WormBase Tree Display for Gene: WBGene00000991
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| WBGene00000991 | SMap | S_parent | Sequence | M03A8 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | dhs-28 | Person_evidence | WBPerson651 | |||||
| Sequence_name | M03A8.1 | ||||||||
| Molecular_name | M03A8.1 | ||||||||
| M03A8.1.1 | |||||||||
| CE04770 | |||||||||
| Other_name | CELE_M03A8.1 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | dhs-28 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:22 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | dhs | ||||||||
| Allele (44) | |||||||||
| Strain | WBStrain00035626 | ||||||||
| WBStrain00040189 | |||||||||
| WBStrain00050737 | |||||||||
| WBStrain00050738 | |||||||||
| WBStrain00050736 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (16) | |||||||||
| Ortholog (37) | |||||||||
| Paralog (38) | |||||||||
| Structured_description | Concise_description | dhs-28 encodes an ortholog of human 17-BETA-HYDROXYSTEROID DEHYDROGENASE 4 (HSD17B4; OMIM:601860, mutated in D-bifunctional protein deficiency), which contains a C-terminal SCP-2 sterol transfer domain; the deletion allele dhs-28(ok450) is superficially wild-type. | Paper_evidence | WBPaper00004424 | |||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable oxidoreductase activity. Involved in several processes, including carbohydrate derivative metabolic process; dauer entry; and positive regulation of developmental process. Located in peroxisome. Expressed in hypodermis. Used to study obesity. Human ortholog(s) of this gene implicated in D-bifunctional protein deficiency; Perrault syndrome; and Stiff-Person syndrome. Is an ortholog of human HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:9970 | Homo sapiens | Paper_evidence | WBPaper00035972 | ||||
| Curator_confirmed | WBPerson38202 | ||||||||
| Date_last_updated | 29 Jun 2018 00:00:00 | ||||||||
| Potential_model | DOID:13366 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5213) | |||||
| DOID:0090031 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5213) | ||||||
| DOID:0050857 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5213) | ||||||
| Models_disease_asserted | WBDOannot00000570 | ||||||||
| WBDOannot00000571 | |||||||||
| Molecular_info | Corresponding_CDS | M03A8.1 | |||||||
| Corresponding_transcript | M03A8.1.1 | ||||||||
| Other_sequence (107) | |||||||||
| Associated_feature | WBsf648263 | ||||||||
| WBsf648264 | |||||||||
| WBsf662918 | |||||||||
| WBsf235872 | |||||||||
| WBsf235873 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00108444 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00008998 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00050847 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00034393 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00025981 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00092604 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr8991 | ||||||||
| Expr1020554 | |||||||||
| Expr1030616 | |||||||||
| Expr1154542 | |||||||||
| Expr2010912 | |||||||||
| Expr2029151 | |||||||||
| Drives_construct | WBCnstr00013659 | ||||||||
| WBCnstr00037154 | |||||||||
| Construct_product | WBCnstr00013659 | ||||||||
| WBCnstr00023002 | |||||||||
| WBCnstr00037154 | |||||||||
| Antibody | WBAntibody00001955 | ||||||||
| WBAntibody00002918 | |||||||||
| Microarray_results (27) | |||||||||
| Expression_cluster (216) | |||||||||
| Interaction (99) | |||||||||
| Map_info | Map | X | Position | -2.40245 | Error | 0.010942 | |||
| Positive | Positive_clone | M03A8 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4258 | |||||||
| 4343 | |||||||||
| 5031 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (31) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
