00031384
    WBPaper00034765
    WBPaper00038491
    WBPaper00055090
    WBPaper00061655
    WBPaper00064733
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene